Early aging–associated phenotypes in Bub3/Rae1 haploinsufficient mice

Genetic instabilities in human cancers

Lengauer, C., Kinzler, K. W., & Vogelstein, B. (1998) · Nature · doi:10.1038/25292 · Cited by 4,168 · cited 1× · see citing works

Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors

Campisi, J. (2005) · Cell · doi:10.1016/j.cell.2005.02.003 · Cited by 2,359 · cited 1× · see citing works

The p53 pathway: positive and negative feedback loops

Harris, S. L., & Levine, A. J. (2005) · Oncogene · doi:10.1038/sj.onc.1208615 · Cited by 1,967 · see citing works

p53 mutant mice that display early ageing-associated phenotypes

Tyner, S. D., Venkatachalam, S., Choi, J., Jones, S., Ghebranious, N., Igelmann, H., Lu, X., Soron, G., Cooper, B., Brayton, C., et al. (2002) · Nature · doi:10.1038/415045a · Cited by 1,459 · cited 1× · see citing works

On the road to cancer: aneuploidy and the mitotic checkpoint

Kops, G. J. P. L., Weaver, B. A. A., & Cleveland, D. W. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1714 · Cited by 1,188 · see citing works

The signals and pathways activating cellular senescence

Ben-Porath, I., & Weinberg, R. A. (2005) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2004.10.013 · Cited by 1,046 · see citing works

DNA Repair, Genome Stability, and Aging

Lombard, D. B., Chua, K. F., Mostoslavsky, R., Franco, S., Gostissa, M., & Alt, F. W. (2005) · Cell · doi:10.1016/j.cell.2005.01.028 · Cited by 944 · see citing works

The Anaphase-Promoting Complex

Peters, J. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00540-3 · Cited by 909 · see citing works

Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2

Sudakin, V., Chan, G. K. T., & Yen, T. J. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.200102093 · Cited by 907 · see citing works

BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice

Baker, D. J., Jeganathan, K. B., Cameron, J. D., Thompson, M., Juneja, S., Kopecka, A., Kumar, R., Jenkins, R. B., de Groen, P. C., Roche, P., et al. (2004) · Nature Genetics · doi:10.1038/ng1382 · Cited by 731 · see citing works

Aneuploidy and cancer

Rajagopalan, H., & Christoph Lengauer, C. (2004) · Nature · doi:10.1038/nature03099 · Cited by 730 · see citing works

MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells

Michel, L. S., Liberal, V., Chatterjee, A., Kirchwegger, R., Pasche, B., Gerald, W. L., Dobles, M., Sorger, P. K., Murty, V. V. V. S., & Benezra, R. (2001) · Nature · doi:10.1038/35053094 · Cited by 725 · see citing works

Stuck in Division or Passing through

Rieder, C. L., & Maiato, H. (2004) · Developmental Cell · doi:10.1016/j.devcel.2004.09.002 · Cited by 648 · see citing works

Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B

Hanks, S., Coleman, K., Reid, S., Plaja, A., Firth, H., Fitzpatrick, D., Kidd, A., Méhes, K., Nash, R., Robin, N. H., et al. (2004) · Nature Genetics · doi:10.1038/ng1449 · Cited by 627 · see citing works

THE STRUCTURE AND FUNCTION OF SMC AND KLEISIN COMPLEXES

Nasmyth, K., & Haering, C. H. (2005) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.74.082803.133219 · Cited by 612 · see citing works

The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiationPreprint

Fang, G., Yu, H., & Kirschner, M. W. (1998) · Genes & Development · doi:10.1101/gad.12.12.1871 · Cited by 597 · see citing works

Merotelic Kinetochore Orientation Is a Major Mechanism of Aneuploidy in Mitotic Mammalian Tissue Cells

Cimini, D., Howell, B., Maddox, P., Khodjakov, A., Degrassi, F., & Salmon, E. D. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.153.3.517 · Cited by 568 · see citing works

Aging and Genome Maintenance: Lessons from the Mouse?

Hasty, P., Campisi, J., Hoeijmakers, J., van Steeg, H., & Vijg, J. (2003) · Science · doi:10.1126/science.1079161 · Cited by 553 · see citing works

A role for the Adenomatous Polyposis Coli protein in chromosome segregation

Kaplan, K. B., Burds, A. A., Swedlow, J. R., Bekir, S., Sorger, P. K., & Näthke, I. S. (2001) · Nature Cell Biology · doi:10.1038/35070123 · Cited by 545 · see citing works

Premature Aging in Mice Deficient in DNA Repair and Transcription

de Boer, J., Andressoo, J. O., de Wit, J., Huijmans, J., Beems, R. B., van Steeg, H., Weeda, G., van der Horst, G. T. J., van Leeuwen, W., Themmen, A. P. N., et al. (2002) · Science · doi:10.1126/science.1070174 · Cited by 545 · see citing works

Timing and checkpoints in the regulation of mitotic progression.

