Interferons: Signaling, antiviral and viral evasion

Bonjardim, Cláudio A.; Ferreira, Paulo C.P.; Kroon, Erna G.

doi:10.1016/j.imlet.2008.11.002

Cited by 196interferon and immune responsesImmune Response and InflammationCytokine Signaling Pathways and Interactions

Interferons: Signaling, antiviral and viral evasion

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Bonjardim, Cláudio A., Ferreira, Paulo C.P., Kroon, Erna G.·2009·Immunology Letters

DOI 10.1016/j.imlet.2008.11.002PMC PMC7112942

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Abstract

Interferons (IFNs) were discovered as antiviral agents 50 years ago, and enormous progress has been made since then. Nowadays, IFNs (specifically type I IFNs), have been ascribed as the cytokines that bridge the innate and adaptive immunity soon after the recognition of pathogen-associated molecular patterns (PAMPs) by the infected host. Notably, a unifying mechanism for type I IFN production has been established upon innate immune detection. Thus, TLR 3, 4, 7 and 9 associate endosomal recognition of PAMPs to type I IFN responses, a mechanism that has been shown in plasmacytoid dendritic cells to be dependent on the PI3K/mTOR/S6K pathway. It is worth noting that pathogen recognition triggers a fine-tuned controlled program that not only includes the production of antiviral (IFN) and pro-inflammatory cytokines to initiate the antiviral response but also signals the cessation of the response through the induction of suppressors of cytokine signaling (SOCS). SOCS in turn is under tight regulation of the TAM receptors (protein tyrosine kinase receptors TYRO3, AXL and MER), and activation of which thereby protects the host from the threats of autoimmune diseases.

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Virus-induced secretion of signaling factors mediates the onset of innate and adaptive immunity.
“This is critical from the host perspective, as the virus-induced secretion of signaling factors mediates the onset of innate and adaptive immunity (116).”
From The Impact of Mass Spectrometry–Based Proteomics on Fundamental Discoveries in Virology (2014) · cites this paper as [116]

