Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor
Kato, Masaki, Patel, Millan S., Levasseur, Regis, Lobov, Ivan, Chang, Benny H.-J., Glass, Donald A., Hartmann, Christine, Li, Lan, Hwang, Tae-Ho, Brayton, Cory F., Lang, Richard A., Karsenty, Gerard, Chan, Lawrence·2002·The Journal of Cell Biology
Cited by (999)
Items 801–900 of 999
- Turning down the system: counter‐regulatory mechanisms in bone and adaptive immunityMarc Nathan Wein, Dallas C. Jones, Laurie H. Glimcher · 2005 · Immunological Reviews
- Association of a single nucleotide polymorphism in the secreted frizzled‐related protein 4 (sFRP4) gene with bone mineral densityMasayo Fujita, Tomohiko Urano, Masataka Shiraki, Mikio Momoeda, Osamu Tsutsumi, Takayuki Hosoi, Hajime Orimo, Yasuyoshi Ouchi, Satoshi Inoue · 2004 · Geriatrics and gerontology international/Geriatrics & gerontology international
- A Gene(s) for All-trans-Retinoic Acid-Induced Forelimb Defects Mapped and Confirmed to Murine Chromosome 11Grace S. Lee, Rita M. Cantor, Arin Abnoosian, Euisun Park, Mitsuko Lynn Yamamoto, David N. Hovland, Michael D. Collins · 2005 · Genetics
- Assessment of MYC Gene and WNT Pathway Alterations in Early-Onset Colorectal Cancer Among Hispanic/Latino Patients Using Integrated Multi-Omics ApproachesFrancisco Carranza, Brigette Waldrup, Yuxin Jin, Yonatan Amzaleg, Mackenzie D. Postel, David Wesley Craig, John David Carpten, Bodour Salhia, D Hernandez, N Gutierrez et al. · 2024 · medRxiv
- Targeting the Wnt/β-catenin signal pathway for the treatment of gastrointestinal cancer: Potential for advancementXizhi Jin, Sijie Wang, Lihua Luo, Fangjie Yan, Qiaojun He · 2024 · Biochemical Pharmacology
- Interactions Among Osteoblasts, Osteoclasts, and Other Cells in BoneT. John Martin, Natalie A. Sims, Julian M.W. Quinn · 2010 · Elsevier eBooks
- Role and Function of Wnts in the Regulation of Myogenesis: When Wnt Meets MyostatinYann Fédon, Anne Bonnieu, Stphanie Gay, Barbara Vernus, Francis Bacou, Henri Bernardi · 2012 · InTech eBooks
- Anaplerotic Accumulation of Tricarboxylic Acid Cycle Intermediates as Well as Changes in Other Key Metabolites During Heterotopic OssificationEleanor L. Davis, Elizabeth A. Salisbury, Elizabeth A. Olmsted‐Davis, Alan R. Davis · 2015 · Journal of Cellular Biochemistry
- The Roles of Wnt Signaling in Early Mouse Development and Embryonic Stem CellsCaroline R. KempMarijke, Luc Leyns · 2007
- Low density lipoprotein receptor-related protein 5 gene polymorphisms and osteoporosis in Thai menopausal womenAnong Kitjaroentham, Hathairad Hananantachai, Benjaluck Phonrat, Sangchai Preutthipan, Rungsunn Tungtrongchitr · 2016 · Journal of Negative Results in BioMedicine
- OsteoblastenAlexander Hofmann, Stefan G. Mattyasovszky, C. Brüning, Ulrike Ritz, Isabella Maria Mehling, Andrea Meurer, Pol Maria Rommens · 2009 · Der Orthopäde
- NFAT Signaling and Bone HomeostasisS Chen · 2013 · Journal of Hematology & Thromboembolic Diseases
- Identification of novel genes associated with fracture healing in osteoporosis induced by Krm2 overexpression or Lrp5 deficiencyFeng Gao, Feng Xu, Dankai Wu, Jieping Cheng, Peng Xia · 2017 · Molecular Medicine Reports
- Progeroid syndrome as a model for impaired bone formation in senile osteoporosisAkinori Hishiya, Ken Watanabe · 2004 · Journal of Bone and Mineral Metabolism
