The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
S-glutathionylation activates STIM1 and alters mitochondrial homeostasis
Open accessAbstract
Oxidant stress influences many cellular processes, including cell growth, differentiation, and cell death. A well-recognized link between these processes and oxidant stress is via alterations in Ca2+ signaling. However, precisely how oxidants influence Ca2+ signaling remains unclear. Oxidant stress led to a phenotypic shift in Ca2+ mobilization from an oscillatory to a sustained elevated pattern via calcium release–activated calcium (CRAC)–mediated capacitive Ca2+ entry, and stromal interaction molecule 1 (STIM1)– and Orai1-deficient cells are resistant to oxidant stress. Functionally, oxidant-induced Ca2+ entry alters mitochondrial Ca2+ handling and bioenergetics and triggers cell death. STIM1 is S-glutathionylated at cysteine 56 in response to oxidant stress and evokes constitutive Ca2+ entry independent of intracellular Ca2+ stores. These experiments reveal that cysteine 56 is a sensor for oxidant-dependent activation of STIM1 and demonstrate a molecular link between oxidant stress and Ca2+ signaling via the CRAC channel.
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Cites
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Store-Operated Calcium Channels
Parekh, A. B., & Putney, J. W. (2005) · Physiological Reviews · doi:10.1152/physrev.00057.2003 · Cited by 2,089
Calcium signalling in lymphocyte activation and disease
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Cited by
Calcium and ROS: A mutual interplay
Görlach, A., Bertram, K., Hudecova, S., & Krizanova, O. (2015) · Redox Biology · doi:10.1016/j.redox.2015.08.010 · Cited by 1,546
Store-Operated Calcium Channels
Prakriya, M., & Lewis, R. S. (2015) · Physiological Reviews · doi:10.1152/physrev.00020.2014 · Cited by 1,239
Interrelation between ROS and Ca2+ in aging and age-related diseases
Madreiter-Sokolowski, C. T., Thomas, C., & Ristow, M. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101678 · Cited by 365
SARAF Inactivates the Store Operated Calcium Entry Machinery to Prevent Excess Calcium Refilling
Palty, R., Raveh, A., Kaminsky, I., Meller, R., & Reuveny, E. (2012) · Cell · doi:10.1016/j.cell.2012.01.055 · Cited by 273
Marchi, S., Giorgi, C., Galluzzi, L., & Pinton, P. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.04.017 · Cited by 235
Metadata
- Authors
- Hawkins, B. J., Irrinki, K. M., Mallilankaraman, K., Lien, Y.-C., Wang, Y., Bhanumathy, C. D., Subbiah, R., Ritchie, M. F., Soboloff, J., Baba, Y., Kurosaki, T., Joseph, S. K., Gill, D. L., & Madesh, M.
- Venue
- Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2010-08-02
- Volume
- 190
- Issue
- 3
- Pages
- 391-405
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2105342942
- Cited by
- 226
- References
- 6
- FWCI
- 9.26
- Type
- journal article
- Language
- en
- Open access
- green
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- Hawkins, B. J., Irrinki, K. M., Mallilankaraman, K., Lien, Y.-C., Wang, Y., Bhanumathy, C. D., Subbiah, R., Ritchie, M. F., Soboloff, J., Baba, Y., Kurosaki, T., Joseph, S. K., Gill, D. L., & Madesh, M. (2010). S-glutathionylation activates STIM1 and alters mitochondrial homeostasis. Journal of Cell Biology. https://doi.org/10.1083/jcb.201004152
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