Meraldi, P., Draviam, V. M., & Sorger, P. (2004) · Developmental Cell · doi:10.1016/j.devcel.2004.06.006 · Cited by 528 · see citing works

Chromosome Missegregation and Apoptosis in Mice Lacking the Mitotic Checkpoint Protein Mad2

Dobles, M., Liberal, V., Scott, M. L., Benezra, R., & Sorger, P. K. (2000) · Cell · doi:10.1016/s0092-8674(00)80875-2 · Cited by 525 · see citing works

Decoding the links between mitosis, cancer, and chemotherapy: The mitotic checkpoint, adaptation, and cell death

Weaver, B. A. A., & Cleveland, D. W. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.06.011 · Cited by 523 · see citing works

Chromosome segregation and cancer: cutting through the mystery

Jallepalli, P. V., & Christoph Lengauer, C. (2001) · Nature reviews. Cancer · doi:10.1038/35101065 · Cited by 464 · see citing works

Lethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint

Kops, G. J. P. L., Foltz, D. R., & Cleveland, D. W. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401142101 · Cited by 438 · see citing works

Mad2-Independent Inhibition of APCCdc20 by the Mitotic Checkpoint Protein BubR1

Tang, Z., Bharadwaj, R., Li, B., & Yu, H. (2001) · Developmental Cell · doi:10.1016/s1534-5807(01)00019-3 · Cited by 411 · see citing works

Regulation of APC-Cdc20 by the spindle checkpoint.

Yu, H.-T. (2002) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(02)00382-4 · Cited by 379 · see citing works

CREB Binding Protein Interacts with Nucleoporin-Specific FG Repeats That Activate Transcription and Mediate NUP98-HOXA9 Oncogenicity

Kasper, L. H., Brindle, P. K., Schnabel, C., Pritchard, C., Cleary, M., & van Deursen, J. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.1.764 · Cited by 357 · see citing works

Rae1 is an essential mitotic checkpoint regulator that cooperates with Bub3 to prevent chromosome missegregation

Babu, J. R., Jeganathan, K. B., Baker, D. J., Wu, X., Kang, N., & van Deursen, J. M. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200211048 · Cited by 342 · see citing works

Increased activity of p53 in senescing fibroblasts

Atadja, P., Wong, H., Garkavtsev, I., Veillette, C., & Riabowol, K. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.18.8348 · Cited by 308 · see citing works

Precision and Accuracy of Dual‐Energy X‐ray Absorptiometry for Determining in Vivo Body Composition of Mice

Nagy, T. R., & Clair, A. (2000) · Obesity Research · doi:10.1038/oby.2000.47 · Cited by 293 · see citing works

Slippage of Mitotic Arrest and Enhanced Tumor Development in Mice with BubR1 Haploinsufficiency

Dai, W. H., Wang, Q., Liu, T., Swamy, M. V., Fang, Y., Xie, S., Mahmood, R., Yang, Y., Xu, M., & Rao, C. V. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3119 · Cited by 291 · see citing works

Waiting for Anaphase

Shah, J. V., & Cleveland, D. W. (2000) · Cell · doi:10.1016/s0092-8674(00)00202-6 · Cited by 276 · see citing works

RAE1 Is a Shuttling mRNA Export Factor That Binds to a GLEBS-like NUP98 Motif at the Nuclear Pore Complex through Multiple Domains

Pritchard, C. E. J., Fornerod, M. W. J., Kasper, L. H., & van Deursen, J. M. A. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.145.2.237 · Cited by 246 · see citing works

Bub3 gene disruption in mice reveals essential mitotic spindle checkpoint function during early embryogenesisPreprint

Kalitsis, P., Earle, E., Fowler, K. J., & Choo, K. H. A. (2000) · Genes & Development · doi:10.1101/gad.827500 · Cited by 241 · see citing works

The anorexia of aging

MacIntosh, C. G., Morley, J. E., & Chapman, I. M. (2000) · Nutrition · doi:10.1016/s0899-9007(00)00405-6 · Cited by 224 · see citing works

Regulation of Human Separase by Securin Binding and Autocleavage

Waizenegger, I. C., Giménez-Abián, J. F., Wernic, D., & Peters, J.-M. (2002) · Current Biology · doi:10.1016/s0960-9822(02)01073-4 · Cited by 222 · see citing works

Targeting and function in mRNA export of nuclear pore complex protein Nup153.

Bastos, R. N., Lin, A., Enarson, M., & Burke, B. E. (1996) · The Journal of Cell Biology · doi:10.1083/jcb.134.5.1141 · Cited by 195 · see citing works

Complete loss of the tumor suppressor MAD2 causes premature cyclin B degradation and mitotic failure in human somatic cells

Michel, L., Diaz-Rodriguez, E., Narayan, G., Hernando, E., Murty, V. V. V. S., & Benezra, R. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0306069101 · Cited by 188 · see citing works

The Rae1–Nup98 complex prevents aneuploidy by inhibiting securin degradation

Jeganathan, K. B., Malureanu, L. A., & van Deursen, J. M. (2005) · Nature · doi:10.1038/nature04221 · Cited by 184 · see citing works

BUBR1 deficiency results in abnormal megakaryopoiesis

Wang, Q. (2003) · Blood · doi:10.1182/blood-2003-06-2158 · Cited by 183 · see citing works

Dual roles of human BubR1, a mitotic checkpoint kinase, in the monitoring of chromosomal instability

Shin, H.-J., Baek, K., Jeon, A.-H., Park, M.-T., Lee, S., Kang, C.-M., Lee, H., Yoo, S.-H., Chung, D.-H., Sung, Y., et al. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00302-7 · Cited by 173 · see citing works

Chromosome segregation and genomic stability

Draviam, V. M., Xie, S. Z.-J., & Sorger, P. K. (2004) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2004.02.007 · Cited by 168 · see citing works

A Mutation in the Schizosaccharomyces pombe rae1 Gene Causes Defects in Poly(A)+ RNA Export and in the Cytoskeleton

Brown, J. A., Bharathi, A., Ghosh, A., Whalen, W., Fitzgerald, E., & Dhar, R. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.13.7411 · Cited by 153 · see citing works

Disruption of the FG nucleoporin NUP98 causes selective changes in nuclear pore complex stoichiometry and function

Wu, X., Kasper, L. H., Mantcheva, R. T., Mantchev, G. T., Springett, M. J., & van Deursen, J. M. A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051631598 · Cited by 144 · see citing works

Leber hereditary optic neuropathy: Does heteroplasmy influence the inheritance and expression of the G11778A mitochondrial DNA mutation?