- Balancing WNT signalling in early forebrain development: The role of LRP4 as a modulator of LRP6 functionShuang Geng, Fabian Paul, Izabela Kowalczyk, Sandra Raimundo, Anje Sporbert, Tamrat M. Mamo, Annette Hammes · 2023 · Frontiers in Cell and Developmental Biology
- LRP5 Signaling in Osteosarcomagenesis: a Cautionary Tale of Translation from Cell Lines to TumorsLogan Horne, Frank R. Avilucea, Huifeng Jin, Jared James Barrott, Kyllie Smith-Fry, Yanliang Wang, Bang H. Hoang, Kevin B. Jones · 2016 · Translational Oncology
- Novel Homozygous LRP5 Mutations in Mexican Patients with Osteoporosis-Pseudoglioma SyndromeMirena C. Astiazarán, María Cervantes-Sodi, Erick Rebolledo-Enríquez, Oscar Francisco Chacon-Camacho, Vanessa Villegas-Ruíz, Juan Carlos Zenteno · 2017 · Genetic Testing and Molecular Biomarkers
- Effect of kirenol on the interaction between the WNT/β-Catenin and RUNX2/TCF/LEF1 pathways in fracture healing in vivoİbrahim Karaman, Ali Eray Günay, Mükerrem Betül Yerer, Eren Demirpolat, Serap Doğan, Arzu Hanım YAY, İbrahim Halil Kafadar · 2020 · Acta Orthopaedica et Traumatologica Turcica
- Identification of Rare LRP5 Variants in a Cohort of Males with Impaired Bone MassMaria Santa Rocca, Giovanni Minervini, Andrea Di Nisio, Maurizio Merico, Maria Bueno Marinas, Luca De Toni, Kalliopi Pilichou, Andrea Garolla, Carlo Foresta, Alberto Ferlin · 2021 · International Journal of Molecular Sciences
- In Adult Skeletal Muscles, the Co-Receptors of Canonical Wnt Signaling, Lrp5 and Lrp6, Determine the Distribution and Size of Fiber Types, and Structure and Function of Neuromuscular JunctionsLea Gessler, Christopher Kurtek, Mira Merholz, Yongzhi Jian, Said Hashemolhosseini · 2022 · Cells
- Association of lipid parameters and insulin resistance with bone health in South Korean adolescentsSooGyeong Park, Ga-Eun Nam, D. Jung, S. Yoon, K. Han, Young-Gyu Park, Jun-Seok Choi, Jangwook Lee, J. Sang, Yeo-Joon Yoon et al. · 2016 · Osteoporosis International
- Wnt Proteins in Mineralized Tissue Development and HomeostasisKevin A. Tompkins · 2011 · Connective Tissue Research
- Relevance of Wnt signaling for osteoanabolic therapyTimur Alexander Yorgan, Thorsten Schinke · 2014 · Molecular and Cellular Therapies
- Genetic Collagen Diseases: Influence of Collagen Mutations on Structure and Mechanical BehaviorRobert Daniel Blank, Adele L. Boskey · 2008 · Springer eBooks
- Influence of an LRP5 cytoplasmic SNP on Wnt signaling and osteoblastic differentiationJiasheng Guo, Lyndon F. Cooper · 2006 · Bone
- The Role of Wnt Signaling in Bone and Mineral MetabolismPeter V.N. Bodine, John A. Robinson, Ramesh A. Bhat, Julia Billiard, Frederick J. Bex, Barry S. Komm · 2006 · Clinical Reviews in Bone and Mineral Metabolism
- Morphologic and Morphometric Analysis and Growth Rings Identification of Otoliths: Sagitta, Asteriscus and Lapillus of Yellowfin Tuna Thunnus albacares (Bonaterre, 1788) (Pisces: Scombridae) in the Eastern PacificHeriberto Santana-He, Elaine Espino-Bar, Manuel Gallardo-C, Arturo García-Boa · 2008 · International Journal of Zoological Research
- “A Friend Among Strangers” or the Ambiguous Roles of Runx2Kseniia Azarkina, Ekaterina Gromova, Anna Malashicheva · 2024 · Biomolecules
- High bone density and bone healthKarin Sedó Sarkis, Marcelo Antônio Amaro Pinheiro, Vera Lúcia Szejnfeld, Lígia Araújo Martini · 2012 · Endocrinología y Nutrición (English Edition)
