Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor

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3. Myeloma cells suppress bone formation by secreting a soluble Wnt inhibitor, sFRP-2
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4. Dkk2 has a role in terminal osteoblast differentiation and mineralized matrix formation
   Xiaofeng Li, Peng Liu, Wenzhong Liu, Peter F. Maye, Jianghong Zhang, Yazhou Zhang, Marja M. Hurley, Caiying Guo, Adele L. Boskey, Le Sun et al. · 2005 · Nature Genetics
5. Wnt signalling in osteoblasts regulates expression of the receptor activator of NFκB ligand and inhibits osteoclastogenesis in vitro
   Gary J. Spencer, Jennifer C. Utting, S. Leah Etheridge, Timothy R. Arnett, Paul G. Genever · 2006 · Journal of Cell Science
6. Msx2 Promotes Osteogenesis and Suppresses Adipogenic Differentiation of Multipotent Mesenchymal Progenitors
   Su‐Li Cheng, Jian-Su Shao, Nichole Charlton-Kachigian, Arleen P. Loewy, Dwight A. Towler · 2003 · Journal of Biological Chemistry
7. Runx2: A master organizer of gene transcription in developing and maturing osteoblasts
   Tania M. Schroeder, Eric D. Jensen, Jennifer J. Westendorf · 2005 · Birth Defects Research Part C Embryo Today Reviews
8. Gone with the Wnts: β-Catenin, T-Cell Factor, Forkhead Box O, and Oxidative Stress in Age-Dependent Diseases of Bone, Lipid, and Glucose Metabolism
   Stavros C. Manolagas, Maria Almeida · 2007 · Molecular Endocrinology
9. BMP-2 and Insulin-like Growth Factor-I Mediate Osterix (Osx) Expression in Human Mesenchymal Stem Cells via the MAPK and Protein Kinase D Signaling Pathways
   Ayse B. Celil, Phil G. Campbell · 2005 · Journal of Biological Chemistry
10. A Wnt canon orchestrating osteoblastogenesis
    Christine Hartmann · 2006 · Trends in Cell Biology
11. Noncanonical Wnt Signaling through G Protein-Linked PKCδ Activation Promotes Bone Formation
    Xiaolin Tu, Kyu Sang Joeng, Keiko Nakayama, Keiko Nakayama, Jayaraj Rajagopal, Thomas J. Carroll, Andrew P. McMahon, Fanxin Long · 2007 · Developmental Cell
12. Wnt signalling in osteoporosis: mechanisms and novel therapeutic approaches
    ERNESTO M. CANALIS · 2013 · Nature Reviews Endocrinology
13. Molecular, Endocrine, and Genetic Mechanisms of Arterial Calcification
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14. Wnt signaling and cellular metabolism in osteoblasts
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15. The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice
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16. Wnt signaling and osteoblastogenesis
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17. Osteoblasts: novel roles in orchestration of skeletal architecture
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18. Effects of Wnt Signaling on Proliferation and Differentiation of Human Mesenchymal Stem Cells
    Jan de Boer, Hong Jun Wang, Clemens van Blitterswijk · 2004 · Tissue Engineering
19. Wnt/β-Catenin Signaling Is a Component of Osteoblastic Bone Cell Early Responses to Load-bearing and Requires Estrogen Receptor α
    Victoria J. Armstrong, Mariusz Muzylak, Andrew Sunters, Gul Zaman, Leanne Saxon, J. S. Price, Lance E. Lanyon · 2007 · Journal of Biological Chemistry
20. Circulating Sclerostin Levels and Bone Turnover in Type 1 and Type 2 Diabetes
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21. Glucocorticoid suppresses the canonical Wnt signal in cultured human osteoblasts
    Keizo Ohnaka, Mizuho Tanabe, Hisaya Kawate, Hajime Nawata, Ryoichi Takayanagi · 2005 · Biochemical and Biophysical Research Communications
22. Atorvastatin Inhibits Hypercholesterolemia-Induced Calcification in the Aortic Valves via the Lrp5 Receptor Pathway
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23. WNT as a Driver and Dependency in Cancer
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24. New Insights into the Mechanism of Wnt Signaling Pathway Activation
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25. The WNT system: background and its role in bone
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26. Reduced Affinity to and Inhibition by DKK1 Form a Common Mechanism by Which High Bone Mass-Associated Missense Mutations in LRP5 Affect Canonical Wnt Signaling
    Minrong Ai, Sheri L. Holmen, Wim Van Hul, Bart O. Williams, Matthew L. Warman · 2005 · Molecular and Cellular Biology
27. Inhibiting Dickkopf-1 (Dkk1) Removes Suppression of Bone Formation and Prevents the Development of Osteolytic Bone Disease in Multiple Myeloma
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28. Wnt and the Wnt signaling pathway in bone development and disease
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29. Polymorphisms in the Low-Density Lipoprotein Receptor–Related Protein 5 (LRP5) Gene Are Associated with Variation in Vertebral Bone Mass, Vertebral Bone Size, and Stature in Whites
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31. Regulation of Bone Remodeling by Parathyroid Hormone
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32. Wnt signaling inhibits osteogenic differentiation of human mesenchymal stem cells
    Jan de Boer, Ramakrishnaiah Siddappa, Claudia Gaspar, Aart A. van Apeldoorn, Riccardo Fodde, Clemens van Blitterswijk · 2004 · Bone
33. The role of magnesium ions in bone regeneration involves the canonical Wnt signaling pathway
    Hung, Chu-Chih, Chaya, Amy, Liu, Kai, Verdelis, Konstantinos, Sfeir, Charles · 2019 · Acta Biomaterialia
34. A Model for mechanotransduction in bone cells: The load‐bearing mechanosomes
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35. Wnt signaling as a therapeutic target for bone diseases