Chinnery, P. F., Andrews, R. M., Turnbull, D. M., & Howell, N. (2001) · American Journal of Medical Genetics · doi:10.1002/1096-8628(20010122)98:3 · Cited by 143 · see citing works

Generating chromosome instability through the simultaneous deletion of Mad2 and p53

Burds, A. A., Lutum, A. S., & Sorger, P. K. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505053102 · Cited by 109 · see citing works

ATP-Sensitive K+ Channel Knockout Compromises the Metabolic Benefit of Exercise Training, Resulting in Cardiac Deficits

Kane, G. C., Behfar, A., Yamada, S., Pérez-Terzic, C. M., O’Cochlain, F., Reyes, S., Dzeja, P. P., Miki, T., Seino, S., & Terzic, A. (2004) · Diabetes · doi:10.2337/diabetes.53.suppl_3.s169 · Cited by 99 · see citing works

mRNA binding protein mrnp 41 localizes to both nucleus and cytoplasm

Kraemer, D. M., & Blobel, G. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.17.9119 · Cited by 89 · see citing works

Processing, localization, and requirement of human separase for normal anaphase progression

Chestukhin, A., Pfeffer, C. P., Milligan, S. C., DeCaprio, J. A., & Pellman, D. S. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0730733100 · Cited by 88 · see citing works

The mitotic checkpoint in cancer and aging: what have mice taught us?

Baker, D. J., Chen, J., & van Deursen, J. M. A. (2005) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2005.09.011 · Cited by 87 · see citing works

Cancer-prone syndrome of mosaic variegated aneuploidy and total premature chromatid separation: report of five infants.

Kajii, T., Ikeuchi, T., Yang, Z.-Q., Nakamura, Y., Tsuji, Y., Yokomori, K., Kawamura, M., Fukuda, S., Horita, S., & Asamoto, A. (2001) · American journal of medical genetics · doi:10.1002/ajmg.1580 · Cited by 84 · see citing works

Increased chromosome instability but not cancer predisposition in haploinsufficient Bub3 mice

Kalitsis, P., Fowler, K. J., Griffiths, B., Earle, E., Chow, C. W., Jamsen, K. M., & Choo, K. H. A. (2005) · Genes Chromosomes and Cancer · doi:10.1002/gcc.20215 · Cited by 76 · see citing works

Transgenic overexpression of human DMPK accumulates into hypertrophic cardiomyopathy, myotonic myopathy and hypotension traits of myotonic dystrophy

O'Cochlain, D. F., Pérez-Terzic, C. M., Reyes, S., Kane, G. C., Behfar, A., Hodgson, D. M., Strommen, J. A., Liu, X., van den Broek, W. J. A. A., Wansink, D. G., et al. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh266 · Cited by 63 · see citing works

Mitotic checkpoint function in the formation of gross chromosomal rearrangements in Saccharomyces cerevisiae

Myung, K., Smith, S. N., & Kolodner, R. D. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407010101 · Cited by 51 · see citing works

WD repeat‐containing mitotic checkpoint proteins act as transcriptional repressors during interphase

Yoon, Y., Baek, K.-H., Jeong, S., Shin, H.-J., Ha, G.-H., Jeon, A.-H., Hwang, S.-G., Chun, J.-S., & Lee, C.-W. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.07.089 · Cited by 51 · see citing works

Crystal Structure of the Spindle Assembly Checkpoint Protein Bub3

Larsen, N., & Harrison, S. C. (2004) · Journal of Molecular Biology · doi:10.1016/j.jmb.2004.09.094 · Cited by 40 · see citing works

CAML Is a p56Lck-Interacting Protein that Is Required for Thymocyte Development

Tran, D. D., Edgar, C. E., Heckman, K. L., Sutor, S. L., Huntoon, C. J., van Deursen, J., McKean, D. L., & Bram, R. J. (2005) · Immunity · doi:10.1016/j.immuni.2005.06.006 · Cited by 36 · see citing works

Fat tissue, aging, and cellular senescence

Tchkonia, T., Morbeck, D. E., Von Zglinicki, T., Van Deursen, J., Lustgarten, J., Scrable, H., Khosla, S., Jensen, M. D., & Kirkland, J. L. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00608.x · Cited by 1,094 · see citing works

The common biology of cancer and ageing

Finkel, T., Serrano, M., & Blasco, M. A. (2007) · Nature · doi:10.1038/nature05985 · Cited by 988 · see citing works

Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis

Holland, A. J., & Cleveland, D. W. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2718 · Cited by 859 · see citing works

Aneuploidy Acts Both Oncogenically and as a Tumor Suppressor

Weaver, B. A. A., Silk, A. D., Montagna, C., Verdier-Pinard, P., & Cleveland, D. W. (2007) · Cancer Cell · doi:10.1016/j.ccr.2006.12.003 · Cited by 729 · see citing works

Does aneuploidy cause cancer?