- Deletion of Dicer blocks osteogenic differentiation via the inhibition of Wnt signallingHongyan Wu, Rui Bi, Ting Sun, Fei Xie · 2019 · Molecular Medicine Reports
- HU-671, a Novel Oleoyl Serine Derivative, Exhibits Enhanced Efficacy in Reversing Ovariectomy-Induced Osteoporosis and Bone Marrow AdipositySaja Baraghithy, Reem Smoum, Malka Attar-Namdar, Raphael Mechoulam, Itai Bab, Joseph Tam · 2019 · Molecules
- FBW7 couples structural integrity with functional output of primary ciliaEleni Petsouki, Vasileios Gerakopoulos, Nicholas Szeto, Wenhan Chang, Mary Beth Humphrey, Leonidas Tsiokas · 2021 · Communications Biology
- Transcriptional Control of Osteoblast Differentiation and FunctionThorsten Schinke, Gérard Karsenty · 2008 · Elsevier eBooks
- Future Developments in Osteoporosis TherapyK.W. Ng · 2009 · Endocrine Metabolic & Immune Disorders - Drug Targets
- No mutations in the serotonin related TPH1 and HTR1B genes in patients with monogenic sclerosing bone disordersEveline Boudin, Karen Jennes, Fenna de Freitas, David H. Tegay, Geert R. Mortier, Wim Van Hul · 2013 · Bone
- Treatment and management of osteoporosis–pseudoglioma syndromeRégis Levasseur · 2008 · Expert Review of Endocrinology & Metabolism
- Osteoclast GenerationNaoyuki Takahashi, Nobuyuki Udagawa, Yasuhiro Kobayashi, Masamichi Takami, T. John Martin, Tatsuo Suda · 2008 · Elsevier eBooks
- Osteoporosis, Inflammation and AgeingLia Ginaldi, Lucia Paola Mengoli, Massimo De Martinis · 2009 · Springer eBooks
- Clinical Significance of 1-year Treatment with Raloxifene on Bone and Lipid Metabolism in Japanese Postmenopausal Women with OsteoporosisTakafumi Majima, Yasato Komatsu, Akira Shimatsu, Noriko Satoh, Atsushi Fukao, Kiyoshi NINOMIYA, Tadashi Matsumura, Kazuwa Nakao · 2007 · Endocrine Journal
- Genetic Determinants of Bone Mass and Osteoporotic FractureStuart H. Ralston · 2008 · Elsevier eBooks
- Peak Bone Mass and Its RegulationJean‐Philippe Bonjour, Thierry Chevalley, Serge Ferrari, René Rizzoli · 2003 · Elsevier eBooks
- LRP5 promotes adipose progenitor cell fitness and adipocyte insulin sensitivityNellie Y. Loh, Senthil Kandaswamy Vasan, Daniel B. Rosoff, Emile Roberts, Andrea D. van Dam, Manu Verma, Daniel Phillips, Agata Wesolowska‐Andersen, Matt J. Neville, Raymond Noordam et al. · 2025 · Communications Medicine
- The ultimate microbial composition for correcting Th17/Treg cell imbalance and lipid metabolism disorders in osteoporosisFangyu An, Xueru Jia, Yangyang Shi, Xiaolong Xiao, Fan Yang, Jianrong Su, Peng Xia, Guangqin Geng, Chunlu Yan · 2024 · International Immunopharmacology
- Inactivation of Wnt-LRP5 signaling suppresses the proliferation and migration of ovarian cancer cellsJing Hong, Zeyu Xie, Zhihua Yang, Fangyao Yang, Hai Liao, Shuquan Rao, Xinhe Huang · 2021 · Translational Cancer Research
- Research Progress on the Mechanism of the SFRP-Mediated Wnt Signalling Pathway Involved in Bone Metabolism in OsteoporosisFangyu An, Jiayi Song, Weirong Chang, Jie Zhang, Peng Gao, Yujie Wang, Zhipan Xiao, Chunlu Yan · 2024 · Molecular Biotechnology
- Screening for Activators of the Wingless Type/Frizzled Pathway by Automated Fluorescent MicroscopyKristen M. Borchert, Rachelle J. Sells Galvin, Laura V. Hale, O. Joseph Trask, Debra R. Nickischer, Keith A. Houck · 2006 · Methods in enzymology on CD-ROM/Methods in enzymology
