The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Necrotic Death Pathway in FAS Receptor Signaling
Open accessAbstract
A caspase 8–deficient subline (JB6) of human Jurkat cells can be killed by the oligomerization of Fas-associated protein with death domain (FADD). This cell death process is not accompanied by caspase activation, but by necrotic morphological changes. Here, we show that the death effector domain of FADD is responsible for the FADD-mediated necrotic pathway. This process was accompanied by a loss of mitochondrial transmembrane potential (ΔΨm), but not by the release of cytochrome c from mitochondria. Pyrrolidine dithiocarbamate, a metal chelator and antioxidant, efficiently inhibited the FADD-induced reduction of ΔΨm and necrotic cell death. When human Jurkat, or its transformants, expressing mouse Fas were treated with Fas ligand or anti–mouse Fas antibodies, the cells died, showing characteristics of apoptosis. A broad caspase inhibitor (z-VAD–fmk) blocked the apoptotic morphological changes and the release of cytochrome c. However, the cells still died, and this cell death process was accompanied by a strong reduction in ΔΨm, as well as necrotic morphological changes. The presence of z-VAD–fmk and pyrrolidine dithiocarbamate together blocked cell death, suggesting that both apoptotic and necrotic pathways can be activated through the Fas death receptor.
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Cites
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Regulated necrosis: the expanding network of non-apoptotic cell death pathways
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Mechanisms of Cell Protection by Heme Oxygenase-1
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Metadata
- Authors
- Matsumura, H., Shimizu, Y., Ohsawa, Y., Kawahara, A., Uchiyama, Y., & Nagata, S.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2000-12-11
- Volume
- 151
- Issue
- 6
- Pages
- 1247-1256
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2056641170
- Cited by
- 240
- References
- 10
- FWCI
- 6.31
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Matsumura, H., Shimizu, Y., Ohsawa, Y., Kawahara, A., Uchiyama, Y., & Nagata, S. (2000). Necrotic Death Pathway in FAS Receptor Signaling. The Journal of Cell Biology. https://doi.org/10.1083/jcb.151.6.1247
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