Weaver, B. A. A., & Cleveland, D. W. (2006) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2006.10.002 · Cited by 560 · see citing works

Chromatid cohesion defects may underlie chromosome instability in human colorectal cancers

Barber, T. D., McManus, K. J., Yuen, K. W. Y., Reis, M. M., Parmigiani, G., Shen, D., Barrett, I. J., Nouhi, Y., Spencer, F. A., Markowitz, S. D., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0712384105 · Cited by 432 · see citing works

Mitotic chromosomal instability and cancer: mouse modelling of the human disease

Schvartzman, J. M., Sotillo, R., & Benezra, R. (2010) · Nature reviews. Cancer · doi:10.1038/nrc2781 · Cited by 411 · see citing works

Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency

Baker, D. J., Perez-Terzic, C., Jin, F., Pitel, K. S., Niederländer, N. J., Jeganathan, K., Yamada, S., Reyes, S., Rowe, L., Hiddinga, H. J., et al. (2008) · Nature Cell Biology · doi:10.1038/ncb1744 · Cited by 408 · see citing works

Defining ‘chromosomal instability’

Geigl, J. B., Obenauf, A. C., Schwarzbraun, T., & Speicher, M. R. (2008) · Trends in Genetics · doi:10.1016/j.tig.2007.11.006 · Cited by 344 · see citing works

Losing balance: the origin and impact of aneuploidy in cancer

Holland, A. J., & Cleveland, D. W. (2012) · EMBO Reports · doi:10.1038/embor.2012.55 · Cited by 288 · see citing works

The impact of mitotic errors on cell proliferation and tumorigenesisPreprint

Levine, M. S., & Holland, A. J. (2018) · Genes & Development · doi:10.1101/gad.314351.118 · Cited by 268 · see citing works

Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan

Baker, D. J., Dawlaty, M. M., Wijshake, T., Jeganathan, K. B., Malureanu, L. A., van Ree, J. H., Crespo‐Diaz, R. J., Reyes, S., Seaburg, L., Shapiro, V. S., et al. (2012) · Nature Cell Biology · doi:10.1038/ncb2643 · Cited by 272 · see citing works

The ATM–p53 pathway suppresses aneuploidy-induced tumorigenesis

Li, M., Fang, X., Baker, D. J., Guo, L., Gao, X., Wei, Z., Han, S., van Deursen, J. M., & Zhang, P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005960107 · Cited by 257 · see citing works

Chromosome missegregation rate predicts whether aneuploidy will promote or suppress tumors

Silk, A. D., Zasadil, L. M., Holland, A., Vitre, B., Cleveland, D., & Weaver, B. A. (2013) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1317042110 · Cited by 256 · see citing works

Single-cell sequencing reveals karyotype heterogeneity in murine and human malignancies

Bakker, B., Taudt, A., Belderbos, M. E., Porubskỳ, D., Spierings, D. C. J., de Jong, T. V., Halsema, N., Kazemier, H. G., Hoekstra-Wakker, K., Bradley, A., et al. (2016) · Genome biology · doi:10.1186/s13059-016-0971-7 · Cited by 248 · see citing works

Aneuploidy and chromosomal instability in cancer: a jackpot to chaos

Giam, M., & Rancati, G. I. (2015) · Cell Division · doi:10.1186/s13008-015-0009-7 · Cited by 246 · see citing works

Obesity and aging: Molecular mechanisms and therapeutic approaches

Santos, A. L., & Sinha, S. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101268 · Cited by 240 · see citing works

Senescent cells: SASPected drivers of age-related pathologies

Ovadya, Y., & Krizhanovsky, V. (2014) · Biogerontology · doi:10.1007/s10522-014-9529-9 · Cited by 232 · see citing works

Bub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis

Jeganathan, K. B., Malureanu, L. A., Baker, D., Abraham, S., & van Deursen, J. (2007) · Journal of Cell Biology · doi:10.1083/jcb.200706015 · Cited by 238 · see citing works

Overexpression of the E2 ubiquitin–conjugating enzyme UbcH10 causes chromosome missegregation and tumor formation

van Ree, J. H., Jeganathan, K. B., Malureanu, L. A., & van Deursen, J. M. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.200906147 · Cited by 216 · see citing works

The diverse consequences of aneuploidy

Chunduri, N. K., & Štorchová, Z. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0243-8 · Cited by 207 · see citing works

Spindle formation, chromosome segregation and the spindle checkpoint in mammalian oocytes and susceptibility to meiotic error

Vogt, E.-J., Kirsch‐Volders, M., Parry, J. M., & Eichenlaub-Ritter, U. (2007) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2007.10.015 · Cited by 201 · see citing works

Aneuploidy: Instigator and Inhibitor of Tumorigenesis

Weaver, B. A. A., & Cleveland, D. W. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-2266 · Cited by 195 · see citing works

Aneuploidy and chromosomal instability: a vicious cycle driving cellular evolution and cancer genome chaos

Potapova, T., Zhu, J., & Li, R. (2013) · Cancer and Metastasis Reviews · doi:10.1007/s10555-013-9436-6 · Cited by 168 · see citing works

Whole chromosome instability and cancer: a complex relationship

Ricke, R. M., van Ree, J. H., & van Deursen, J. M. (2008) · Trends in Genetics · doi:10.1016/j.tig.2008.07.002 · Cited by 159 · see citing works

Oxidative stress activates a specific p53 transcriptional response that regulates cellular senescence and aging