- Serum levels of sclerostin, Dickkopf-1, and secreted frizzled-related protein-4 are not changed in individuals with high bone mass causing mutations in LRP5Christine A. Simpson, Dinah Foer, G. S. Lee, Jessica Dauz Bihuniak, Ben‐hua Sun, Rebecca Sullivan, Joseph L. Belsky, Karl Leonard Insogna · 2014 · Osteoporosis International
- Genetic Analysis of the Relationship between Bone Mineral Density and Low-Density Lipoprotein Receptor-Related Protein 5 Gene PolymorphismsJiayong Yi, Yu Cai, Zhenjun Yao, Jianping Lin · 2013 · PLoS ONE
- The Association of LRP5 Gene Polymorphisms with Ankylosing Spondylitis in a Chinese Han PopulationJianmin Liu, Xiaoyan Zhou, ZHENXING SHAN, Jiguo Yang, Qingrui Yang, Yazhou Cui, Jinxiang Han · 2011 · The Journal of Rheumatology
- Expression of Signaling Components in Embryonic Eyelid EpitheliumQinghang Meng, Chang Jin, Yinglei Chen, Jing Chen, Mario Medvedovic, Ying Xia · 2014 · PLoS ONE
- Animal Models of Bone Diseases-ALixin Kan · 2013 · Elsevier eBooks
- Molecular Regulation of Osteoblast DifferentiationPrasanna L Bukka, Marc D. McKee, Andrew C. Karaplis · 2004 · Springer eBooks
- Genetic contributors to osteoporosis in pregnancy and lactation associated osteoporosis (PLO)Lauren Lynch, Patrick R. Shea, Natalie Vena, Wendy K. Chung, Elizabeth J. Shane, Mafo Kamanda‐Kosseh, Jordan Barry, Dany B. El-Najjar, Sanchita Agarwal, Ananya V. Kondapalli et al. · 2025 · Bone
- Claudins in Retinal Disease: Beyond Barrier Integrity to Signaling and TherapyMohamed S. Selim, S. Priya Narayanan, Payaningal R. Somanath · 2026 · Cells
- Wnt7b expressed by hypertrophic chondrocytes is a stimulatory factor for endochondral ossification that is regulated by Smad4 activitySho Tsukamoto, Mai Kuratani, Shinya Tanaka, Eijiro Jimi, Hiromi Oda, Takenobu Katagiri · 2023 · Development
- Osteoporosis-pseudoglioma syndrome in four new patients: identification of two novel LRP5 variants and insights on patients’ management using bisphosphonates therapyMohamed S. Abdel‐Hamid, Rasha Moheb Elhossini, Ghada Ahmed Otaify, Sherif F. Abdel‐Ghafar, Mona Aglan · 2022 · Osteoporosis International
- Structure and function of the retina of low-density lipoprotein receptor-related protein 5 (Lrp5)-deficient ratsJohn L. Ubels, Cheng‐mao Lin, David A. Antonetti, Mónica Díaz-Coránguez, Cassandra R. Diegel, Bart O. Williams · 2022 · Experimental Eye Research
- Lrp5 p. Val667Met Variant Compromises Bone Mineral Density and Matrix Properties in OsteoporosisStéphanie Fabre, Morgane Bourmaud, Guillaume Mabilleau, Ruben Goulet, Aude Couturier, Alexandre Dentel, Serge A. Picaud, Thomas Funck‐Brentano, Corinne Collet, Martine Esther Cohen-Solal · 2023 · JBMR Plus
- β‐Catenin transcriptional activity is minimal in canine osteosarcoma and its targeted inhibition results in minimal changes to cell line behaviourCaroline M. Piskun, Timothy J. Stein · 2013 · Veterinary and Comparative Oncology
- Sialoglycoprotein from Gadous morhua eggs improve high bone turnover activity via down-regulating BMP-2/Smads and Wnt/β-catenin signal pathwaysKai Wang, Lihua Han, Na Wang, Yiming Wang, Jingfeng Wang · 2018 · Food Science and Biotechnology
- Osteoporosis, Inflammation, and AgingLia Ginaldi, Lucia Paola Mengoli, Maria Maddalena Sirufo, Massimo De Martinis · 2019 · Springer eBooks
- WNT Signaling in Skeletal Homeostasis and DiseasesFrancesca Gori, Roland Baron · 2013 · Elsevier eBooks