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Identification of the Zebrafish IFN Receptor: Implications for the Origin of the Vertebrate IFN System
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Dissociation of a MAVS/IPS-1/VISA/Cardif-IKKε Molecular Complex from the Mitochondrial Outer Membrane by Hepatitis C Virus NS3-4A Proteolytic Cleavage
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Acetylation-Dependent Signal Transduction for Type I Interferon Receptor
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Interferon-α Engages the Insulin Receptor Substrate-1 to Associate with the Phosphatidylinositol 3′-Kinase
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Differential Inhibition of Type I Interferon Induction by Arenavirus Nucleoproteins
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The Rac1/p38 Mitogen-activated Protein Kinase Pathway Is Required for Interferon α-dependent Transcriptional Activation but Not Serine Phosphorylation of Stat Proteins
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Cutting Edge: Roles of Caspase-8 and Caspase-10 in Innate Immune Responses to Double-Stranded RNA
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Disruption of Erk-dependent type I interferon induction breaks the myxoma virus species barrier
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The Feedback Phase of Type I Interferon Induction in Dendritic Cells Requires Interferon Regulatory Factor 8
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Virus Infection Triggers SUMOylation of IRF3 and IRF7, Leading to the Negative Regulation of Type I Interferon Gene Expression
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Pentraxins as a key component of innate immunity
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Inhibition of IκB Kinase by Vaccinia Virus Virulence Factor B14
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The p38 MAPK Pathway Mediates the Growth Inhibitory Effects of Interferon-α in BCR-ABL-expressing Cells
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Inhibition of Interferon Regulatory Factor 7 (IRF7)-Mediated Interferon Signal Transduction by the Kaposi's Sarcoma-Associated Herpesvirus Viral IRF Homolog vIRF3
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Evolution of the Class 2 cytokines and receptors, and discovery of new friends and relatives
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Cutting Edge: NF-κB-Activating Kinase-Associated Protein 1 Participates in TLR3/Toll-IL-1 Homology Domain-Containing Adapter Molecule-1-Mediated IFN Regulatory Factor 3 Activation
Sasai, M., Oshiumi, H., Matsumoto, M., Inoue, N., Fujita, F., Nakanishi, M., & Seya, T. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.1.27 · Cited by 135 · see citing works
Ringing the interferon alarm: differential regulation of gene expression at the interface between innate and adaptive immunity
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p38 MAPK enhances STAT1-dependent transcription independently of Ser-727 phosphorylation
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Activation of Protein Kinase Cδ by IFN-γ
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Activation of the p70 S6 Kinase and Phosphorylation of the 4E-BP1 Repressor of mRNA Translation by Type I Interferons
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Interferons (IFNs) are key cytokines in both innate and adaptive antiviral immune responses—and viruses counteract IFN action
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Role of p38α Map Kinase in Type I Interferon Signaling
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Regulatory Effects of Mammalian Target of Rapamycin-activated Pathways in Type I and II Interferon Signaling
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Interferon Regulatory Factor 7 Is Negatively Regulated by the Epstein-Barr Virus Immediate-Early Gene,BZLF-1
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Composition and Assembly of STAT-Targeting Ubiquitin Ligase Complexes: Paramyxovirus V Protein Carboxyl Terminus Is an Oligomerization Domain
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Alternate interferon signaling pathways
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Autophagy and antiviral immunity
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Polymorphisms in TLR2 Are Associated with Increased Viral Shedding and Lesional Rate in Patients with Genital Herpes Simplex Virus Type 2 Infection
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MEKK1 plays a critical role in activating the transcription factor C/EBP-β-dependent gene expression in response to IFN-γ
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Innate Sensors of Microbial Infection
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Interferon-gamma engages the p70 S6 kinase to regulate phosphorylation of the 40S S6 ribosomal protein.
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Selective Roles of MAPKs during the Macrophage Response to IFN-γ
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Toll-like receptors regulation of viral infection and disease☆
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Cytosolic DNA recognition for triggering innate immune responses
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Lethal Encephalitis in Myeloid Differentiation Factor 88-Deficient Mice Infected with Herpes Simplex Virus 1
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SOCS-1 inhibits expression of the antiviral proteins 2',5'-OAS and MxA induced by the novel interferon-lambdas IL-28A and IL-29.
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The interferon signaling network and transcription factor C/EBP-beta.
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Innate recognition of viruses
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Binding of Kaposi's Sarcoma-Associated Herpesvirus K-bZIP to Interferon-Responsive Factor 3 Elements Modulates Antiviral Gene Expression
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Molecular cloning of human interferon cDNA.
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Innate Recognition Network Driving Herpes Simplex Virus-Induced Corneal Immunopathology: Role of the Toll Pathway in Early Inflammatory Events in Stromal Keratitis
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Regulation of IRF7 through cell type-specific protein stability
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Toll‐like receptor signaling and IRF transcription factors
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Protein Kinase Cδ Regulates Apoptosis via Activation of STAT1
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SOCS1 Silencing Enhances Antitumor Activity of Type I IFNs by Regulating Apoptosis in Neuroendocrine Tumor Cells
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TRAF3: A New Regulator of Type I Interferons
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The Med1 Subunit of Transcriptional Mediator Plays a Central Role in Regulating CCAAT/Enhancer-binding Protein-β-driven Transcription in Response to Interferon-γ*
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Role of Interferon Regulatory Factor 3 in Type I Interferon Responses in Rotavirus-Infected Dendritic Cells and Fibroblasts
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Interferons and scleroderma—A new clue to understanding the pathogenesis of scleroderma?
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Antiviral activity of type I interferons and interleukins 29 and 28a (type III interferons) against Apeu virus
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Characterization of alpha-enolase as an interferon-alpha 2 alpha 1 regulated gene
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The HCV Life Cycle: In vitro Tissue Culture Systems and Therapeutic Targets
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Authors: Bonjardim, C. A., Ferreira, P. C. P., & Kroon, E. G.
Affiliations: Universidade Federal de Minas Gerais (BR)
Corresponding author: Bonjardim, Cláudio A.
ORCID: Bonjardim, Cláudio A.
Kroon, Erna G.
Venue: Immunology Letters
Publisher: Elsevier BV
Published: 2009-01
Volume: 122
Issue: 1
Pages: 1-11
ISSN: 0165-2478 (ISSN-L)
DOI: 10.1016/j.imlet.2008.11.002
PMC: PMC7112942
OpenAlex: W2020464368
Cited by: 196
References: 163
Citations by year: 2026: 3 · 2025: 4 · 2024: 7 · 2023: 5 · 2022: 11 · 2021: 5 · 2020: 6 · 2019: 10 · 2018: 2 · 2017: 11 · 2016: 11 · 2015: 15 · 2014: 16 · 2013: 19 · 2012: 23
FWCI: 1.10
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Immunology Letters (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
Keywords: interferon, type I interferon, antiviral signaling, viral evasion, innate immunity, adaptive immunity, pathogen-associated molecular patterns, Toll-like receptors, plasmacytoid dendritic cells, suppressor of cytokine signaling, TAM receptors, autoimmune disease
MeSH terms: Animals, Humans, Immunity, Innate, Interferon Type I, Endosomes, Virus Diseases, Signal Transduction, Feedback, Physiological, Suppressor of Cytokine Signaling Proteins, Toll-Like Receptors, Host-Pathogen Interactions

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Interferons: Signaling, antiviral and viral evasion

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