Gambino, V., de Michele, G., Venezia, O., Migliaccio, P., Dall’Olio, V., Bernard, L., Minardi, S. P., Fazia, M. A. D., Bartoli, D., Servillo, G., et al. (2013) · Aging Cell · doi:10.1111/acel.12060 · Cited by 152 · see citing works

Bub1 Maintains Centromeric Cohesion by Activation of the Spindle Checkpoint

Perera, D., Tilston, V., Hopwood, J. A., Barchi, M., Boot-Handford, R., & Taylor, S. S. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.08.008 · Cited by 140 · see citing works

The role of adipose tissue senescence in obesity- and ageing-related metabolic disorders

Liu, Z., Wu, K. K.-L., Jiang, X. X., Xu, A., & Cheng, K. K. Y. (2020) · Clinical Science · doi:10.1042/cs20190966 · Cited by 139 · see citing works

Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in mice

Stout, M. B., Tchkonia, T., Pirtskhalava, T., Palmer, A. K., List, E. O., Berryman, D. E., Lubbers, E. R., Escande, C., Spong, A., Masternak, M. M., et al. (2014) · Aging · doi:10.18632/aging.100681 · Cited by 135 · see citing works

FoxM1 repression during human aging leads to mitotic decline and aneuploidy-driven full senescence

Macedo, J. C., Vaz, S., Bakker, B., Ribeiro, R., Bakker, P. L., Escandell, J. M., Ferreira, M. G., Medema, R., Foijer, F., & Logarinho, E. (2018) · Nature Communications · doi:10.1038/s41467-018-05258-6 · Cited by 131 · see citing works

p21 Both Attenuates and Drives Senescence and Aging in BubR1 Progeroid Mice

Baker, D. J., Weaver, R. L., & van Deursen, J. M. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.03.028 · Cited by 130 · see citing works

Loss of spindle assembly checkpoint–mediated inhibition of Cdc20 promotes tumorigenesis in mice

Li, M., Fang, X., Wei, Z., York, J. P., & Zhang, P. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200904020 · Cited by 129 · see citing works

The cancer biology of whole-chromosome instability

Duijf, P. H. G., & Benezra, R. (2013) · Oncogene · doi:10.1038/onc.2012.616 · Cited by 124 · see citing works

The Impact of Aging on Cardio and Cerebrovascular Diseases

Izzo, C., Carrizzo, A., Alfano, A., Virtuoso, N., Capunzo, M., Calabrese, M., Simone, E. D., Sciarretta, S., Frati, G., Oliveti, M., et al. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19020481 · Cited by 127 · see citing works

Pleiotropic Cellular Functions of PARP1 in Longevity and Aging: Genome Maintenance Meets Inflammation

Mangerich, A., & Bürkle, A. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/321653 · Cited by 121 · see citing works

Epigenome-wide DNA methylation landscape of melanoma progression to brain metastasis reveals aberrations on homeobox D cluster associated with prognosis

Marzese, D. M., Scolyer, R. A., Huynh, J. L., Huang, S. K., Hirose, H., Chong, K. K., Kiyohara, E., Wang, J., Kawas, N. P., Donovan, N. C., et al. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt420 · Cited by 116 · see citing works

Mouse Models to Disentangle the Hallmarks of Human Aging

Folgueras, A. R., Freitas-Rodríguez, S., Velasco, G., & López-Otín, C. (2018) · Circulation Research · doi:10.1161/circresaha.118.312204 · Cited by 113 · see citing works

Aneuploidy in health, disease, and aging

Ricke, R. M., & van Deursen, J. M. (2013) · The Journal of Cell Biology · doi:10.1083/jcb.201301061 · Cited by 111 · see citing works

Enhanced genomic instabilities caused by deregulated microtubule dynamics and chromosome segregation: a perspective from genetic studies in mice

Rao, C. V., Yamada, H. Y., Yao, Y., & Dai, W. H. (2009) · Carcinogenesis · doi:10.1093/carcin/bgp081 · Cited by 110 · see citing works

Spartan deficiency causes genomic instability and progeroid phenotypes

Maskey, R. S., Kim, M. S., Baker, D. J., Childs, B. G., Malureanu, L. A., Jeganathan, K. B., Machida, Y., van Deursen, J. M., & Machida, Y. (2014) · Nature Communications · doi:10.1038/ncomms6744 · Cited by 108 · see citing works

2n or not 2n: Aneuploidy, polyploidy and chromosomal instability in primary and tumor cells

Zasadil, L. M., Britigan, E. M. C., & Weaver, B. A. A. (2013) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2013.02.001 · Cited by 107 · see citing works

Mitotic regulation of the anaphase-promoting complex

Baker, D. J., Dawlaty, M. M., Galardy, P. J., & van Deursen, J. M. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-6443-1 · Cited by 106 · see citing works

CENP-A Reduction Induces a p53-Dependent Cellular Senescence Response To Protect Cells from Executing Defective Mitoses

Maehara, K., Takahashi, K., & Saitoh, S. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.01318-09 · Cited by 104 · see citing works

Chromosome instability induced by Mps1 and p53 mutation generates aggressive lymphomas exhibiting aneuploidy-induced stress

Foijer, F., Xie, S. Z.-J., Simon, J. E., Bakker, P. L., Conte, N., Davis, S. H., Kregel, E., Jonkers, J., Bradley, A., & Sorger, P. K. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1400892111 · Cited by 99 · see citing works

