The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
GPI-anchored receptor clusters transiently recruit Lyn and Gα for temporary cluster immobilization and Lyn activation: single-molecule tracking study 1
Open accessAbstract
The signaling mechanisms for glycosylphosphatidylinositol-anchored receptors (GPI-ARs) have been investigated by tracking single molecules in living cells. Upon the engagement or colloidal gold–induced cross-linking of CD59 (and other GPI-ARs) at physiological levels, CD59 clusters containing three to nine CD59 molecules were formed, and single molecules of Gαi2 or Lyn (GFP conjugates) exhibited the frequent but transient (133 and 200 ms, respectively) recruitment to CD59 clusters, via both protein–protein and lipid–lipid (raft) interactions. Each CD59 cluster undergoes alternating periods of actin-dependent temporary immobilization (0.57-s lifetime; stimulation-induced temporary arrest of lateral diffusion [STALL], inducing IP3 production) and slow diffusion (1.2 s). STALL of a CD59 cluster was induced right after the recruitment of Gαi2. Because both Gαi2 and Lyn are required for the STALL, and because Lyn is constitutively recruited to CD59 clusters, the STALL of CD59 clusters is likely induced by the Gαi2 binding to, and its subsequent activation of, Lyn within the same CD59 cluster.
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Functional rafts in cell membranes
Simons, K., & Ikonen, E. (1997) · Nature · doi:10.1038/42408 · Cited by 9,757
Lipid rafts and signal transduction
Simons, K., & Toomre, D. (2000) · Nature Reviews Molecular Cell Biology · doi:10.1038/35036052 · Cited by 5,371
Srimaroeng, C., Cecile, J. P., Walden, R., & Pritchard, J. B. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350077 · Cited by 2,989
Brown, D. A., & Rose, J. K. (1992) · Cell · doi:10.1016/0092-8674(92)90189-j · Cited by 2,921
Discovery of a Novel, Potent, and Src Family-selective Tyrosine Kinase Inhibitor
Hanke, J. H., Gardner, J. P., Dow, R. L., Changelian, P. S., Brissette, W. H., Weringer, E. J., Pollok, B. A., & Connelly, P. A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.2.695 · Cited by 1,939
Lipid sorting in epithelial cells
Simons, K., & Van Meer, G. (1988) · Biochemistry · doi:10.1021/bi00417a001 · Cited by 1,371
Caveolar endocytosis of simian virus 40 reveals a new two-step vesicular-transport pathway to the ER
Pelkmans, L., Kartenbeck, J., & Helenius, A. (2001) · Nature Cell Biology · doi:10.1038/35074539 · Cited by 1,235
Lipid Domain Structure of the Plasma Membrane Revealed by Patching of Membrane Components
Harder, T., Scheiffele, P., Verkade, P., & Simons, K. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.141.4.929 · Cited by 1,184
Kusumi, A., Sako, Y., & Yamamoto, M. (1993) · Biophysical Journal · doi:10.1016/s0006-3495(93)81253-0 · Cited by 1,053
Self-citationPhospholipids undergo hop diffusion in compartmentalized cell membrane
Fujiwara, T., Ritchie, K., Murakoshi, H., Jacobson, K., & Kusumi, A. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200202050 · Cited by 929
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Simons, K., & Gerl, M. J. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2977 · Cited by 1,234
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Miller, W. L., & Bose, H. S. (2011) · Journal of Lipid Research · doi:10.1194/jlr.r016675 · Cited by 554
Order of lipid phases in model and plasma membranes
Kaiser, H.-J., Lingwood, D., Levental, I., Sampaio, J. L., Kalvodova, L., Rajendran, L., & Simons, K. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908987106 · Cited by 482
Metadata
- Authors
- Suzuki, K. G. N., Fujiwara, T. K., Sanematsu, F., Iino, R., Edidin, M., & Kusumi, A.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2007-05-21
- Volume
- 177
- Issue
- 4
- Pages
- 717-730
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2146255300
- Cited by
- 310
- References
- 48
- FWCI
- 10.90
- Type
- journal article
- Language
- en
- Open access
- green
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- Suzuki, K. G. N., Fujiwara, T. K., Sanematsu, F., Iino, R., Edidin, M., & Kusumi, A. (2007). GPI-anchored receptor clusters transiently recruit Lyn and Gα for temporary cluster immobilization and Lyn activation: single-molecule tracking study 1. The Journal of Cell Biology. https://doi.org/10.1083/jcb.200609174
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