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36. Involvement of WNT/β-catenin Signaling in the Treatment of Osteoporosis
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37. Coordinated Activation of Notch, Wnt, and Transforming Growth Factor-β Signaling Pathways in Bone Morphogenic Protein 2-induced Osteogenesis
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38. Sox2 induction by FGF and FGFR2 activating mutations inhibits Wnt signaling and osteoblast differentiation
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39. Physiological role of collagen XVIII and endostatin
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40. BMP‐9‐induced osteogenic differentiation of mesenchymal progenitors requires functional canonical Wnt/β‐catenin signalling
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41. Regulation of Human Skeletal Stem Cells Differentiation by Dlk1/Pref-1
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42. Noncanonical Wnt-4 Signaling Enhances Bone Regeneration of Mesenchymal Stem Cells in Craniofacial Defects through Activation of p38 MAPK
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43. Understanding the pathology and mechanisms of type I diabetic bone loss
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44. Cooperation Between TGF-β and Wnt Pathways During Chondrocyte and Adipocyte Differentiation of Human Marrow Stromal Cells
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45. Canonical and noncanonical Wnt signaling: Multilayered mediators, signaling mechanisms and major signaling crosstalk
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46. Effects of parathyroid hormone on Wnt signaling pathway in bone
    Nalini H. Kulkarni, David L. Halladay, Rebecca R. Miles, Linda C. Gilbert, Charles A. Frolik, Rachelle J. Sells Galvin, Thomas John Martin, Matthew T. Gillespie, Jude E. Onyia · 2005 · Journal of Cellular Biochemistry
47. Bone Regeneration Is Regulated by Wnt Signaling
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48. LRP5 Mutations Linked to High Bone Mass Diseases Cause Reduced LRP5 Binding and Inhibition by SOST
    Mikhail V. Semënov, Xi He · 2006 · Journal of Biological Chemistry
49. ?-Catenin and BMP-2 synergize to promote osteoblast differentiation and new bone formation
    Gabriel Mbalaviele, Sharmin Sheikh, Joseph P. Stains, Valerie S Salazar, Su‐Li Cheng, Di Chen, Roberto Civitelli · 2004 · Journal of Cellular Biochemistry
50. Wnt Signaling: A Key Regulator of Bone Mass
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51. Inhibition of Wnt signaling by Wise (Sostdc1) and negative feedback from Shh controls tooth number and patterning
    Youngwook Ahn, Brian W. Sanderson, Ophir D. Klein, Robb K. Krumlauf · 2010 · Development
52. The two faces of serotonin in bone biology
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53. Wnt signaling in neuroprotection and stem cell differentiation
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54. LRP5 and Wnt Signaling: A Union Made for Bone
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55. Wnt Signaling in vascular eye diseases
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56. Autosomal Recessive Familial Exudative Vitreoretinopathy Is Associated with Mutations in LRP5
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57. LRP6 overexpression defines a class of breast cancer subtype and is a target for therapy
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58. The WNT signalling pathway and diabetes mellitus
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59. Where Wnts Went: The Exploding Field of Lrp5 and Lrp6 Signaling in Bone
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60. Heterozygous Mutations in the LDL Receptor-Related Protein 5 ( LRP5 ) Gene Are Associated With Primary Osteoporosis in Children
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61. Structural Basis of Wnt Signaling Inhibition by Dickkopf Binding to LRP5/6
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62. In Vivo Analysis of Wnt Signaling in Bone
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63. Inhibiting Dickkopf-1 (Dkk1) Removes Suppression of Bone Formation and Prevents the Development of Osteolytic Bone Disease in Multiple Myeloma
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64. The Fos‐related antigen Fra‐1 is an activator of bone matrix formation
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65. Glucocorticoid enhances the expression of dickkopf-1 in human osteoblasts: novel mechanism of glucocorticoid-induced osteoporosis
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66. High levels of β-catenin signaling reduce osteogenic differentiation of stem cells in inflammatory microenvironments through inhibition of the noncanonical Wnt pathway
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68. Wnt Signaling in Bone Development and Disease: Making Stronger Bone with Wnts
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69. Connective-tissue growth factor modulates WNT signalling and interacts with the WNT receptor complex
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70. T Lymphocytes Amplify the Anabolic Activity of Parathyroid Hormone through Wnt10b Signaling
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71. Serotonergic Mechanisms Regulating the GI Tract: Experimental Evidence and Therapeutic Relevance
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72. Lymphoid Enhancer Factor-1 and -Catenin Inhibit Runx2-dependent Transcriptional Activation of the Osteocalcin Promoter
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81. Knockout mouse models to study Wnt signal transduction
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