PUMILIO hyperactivity drives premature aging of Norad-deficient mice

Kopp, F. B., YALVAÇ, M. E., Chen, B., Zhang, H., 이성율, Gillett, F. A., Elguindy, M. M., Sivakumar, S., Yu, H., Xie, Y., et al. (2019) · eLife · doi:10.7554/elife.42650 · Cited by 94 · see citing works

Genetic instability: tipping the balance

Janssen, A., & Medema, R. H. (2012) · Oncogene · doi:10.1038/onc.2012.576 · Cited by 97 · see citing works

Up-regulation of the mitotic checkpoint component Mad1 causes chromosomal instability and resistance to microtubule poisons

Ryan, S. D., Britigan, E. M. C., Zasadil, L. M., Witte, K., Audhya, A., Roopra, A., & Weaver, B. A. A. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1201911109 · Cited by 97 · see citing works

When 2+2=5: The origins and fates of aneuploid and tetraploid cells

King, R. W. (2008) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2008.07.007 · Cited by 98 · see citing works

Functional characterization of Anaphase Promoting Complex/Cyclosome (APC/C) E3 ubiquitin ligases in tumorigenesis

Zhang, J., Wan, L., Dai, X., Sun, Y., & Wei, W. (2014) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2014.02.001 · Cited by 94 · see citing works

Spindle checkpoint function and cellular sensitivity to antimitotic drugs

Yamada, H. Y., & Gorbsky, G. J. (2006) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-06-0319 · Cited by 94 · see citing works

Bub1 kinase activity drives error correction and mitotic checkpoint control but not tumor suppression

Ricke, R. M., Jeganathan, K. B., Malureanu, L. A., Harrison, A. M., & van Deursen, J. M. (2012) · The Journal of Cell Biology · doi:10.1083/jcb.201205115 · Cited by 93 · see citing works

The role of aneuploidy in promoting and suppressing tumors

Weaver, B. A. A., & Cleveland, D. W. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200905098 · Cited by 90 · see citing works

The spindle assembly checkpoint: Preventing chromosome mis‐segregation during mitosis and meiosis

Malmanche, N., Maia, A. F., & Sunkel, C. E. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.03.081 · Cited by 87 · see citing works

Mapping of quantitative trait loci controlling lifespan in the short‐lived fish Nothobranchius furzeri – a new vertebrate model for age research

Kirschner, J., Weber, D., Neuschl, C., Franke, A., Böttger, M., Zielke, L. G., Powalsky, E., Groth, M., Shagin, D. A., Petzold, A., et al. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00780.x · Cited by 83 · see citing works

The ageing epigenome: Damaged beyond repair?

Sinclair, D. A., & Oberdoerffer, P. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2009.04.004 · Cited by 83 · see citing works

Modeling complex genetic interactions in a simple eukaryotic genome: actin displays a rich spectrum of complex haploinsufficienciesPreprint

Haarer, B. K., Viggiano, S. C., Hibbs, M. A., Troyanskaya, O. G., & Amberg, D. C. (2006) · Genes & Development · doi:10.1101/gad.1477507 · Cited by 83 · see citing works

Cell divisions and mammalian aging: integrative biology insights from genes that regulate longevity

de Magalhães, J. P., & Faragher, R. (2008) · BioEssays · doi:10.1002/bies.20760 · Cited by 81 · see citing works

Aneuploidy and tumorigenesis

Fang, X., & Zhang, P. (2011) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2011.03.002 · Cited by 79 · see citing works

Preventing aneuploidy: The contribution of mitotic checkpoint proteins

Suijkerbuijk, S. J. E., & Kops, G. J. P. L. (2008) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2008.04.001 · Cited by 74 · see citing works

DNA double-strand breaks: A potential causative factor for mammalian aging?

Li, H., Mitchell, J. R., & Hasty, P. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.02.002 · Cited by 74 · see citing works

Lin9, a Subunit of the Mammalian DREAM Complex, Is Essential for Embryonic Development, for Survival of Adult Mice, and for Tumor Suppression

Reichert, N., Wurster, S., Ulrich, T., Schmitt, K., Hauser, S., Probst, L., Götz, R., Ceteci, F., Moll, R., Rapp, U. R., et al. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.00028-10 · Cited by 68 · see citing works

DNA Damage Response and Spindle Assembly Checkpoint Function throughout the Cell Cycle to Ensure Genomic Integrity

Lawrence, K. S., Chau, T., & Engebrecht, J. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1005150 · Cited by 70 · see citing works

Spindle Assembly Checkpoint Regulates Mitotic Cell Cycle Progression during Preimplantation Embryo Development

Wei, Y., Multi, S., Yang, C., Ma, J., Zhang, Q.-H., Wang, Z.-B., Li, M., Liang, W. P., Ge, Z., Zhang, C.-H., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021557 · Cited by 67 · see citing works

The nuclear envelopathies and human diseases

Chi, Y., Chen, Z.-J., & Jeang, K. (2009) · Journal of Biomedical Science · doi:10.1186/1423-0127-16-96 · Cited by 64 · see citing works

Aneuploidy in Cancer and Aging

Naylor, R. M., & van Deursen, J. M. (2016) · Annual Review of Genetics · doi:10.1146/annurev-genet-120215-035303 · Cited by 63 · see citing works

Overexpression of Ubiquitin Specific Protease 44 (USP44) Induces Chromosomal Instability and Is Frequently Observed in Human T-Cell Leukemia

Zhang, Y., van Deursen, J., & Galardy, P. J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023389 · Cited by 64 · see citing works

CIN and Aneuploidy: Different Concepts, Different Consequences

Schukken, K. M., & Foijer, F. (2017) · BioEssays · doi:10.1002/bies.201700147 · Cited by 61 · see citing works

