The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Intraflagellar transport (IFT) cargo
Open accessAbstract
Intraflagellar transport (IFT) is the bidirectional movement of multisubunit protein particles along axonemal microtubules and is required for assembly and maintenance of eukaryotic flagella and cilia. One posited role of IFT is to transport flagellar precursors to the flagellar tip for assembly. Here, we examine radial spokes, axonemal subunits consisting of 22 polypeptides, as potential cargo for IFT. Radial spokes were found to be partially assembled in the cell body, before being transported to the flagellar tip by anterograde IFT. Fully assembled radial spokes, detached from axonemal microtubules during flagellar breakdown or turnover, are removed from flagella by retrograde IFT. Interactions between IFT particles, motors, radial spokes, and other axonemal proteins were verified by coimmunoprecipitation of these proteins from the soluble fraction of Chlamydomonas flagella. These studies indicate that one of the main roles of IFT in flagellar assembly and maintenance is to transport axonemal proteins in and out of the flagellum.
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Pazour, G. J., Dickert, B. L., Vucica, Y., Seeley, E. S., Rosenbaum, J. L., Witman, G. B., & Cole, D. G. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.151.3.709 · Cited by 1,147
Self-citationA motility in the eukaryotic flagellum unrelated to flagellar beating.
Kozminski, K. G., Johnson, K. A., Forscher, P., & Rosenbaum, J. L. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.12.5519 · Cited by 1,007
Self-citationCole, D. G., Diener, D. R., Himelblau, A. L., Beech, P. L., Fuster, J. C., & Rosenbaum, J. L. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.141.4.993 · Cited by 898
Self-citationMicrotubules containing acetylated alpha-tubulin in mammalian cells in culture.
Piperno, G., LeDizet, M., & Chang, X. J. (1987) · The Journal of cell biology · doi:10.1083/jcb.104.2.289 · Cited by 873
Kozminski, K. G., Beech, P. L., & Rosenbaum, J. L. (1995) · The Journal of cell biology · doi:10.1083/jcb.131.6.1517 · Cited by 586
Self-citationThe DHC1b (DHC2) Isoform of Cytoplasmic Dynein Is Required for Flagellar Assembly
Pazour, G. J., Dickert, B. L., & Witman, G. B. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.144.3.473 · Cited by 471
Cytoplasmic Dynein Heavy Chain 1b Is Required for Flagellar Assembly in Chlamydomonas
Porter, M. E., Bower, R., Knott, J. A., Byrd, P., & Dentler, W. (1999) · Molecular Biology of the Cell · doi:10.1091/mbc.10.3.693 · Cited by 333
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Fliegauf, M., Benzing, T., & Omran, H. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2278 · Cited by 1,257
Overview of Structure and Function of Mammalian Cilia
Satir, P., & Christensen, S. T. (2007) · Annual Review of Physiology · doi:10.1146/annurev.physiol.69.040705.141236 · Cited by 1,142
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Gupta, G. D., Coyaud, É., Gonçalves, J., Mojarad, B. A., Liu, Y., Wu, Q., Gheiratmand, L., Comartin, D., Tkach, J. M., Cheung, S. W. T., et al. (2015) · Cell · doi:10.1016/j.cell.2015.10.065 · Cited by 538
Chapter Two Intraflagellar Transport (IFT)
Pedersen, L. B., & Rosenbaum, J. L. (2008) · Current Topics in Developmental Biology · doi:10.1016/s0070-2153(08)00802-8 · Cited by 521
Self-citationMukhopadhyay, S., Wen, X., Chih, B., Nelson, C. D., Lane, W. S., Scales, S. J., & Jackson, P. K. (2010) · Genes & Development · doi:10.1101/gad.1966210 · Cited by 435
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Taschner, M., & Lorentzen, E. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a028092 · Cited by 349
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Bhogaraju, S., Cajanek, L., Fort, C., Blisnick, T., Weber, K., Taschner, M., Mizuno, N., Lamla, S., Bastin, P., Nigg, E. A., et al. (2013) · Science · doi:10.1126/science.1240985 · Cited by 317
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Garcia-Gonzalo, F. R., & Reiter, J. F. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a028134 · Cited by 290
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Iomini, C., Tejada, K., Mo, W., Vaananen, H., & Piperno, G. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200312133 · Cited by 241
Stages of ciliogenesis and regulation of ciliary length
Avasthi, P., & Marshall, W. F. (2012) · Differentiation · doi:10.1016/j.diff.2011.11.015 · Cited by 234
Qin, H., Burnette, D. T., Bae, Y.-K., Forscher, P., Barr, M. M., & Rosenbaum, J. L. (2005) · Current Biology · doi:10.1016/j.cub.2005.08.047 · Cited by 206
Self-citationThe roles of evolutionarily conserved functional modules in cilia-related trafficking
Sung, C.-H., & Leroux, M. R. (2013) · Nature Cell Biology · doi:10.1038/ncb2888 · Cited by 186
Qin, J., Lin, Y., Norman, R. X., Ko, H. W., & Eggenschwiler, J. T. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1011410108 · Cited by 176
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Badgandi, H. B., Hwang, S.-H., Shimada, I. S., Loriot, E., & Mukhopadhyay, S. (2017) · Journal of Cell Biology · doi:10.1083/jcb.201607095 · Cited by 182
Pedersen, L. B., Miller, M. S., Geimer, S., Leitch, J. M., Rosenbaum, J. L., & Cole, D. G. (2005) · Current Biology · doi:10.1016/j.cub.2005.01.037 · Cited by 164
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Nachury, M. V. (2014) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2013.0465 · Cited by 150
Lechtreck, K. F., Brown, J. M., Sampaio, J. L., Craft, J. M., Shevchenko, A., Evans, J. E., & Witman, G. B. (2013) · Journal of Cell Biology · doi:10.1083/jcb.201207139 · Cited by 140
Behal, R. H., Miller, M. S., Qin, H., Lucker, B. F., Jones, A., & Cole, D. G. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.287102 · Cited by 119
Self-citationThe molecular structure of IFT-A and IFT-B in anterograde intraflagellar transport trains
Lacey, S. E., Foster, H. E., & Pigino, G. (2023) · Nature Structural & Molecular Biology · doi:10.1038/s41594-022-00905-5 · Cited by 119
Intraflagellar transport complex structure and cargo interactions
Bhogaraju, S., Engel, B. D., & Lorentzen, E. (2013) · Cilia · doi:10.1186/2046-2530-2-10 · Cited by 111
Yanagisawa, H.-A., Mathis, G., Oda, T., Hirono, M., Richey, E. A., Ishikawa, H., Marshall, W. F., Kikkawa, M., & Qin, H. (2014) · Molecular Biology of the Cell · doi:10.1091/mbc.e13-08-0464 · Cited by 89
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Metadata
- Authors
- Qin, H., Diener, D. R., Geimer, S., Cole, D. G., & Rosenbaum, J. L.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2004-01-12
- Volume
- 164
- Issue
- 2
- Pages
- 255-266
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2116079099
- Cited by
- 342
- References
- 7
- FWCI
- 12.12
- Type
- journal article
- Language
- en
- Open access
- green
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