The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Maturation of active zone assembly by Drosophila Bruchpilot
Open accessAbstract
Synaptic vesicles fuse at active zone (AZ) membranes where Ca2+ channels are clustered and that are typically decorated by electron-dense projections. Recently, mutants of the Drosophila melanogaster ERC/CAST family protein Bruchpilot (BRP) were shown to lack dense projections (T-bars) and to suffer from Ca2+ channel–clustering defects. In this study, we used high resolution light microscopy, electron microscopy, and intravital imaging to analyze the function of BRP in AZ assembly. Consistent with truncated BRP variants forming shortened T-bars, we identify BRP as a direct T-bar component at the AZ center with its N terminus closer to the AZ membrane than its C terminus. In contrast, Drosophila Liprin-α, another AZ-organizing protein, precedes BRP during the assembly of newly forming AZs by several hours and surrounds the AZ center in few discrete punctae. BRP seems responsible for effectively clustering Ca2+ channels beneath the T-bar density late in a protracted AZ formation process, potentially through a direct molecular interaction with intracellular Ca2+ channel domains.
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Self-citationBruchpilot Promotes Active Zone Assembly, Ca 2+ Channel Clustering, and Vesicle Release
Kittel, R. J., Wichmann, C., Rasse, T. M., Fouquet, W., Schmidt, M., Schmid, A., Wagh, D. A., Pawlu, C., Kellner, R. R., Willig, K. I., et al. (2006) · Science · doi:10.1126/science.1126308 · Cited by 772
Self-citationα-Neurexins couple Ca2+ channels to synaptic vesicle exocytosis
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Calcium Channel Regulation and Presynaptic Plasticity
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The architecture of active zone material at the frog's neuromuscular junction
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Synaptic development: insights from Drosophila
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SYD-2 Liprin-α organizes presynaptic active zone formation through ELKS
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Hierarchical assembly of presynaptic components in defined C. elegans synapses
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RIM-Binding Protein, a Central Part of the Active Zone, Is Essential for Neurotransmitter Release
Liu, K. S. Y., Siebert, M., Mertel, S., Knoche, E., Wegener, S., Wichmann, C., Matkovic, T., Muhammad, K., Depner, H., Mettke, C., et al. (2011) · Science · doi:10.1126/science.1212991 · Cited by 306
Self-citationA Syd-1 homologue regulates pre- and postsynaptic maturation in Drosophila
Owald, D., Fouquet, W., Schmidt, M., Wichmann, C., Mertel, S., Depner, H., Christiansen, F., Zube, C., Quentin, C., Körner, J., et al. (2010) · Journal of Cell Biology · doi:10.1083/jcb.200908055 · Cited by 191
Self-citationA single pair of neurons links sleep to memory consolidation in Drosophila melanogaster
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Metadata
- Authors
- Fouquet, W., Owald, D., Wichmann, C., Mertel, S., Depner, H., Dyba, M., Hallermann, S., Kittel, R. J., Eimer, S., & Sigrist, S. J.
- Venue
- Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2009-07-13
- Volume
- 186
- Issue
- 1
- Pages
- 129-145
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2151889253
- Cited by
- 406
- References
- 9
- FWCI
- 10.41
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Fouquet, W., Owald, D., Wichmann, C., Mertel, S., Depner, H., Dyba, M., Hallermann, S., Kittel, R. J., Eimer, S., & Sigrist, S. J. (2009). Maturation of active zone assembly by Drosophila Bruchpilot. Journal of Cell Biology. https://doi.org/10.1083/jcb.200812150
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