Cdc20 hypomorphic mice fail to counteract de novo synthesis of cyclin B1 in mitosis

Malureanu, L. A., Jeganathan, K. B., Jin, F., Baker, D. J., van Ree, J. H., Gullon, O., Chen, Z., Henley, J. R., & van Deursen, J. M. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.201003090 · Cited by 58 · see citing works

Reduced Life- and Healthspan in Mice Carrying a Mono-Allelic BubR1 MVA Mutation

Wijshake, T., Malureanu, L. A., Baker, D. J., Jeganathan, K. B., van de Sluis, B., & van Deursen, J. M. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1003138 · Cited by 59 · see citing works

Mad2 and BubR1 modulates tumourigenesis and paclitaxel response in MKN45 gastric cancer cells

Bargiela-Iparraguirre, J., Prado-Marchal, L., Pajuelo‐Lozano, N., Jiménez, B., Perona, R., & Sánchez‐Pérez, I. (2014) · Cell Cycle · doi:10.4161/15384101.2014.962952 · Cited by 59 · see citing works

The yin and yang of the Cdkn2a locus in senescence and aging

Baker, D. J., Jin, F., & van Deursen, J. M. (2008) · Cell Cycle · doi:10.4161/cc.7.18.6687 · Cited by 56 · see citing works

Tetraploidy in cancer and its possible link to aging

Tanaka, K., Goto, H., Nishimura, Y., Kasahara, K., Mizoguchi, A., & Inagaki, M. (2018) · Cancer Science · doi:10.1111/cas.13717 · Cited by 54 · see citing works

Studying chromosome instability in the mouse

Foijer, F., Draviam, V. M., & Sorger, P. K. (2008) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2008.07.004 · Cited by 55 · see citing works

Mechanisms and consequences of aneuploidy and chromosome instability in the aging brain

Andriani, G. A., Vijg, J., & Montagna, C. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.03.007 · Cited by 55 · see citing works

Surveillance mechanism linking Bub1 loss to the p53 pathway

Gjoerup, O. V., Wu, J., Chandler-Militello, D., Williams, G. L., Zhao, J. J., Schaffhausen, B. S., Jat, P., & Roberts, T. M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703164104 · Cited by 54 · see citing works

Hypoxia tolerance, longevity and cancer-resistance in the mole rat Spalax – a liver transcriptomics approach

Schmidt, H., Malik, A., Bicker, A., Poetzsch, G., Avivi, A., Shams, I., & Hankeln, T. (2017) · Scientific Reports · doi:10.1038/s41598-017-13905-z · Cited by 51 · see citing works

Links between DNA Replication, Stem Cells and Cancer

Vassilev, A. P., & Depamphilis, M. (2017) · Genes · doi:10.3390/genes8020045 · Cited by 50 · see citing works

Centromere fission, not telomere erosion, triggers chromosomal instability in human carcinomas

Martínez‐A, C., & van Wely, K. H. M. (2011) · Carcinogenesis · doi:10.1093/carcin/bgr069 · Cited by 46 · see citing works

A machine learning approach to unmask novel gene signatures and prediction of Alzheimer's disease within different brain regions

Sharma, A., & Dey, P. (2021) · Genomics · doi:10.1016/j.ygeno.2021.04.028 · Cited by 46 · see citing works

The role of cellular senescence in aging through the prism of Koch-like criteria

Yanai, H., & Fraifeld, V. E. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2017.10.004 · Cited by 45 · see citing works

Meta‐analysis on blood transcriptomic studies identifies consistently coexpressed protein–protein interaction modules as robust markers of human aging

van den Akker, E. B., Passtoors, W. M., Jansen, R., van Zwet, E. W., Goeman, J. J., Hulsman, M., Emilsson, V., Perola, M., Willemsen, G. A. H. M., Penninx, B. W. J. H., et al. (2013) · Aging Cell · doi:10.1111/acel.12160 · Cited by 44 · see citing works

Heterochromatic genome instability and neurodegeneration sharing similarities with Alzheimer’s disease in old Bmi1+/− mice

el Hajjar, J., Chatoo, W., Hanna, R., Nkanza, P., Tétreault, N., Tse, Y.-C., Wong, T., Abdouh, M., & Bernier, G. (2019) · Scientific Reports · doi:10.1038/s41598-018-37444-3 · Cited by 31 · see citing works

Bub1: Escapades in a Cellular World

Williams, G. L., Roberts, T. M., & Gjoerup, O. V. (2007) · Cell Cycle · doi:10.4161/cc.6.14.4493 · Cited by 43 · see citing works

Components of the Spindle Assembly Checkpoint Regulate the Anaphase-Promoting Complex During Meiosis inCaenorhabditis elegans

Stein, K. K., Davis, E. S., Hays, T. S., & Golden, A. (2006) · Genetics · doi:10.1534/genetics.106.059105 · Cited by 41 · see citing works

Osteosarcomagenesis: Modeling Cancer Initiation in the Mouse

Jones, K. B. (2011) · Sarcoma · doi:10.1155/2011/694136 · Cited by 40 · see citing works

Aging-associated truncated form of p53 interacts with wild-type p53 and alters p53 stability, localization, and activity

Moore, L. M., Lu, X., Ghebranious, N., Tyner, S. D., & Donehower, L. A. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2007.10.011 · Cited by 38 · see citing works

Identification of miR‐494 direct targets involved in senescence of human diploid fibroblasts

Comegna, M., Succoio, M., Napolitano, M. A., Vitale, M., DˈAmbrosio, C., Scaloni, A., Passaro, F., Zambrano, N., Cimino, F., & Faraonio, R. (2014) · The FASEB Journal · doi:10.1096/fj.13-239129 · Cited by 38 · see citing works

Decoding and rejuvenating human ageing genomes: Lessons from mosaic chromosomal alterations

Dai, X., & Guo, X. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101342 · Cited by 37 · see citing works

Mitotic Dysfunction Associated with Aging Hallmarks.