- Potential blindness in children of patients with hereditary bone diseaseV. Kheir, Francis L. Munier, Bérengère Aubry‐Rozier, Daniel F. Schorderet · 2015 · Osteoporosis International
- The Wnt‐signaling pathways in mammalian patterning and morphogenesisJianbo Wang, Leah Etheridge, Anthony J. Wynshaw-Boris · 2007 · Advances in developmental biology
- Characterization of the function of type XIII collagen in mice; specific roles during cardiovascular development and posnatally in bone modelingRiikka Ylönen · 2005
- Bevacizumab and sunitinib mediate osteogenic and pro-inflammatory molecular changes in primary human alveolar osteoblasts in vitroElena Hofmann, Benedikt Eggers, Nils Heim, Franz‐Josef Kramer, Marjan Nokhbehsaim, Werner Götz · 2022 · Odontology
- Intracellular Signal Transduction Pathways and Transcription Factors for OsteogenesisGun‐Il Im · 2008 · Journal of Rheumatic Diseases
- Insulin-like Growth Factors and the IGF Binding ProteinsClifford james Rosen, Tianhua Niu · 2008 · Elsevier eBooks
- Dyslipidemia and bone metabolism. A common bond of the osteoporosis and the atherosclerosisJosé L. Hernández, Olmos Martínez, González Macías J · 2011
- Alterations in β‑catenin/E‑cadherin complex formation during the mechanotransduction of Saos‑2 osteoblastic cellsFeifei Li, Bo Zhang, Jihong Cui, Fu‐Lin Chen, Yin Ding, Xue Feng · 2018 · Molecular Medicine Reports
- Expression, purification and functional characterization of Wnt signaling co-receptors LRP5 and LRP6Damien Fleury, Béatrice Vayssière, Robert Touitou, Corinne Gillard, Hélène Lebhar, Georges Rawadi, Patrick Mollat · 2009 · Protein Expression and Purification
- Osteoblast BiologyJane B. Lian, Gary S. Stein · 2008 · Elsevier eBooks
- The Cells of BoneJane B. Lian, Gary S. Stein · 2006 · Elsevier eBooks
- New agents for the treatment of osteoporosisThomas John Martin, Kong Wah Ng · 2007 · BoneKEy-Osteovision
- Non-association Between Polymorphisms of the Frizzled Receptor Genes and Bone Mineral Density in Postmenopausal Korean WomenJung Gu Kim, Hoon Kim, Byung Chul Jee, Chang Suk Suh, Young Min Choi, Shin Yong Moon · 2009 · Journal of Korean Medical Science
- Extremely low-frequency electromagnetic fields facilitate both osteoblast and osteoclast activity through Wnt/β-catenin signaling in the zebrafish scaleJingjing Kobayashi-Sun, Isao Kobayashi, Makoto Kashima, Jun Hirayama, Makiko Kakikawa, Sotoshi Yamada, Nobuo Suzuki · 2024 · Frontiers in Cell and Developmental Biology
- TRUE Gene Silencing : Unique Gene Silencing by the tRNA Maturase tRNase ZL under the Direction of Small-guide RNAAiko Nakashima, Masayuki Nashimoto, Masato Tamura · 2007 · Journal of Oral Biosciences
- Normal hematopoiesis and lack of β-catenin activation in osteoblasts of patients and mice harboring Lrp5 gain-of-function mutationsMarta Galán-Díez, Adiba Isa, Marco Ponzetti, Morten Frost Nielsen, Moustapha S Kassem, Stavroula Kousteni · 2015 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
- Ocular NeovascularizationPeter A. Campochiaro · 2008 · Springer eBooks
- WNT signaling in skeletal homeostasis and diseasesFrancesca Gori, Roland Baron · 2020 · Elsevier eBooks
- LDL receptor-related protein 5 rs648438 polymorphism is associated with the risk of skeletal fluorosisMeichen Zhang, Haili Xu, Qun Lou, Fanshuo Yin, Ning Guo, Liaowei Wu, Wei Huang, Yi Ji, Yang Liu, Qiao Li et al. · 2023 · International Journal of Environmental Health Research
