The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
An AIF orthologue regulates apoptosis in yeast
Open accessAbstract
Apoptosis-inducing factor (AIF), a key regulator of cell death, is essential for normal mammalian development and participates in pathological apoptosis. The proapoptotic nature of AIF and its mode of action are controversial. Here, we show that the yeast AIF homologue Ynr074cp controls yeast apoptosis. Similar to mammalian AIF, Ynr074cp is located in mitochondria and translocates to the nucleus of yeast cells in response to apoptotic stimuli. Purified Ynr074cp degrades yeast nuclei and plasmid DNA. YNR074C disruption rescues yeast cells from oxygen stress and delays age-induced apoptosis. Conversely, overexpression of Ynr074cp strongly stimulates apoptotic cell death induced by hydrogen peroxide and this effect is attenuated by disruption of cyclophilin A or the yeast caspase YCA1. We conclude that Ynr074cp is a cell death effector in yeast and rename it AIF-1 (Aif1p, gene AIF1).
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Molecular characterization of mitochondrial apoptosis-inducing factor
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Epitope tagging of yeast genes using a PCR-based strategy: more tags and improved practical routines
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Oxygen Stress: A Regulator of Apoptosis in Yeast
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Self-citationA Caspase-Related Protease Regulates Apoptosis in Yeast
Madeo, F., Herker, E., Maldener, C., Wissing, S., Lächelt, S., Herlan, M., Fehr, M., Lauber, K., Sigrist, S. J., Wesselborg, S., et al. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00501-4 · Cited by 872
Self-citationA Yeast Mutant Showing Diagnostic Markers of Early and Late Apoptosis
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Self-citationIMPORT OF PROTEINS INTO MITOCHONDRIA
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Chronological aging leads to apoptosis in yeast
Herker, E., Jungwirth, H., Lehmann, K. A., Maldener, C., Fröhlich, K.-U., Wissing, S., Büttner, S., Fehr, M., Sigrist, S., & Madeo, F. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200310014 · Cited by 548
Self-citationSaccharomyces cerevisiae commits to a programmed cell death process in response to acetic acid
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Eisenberg, T., Knauer, H., Schauer, A., Büttner, S., Ruckenstuhl, C., Carmona-Gutierrez, D., Ring, J., Schroeder, S., Magnes, C., Antonacci, L., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb1975 · Cited by 1,680
AIF deficiency compromises oxidative phosphorylation
Vahsen, N., Candé, C., Brière, J., Bénit, P., Joza, N., Larochette, N., Mastroberardino, P. G., Pequignot, M. O., Casares, N., Lazar, V., et al. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600461 · Cited by 623
Self-citationApoptosis in yeast: triggers, pathways, subroutines
Carmona-Gutierrez, D., Eisenberg, T., Büttner, S., Meisinger, C., Kroemer, G., & Madeo, F. (2010) · Cell Death & Differentiation · doi:10.1038/cdd.2009.219 · Cited by 484
Self-citationProgrammed cell death in aging
Tower, J. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.04.002 · Cited by 426
Pospisilik, J. A., Knauf, C., Joza, N., Benit, P., Orthofer, M., Cani, P. D., Ebersberger, I., Nakashima, T., Sarao, R., Neely, G., et al. (2007) · Cell · doi:10.1016/j.cell.2007.08.047 · Cited by 404
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Metadata
- Authors
- Wissing, S., Ludovico, P., Herker, E., Büttner, S., Engelhardt, S. M., Decker, T., Link, A., Proksch, A., Rodrigues, F., Corte-Real, M., Fröhlich, K.-U., Manns, J., Candé, C., Sigrist, S. J., Kroemer, G., & Madeo, F.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2004-09-20
- Volume
- 166
- Issue
- 7
- Pages
- 969-974
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2098657730
- Cited by
- 396
- References
- 30
- FWCI
- 9.40
- Type
- journal article
- Language
- en
- Open access
- green
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- Wissing, S., Ludovico, P., Herker, E., Büttner, S., Engelhardt, S. M., Decker, T., Link, A., Proksch, A., Rodrigues, F., Corte-Real, M., Fröhlich, K.-U., Manns, J., Candé, C., Sigrist, S. J., Kroemer, G., & Madeo, F. (2004). An AIF orthologue regulates apoptosis in yeast. The Journal of Cell Biology. https://doi.org/10.1083/jcb.200404138
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