The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Mouse SYCP2 is required for synaptonemal complex assembly and chromosomal synapsis during male meiosis
Open accessAbstract
During meiosis, the arrangement of homologous chromosomes is tightly regulated by the synaptonemal complex (SC). Each SC consists of two axial/lateral elements (AEs/LEs), and numerous transverse filaments. SC protein 2 (SYCP2) and SYCP3 are integral components of AEs/LEs in mammals. We find that SYCP2 forms heterodimers with SYCP3 both in vitro and in vivo. An evolutionarily conserved coiled coil domain in SYCP2 is required for binding to SYCP3. We generated a mutant Sycp2 allele in mice that lacks the coiled coil domain. The fertility of homozygous Sycp2 mutant mice is sexually dimorphic; males are sterile because of a block in meiosis, whereas females are subfertile with sharply reduced litter size. Sycp2 mutant spermatocytes exhibit failure in the formation of AEs and chromosomal synapsis. Strikingly, the mutant SYCP2 protein localizes to axial chromosomal cores in both spermatocytes and fetal oocytes, but SYCP3 does not, demonstrating that SYCP2 is a primary determinant of AEs/LEs and, thus, is required for the incorporation of SYCP3 into SCs.
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Cites
Meiotic chromosomes: it takes two to tango
Roeder, G. S. (1997) · Genes & Development · doi:10.1101/gad.11.20.2600 · Cited by 805
An abundance of X-linked genes expressed in spermatogonia
Wang, P. J., McCarrey, J. R., Yang, F., & Page, D. C. (2001) · Nature Genetics · doi:10.1038/86927 · Cited by 784
Self-citationPeters, A. H. F. M., Plug, A. W., van Vugt, M. J., & de Boer, P. (1997) · Chromosome Research · doi:10.1023/a:1018445520117 · Cited by 728
Yuan, L., Liu, J.-G., Zhao, J., Brundell, E., Daneholt, B., & Höög, C. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80404-9 · Cited by 714
THE GENETICS AND MOLECULAR BIOLOGY OF THE SYNAPTONEMAL COMPLEX
Page, S. L., & Hawley, R. S. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.19.111301.155141 · Cited by 709
ZIP1 is a synaptonemal complex protein required for meiotic chromosome synapsis
Sym, M., Engebrecht, J., & Roeder, G. S. (1993) · Cell · doi:10.1016/0092-8674(93)90114-6 · Cited by 598
THE SYNAPTONEMAL COMPLEX IN GENETIC SEGREGATION
von Wettstein, D., Rasmussen, S. W., & Holm, P. B. (1984) · Annual Review of Genetics · doi:10.1146/annurev.ge.18.120184.001555 · Cited by 590
Hunt, P. A., & Hassold, T. J. (2002) · Science · doi:10.1126/science.1071907 · Cited by 463
Mouse Sycp1 functions in synaptonemal complex assembly, meiotic recombination, and XY body formation
de Vries, F. A. T., de Boer, E., van den Bosch, M., Baarends, W. M., Ooms, M., Yuan, L., Liu, J.-G., van Zeeland, A. A., Heyting, C., & Pastink, A. (2005) · Genes & Development · doi:10.1101/gad.329705 · Cited by 455
Scherthan, H., Weich, S., Schwegler, H., Heyting, C., Härle, M., & Cremer, T. (1996) · The Journal of cell biology · doi:10.1083/jcb.134.5.1109 · Cited by 431
Cited by
Hermo, L., Pelletier, R. ‐., Cyr, D. G., & Smith, C. E. (2010) · Microscopy Research and Technique · doi:10.1002/jemt.20783 · Cited by 422
He, C., Kraft, P., Chen, C., Buring, J. E., Paré, G., Hankinson, S. E., Chanock, S. J., Ridker, P. M., Hunter, D. J., & Chasman, D. I. (2009) · Nature Genetics · doi:10.1038/ng.385 · Cited by 379
Niu, W., & Spradling, A. C. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2005570117 · Cited by 267
Metadata
- Authors
- Yang, F., Fuente, R. D. L., Leu, N. A., Baumann, C., McLaughlin, K. J., & Wang, P. J.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2006-05-22
- Volume
- 173
- Issue
- 4
- Pages
- 497-507
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2099448734
- Cited by
- 277
- References
- 37
- FWCI
- 10.61
- Type
- journal article
- Language
- en
- Open access
- green
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- Yang, F., Fuente, R. D. L., Leu, N. A., Baumann, C., McLaughlin, K. J., & Wang, P. J. (2006). Mouse SYCP2 is required for synaptonemal complex assembly and chromosomal synapsis during male meiosis. The Journal of Cell Biology. https://doi.org/10.1083/jcb.200603063
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