- Wnt Signaling and BoneMark L. Johnson · 2008 · Elsevier eBooks
- Osteogenesis from Pluripotent Stem Cells: Neural Crest or Mesodermal Origin?Kevin C., Nicole I. zur Nieden · 2011 · InTech eBooks
- Association of a single nucleotide polymorphism in Wnt10bgene with bone mineral densityTakahiko Usui, Tomohiko Urano, Masataka Shiraki, Yasuyoshi Ouchi, Satoshi Inoue · 2007 · Geriatrics and gerontology international/Geriatrics & gerontology international
- LRP5 : le gène muté dans le syndrome d'ostéoporose avec pseudogliome et le phénotype de masse osseuse élevéeRégis Levasseur, Didier Lacombe, Marie Christine de Vernejoul · 2005 · Revue du Rhumatisme
- 17-β-estradiol up-regulates apolipoprotein genes expression during osteoblast differentiation in vitroYuyan Gui, Nan Chu, Xuemin Qiu, Wei Tang, Hans-Jürgen Gober, Da‐Jin Li, Ling Wang · 2016 · BioScience Trends
- Biology, Physiology, and Morphology of BoneJanet E. Rubin, Clinton T. Rubin · 2009 · Elsevier eBooks
- Development of the SkeletonSylvain Provot, Ernestina Schipani, Joy Y. Wu, Henry M. Kronenberg · 2008 · Elsevier eBooks
- Clinical Implementation of Bone Regeneration and MaintenanceMike Barbeck, Nahum Rosenberg, Željka Perić Kačarević, Jung, Ole, Rider, Patrick · 2019 · IntechOpen eBooks
- Basic Principles of Bone Cell BiologyThomas John Martin, Kong Wah Ng, Natalie A. Sims · 2012 · Elsevier eBooks
- Remodelage osseuxMartine Esther Cohen-Solal, Marie Christine de Vernejoul · 2003 · Therapies
- New functions for old hormones: Bone as an endocrine organKong Wah Ng, Thomas John Martin · 2009 · Molecular and Cellular Endocrinology
- Advances in the management of myeloma bone diseaseC M Shipman, Babatunde O. Oyajobi, Gregory R. Mundy · 2005 · Expert Opinion on Pharmacotherapy
- Wnt signaling, LRP5 and gut serotonin: Have we been targeting the right pathway for the wrong reasons?Roland Baron · 2009 · IBMS BoneKEy
- Skeletal cell YAP and TAZ redundantly promote bone development by regulation of collagen I expression and organizationChristopher D. Kegelman, Devon E. Mason, James H. Dawahare, Genevieve D. Vigil, Scott S. Howard, Teresita Bellido, Alexander G. Robling, Joel D. Boerckel · 2017 · bioRxiv (Cold Spring Harbor Laboratory)
- Differential bone metabolism and protein expression in mice fed a high-fat diet versus Daurian ground squirrels following natural pre-hibernation fatteningXuli Gao, Shenyang Shen, Qiaohua Niu, Weilan Miao, Yuting Han, Ziwei Hao, Ning An, Yingyu Yang, Yu Zhang, Han Zhang et al. · 2022 · Journal of Zhejiang University SCIENCE B
- Unique Splicing of Lrp5 in the Brain: A New Player in Neurodevelopment and Brain MaturationAureli Luquero, Noelia Pimentel, Gemma Vilahur, Lina Badimón, María Borrell-Pagés · 2024 · International Journal of Molecular Sciences
- Palm Tocotrienol Activates the Wnt3a/β-Catenin Signaling Pathway, Protecting MC3T3-E1 Osteoblasts from Cellular Damage Caused by Dexamethasone and Promoting Bone FormationNorfarahin Abdullah Sani, Nur Aqilah Kamaruddin, Ima Nirwana Soelaiman, Kok-Lun Pang, Kok‐Yong Chin, Elvy Suhana Mohd Ramli · 2025 · Biomedicines
- Wnt signaling in bonePeter V.N. Bodine · 2007 · BoneKEy-Osteovision
- Altered bone microarchitecture and gene expression profile due to calcium deficiency in a mouse model of myelomaHélène Libouban, Daniel Chappard · 2017 · Micron