Macedo, J. C., Vaz, S., & Logarinho, E. (2017) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-319-57127-0_7 · Cited by 33 · see citing works

TMAP/CKAP2 is essential for proper chromosome segregation

Hong, K. U., Kim, E., Bae, C., & Park, J. (2009) · Cell Cycle · doi:10.4161/cc.8.2.7597 · Cited by 35 · see citing works

How does suppression of IGF-1 signaling by DNA damage affect aging and longevity?

Hinkal, G. W., & Donehower, L. A. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.02.005 · Cited by 33 · see citing works

Genome-Wide DNA Methylation Modified by Soy Phytoestrogens: Role for Epigenetic Therapeutics in Prostate Cancer?

Karslı-Çeppioğlu, S., Ngollo, M., Adjakly, M., Dagdemir, A., Judes, G., Lebert, A., Boiteux, J., Penault-Llorca, F. M., Bignon, Y., Guy, L., et al. (2015) · OMICS A Journal of Integrative Biology · doi:10.1089/omi.2014.0142 · Cited by 32 · see citing works

CINcere Modelling: What Have Mouse Models for Chromosome Instability Taught Us?

Simon, J. E., Bakker, B., & Foijer, F. (2015) · Recent results in cancer research/Recent Results in Cancer Research · doi:10.1007/978-3-319-20291-4_2 · Cited by 31 · see citing works

Vascular Aging in Rodent Models: Contrasting Mechanisms Driving the Female and Male Vascular Senescence

Barros, P. R., Costa, T. J. D., Akamine, E. H., & Tostes, R. C. (2021) · Frontiers in Aging · doi:10.3389/fragi.2021.727604 · Cited by 30 · see citing works

Approaches towards Longevity: Reprogramming, Senolysis, and Improved Mitotic Competence as Anti-Aging Therapies

Pereira, S. M., Ribeiro, R., & Logarinho, E. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20040938 · Cited by 30 · see citing works

BubR1 allelic effects drive phenotypic heterogeneity in mosaic-variegated aneuploidy progeria syndrome

Sieben, C. J., Jeganathan, K. B., Nelson, G. G., Sturmlechner, I., Zhang, C., van Deursen, W. H., Bakker, B., Foijer, F., Li, H., Baker, D. J., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci126863 · Cited by 30 · see citing works

The regulation of sister chromatid cohesion

Losada, A. (2008) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2008.04.003 · Cited by 29 · see citing works

The ARF tumor suppressor prevents chromosomal instability and ensures mitotic checkpoint fidelity through regulation of Aurora B

Britigan, E. M. C., Wan, J., Zasadil, L. M., Ryan, S. D., & Weaver, B. A. A. (2014) · Molecular Biology of the Cell · doi:10.1091/mbc.e14-05-0966 · Cited by 29 · see citing works

Increased longevity of hematopoiesis in continuous bone marrow cultures derived from NOS1 (nNOS, mtNOS) homozygous recombinant negative mice correlates with radioresistance of hematopoietic and marrow stromal cells

Epperly, M. W., Cao, S., Zhang, X., Franicola, D., Shen, H., Greenberger, E. E., Epperly, L. D., & Greenberger, J. S. (2006) · Experimental Hematology · doi:10.1016/j.exphem.2006.09.009 · Cited by 28 · see citing works

The centrosome and mitotic spindle apparatus in cancer and senescence

Schmidt, S., Eßmann, F., Cirstea, I. C., Kuck, F., Thakur, H. C., Singh, M., Kletke, A., Jänicke, R. U., Wiek, C., Hanenberg, H., et al. (2010) · Cell Cycle · doi:10.4161/cc.9.22.13684 · Cited by 27 · see citing works

THE JOURNAL OF CELL BIOLOGY

Baker, D. J., Jeganathan, K. B., Malureanu, L. A., Pérez-Terzic, C. M., & Terzic, A. (2013)

BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice

Baker, D. J., Jeganathan, K. B., Cameron, J. D., Thompson, M., Juneja, S., Kopecka, A., Kumar, R., Jenkins, R. B., de Groen, P. C., Roche, P., et al. (2004) · Nature Genetics · doi:10.1038/ng1382 · Cited by 731 · see citing works

Aging in Check

Dai, W. H., & Wang, X. (2006) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2006.7.pe9 · Cited by 7 · see citing works

Newly identified roles for an old guardian: Profound deficiency of the mitotic spindle checkpoint protein BubR1 leads to early aging and infertility

Kim, M., & Kao, G. D. (2005) · Cancer Biology & Therapy · doi:10.4161/cbt.4.2.1506 · Cited by 10 · see citing works

Haplo-insufficiency of both BubR1 and SGO1 accelerates cellular senescence

Park, S.-H., Xie, S., Rao, C. V., & Dai, W. H. (2016) · Journal of Hematology & Oncology · doi:10.1186/s13045-016-0238-5 · Cited by 4 · see citing works