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A role for the actin cytoskeleton in cell death and aging in yeast
Open accessAbstract
Several determinants of aging, including metabolic capacity and genetic stability, are recognized in both yeast and humans. However, many aspects of the pathways leading to cell death remain to be elucidated. Here we report a role for the actin cytoskeleton both in cell death and in promoting longevity. We have analyzed yeast strains expressing mutants with either increased or decreased actin dynamics. We show that decreased actin dynamics causes depolarization of the mitochondrial membrane and an increase in reactive oxygen species (ROS) production, resulting in cell death. Important, however, is the demonstration that increasing actin dynamics, either by a specific actin allele or by deletion of a gene encoding the actin-bundling protein Scp1p, can increase lifespan by over 65%. Increased longevity appears to be due to these cells producing lower than wild-type levels of ROS. Homology between Scp1p and mammalian SM22/transgelin, which itself has been isolated in senescence screens, suggests a conserved mechanism linking aging to actin stability.
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Lin, S.-J., Defossez, P.-A., & Guarente, L. (2000) · Science · doi:10.1126/science.289.5487.2126 · Cited by 1,775
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Metadata
- Authors
- Gourlay, C. W., Carpp, L. N., Timpson, P., Winder, S. J., & Ayscough, K. R.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2004-03-15
- Volume
- 164
- Issue
- 6
- Pages
- 803-809
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2031726991
- Cited by
- 290
- References
- 1
- FWCI
- 5.92
- Type
- journal article
- Language
- en
- Open access
- green
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- Gourlay, C. W., Carpp, L. N., Timpson, P., Winder, S. J., & Ayscough, K. R. (2004). A role for the actin cytoskeleton in cell death and aging in yeast. The Journal of Cell Biology. https://doi.org/10.1083/jcb.200310148
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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