Conserved nucleolar stress at the onset of cell death
Open accessAbstract
Cell death pervasiveness among multicellular eukaryotes suggested that some core steps of cell death may be conserved. This could be addressed by comparing the course of cell death in organisms belonging to distinct eukaryotic kingdoms. A search for early cell death events in a protist revealed nucleolar disorganization similar to the nucleolar stress often reported in dying animal cells. This indicated a conserved role for the nucleolus at the onset of eukaryotic cell death and leads one to consider the course of cell death as a succession of unequally conserved modules.
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Similar nucleolar disorganization/block has been observed in mammalian and plant cells undergoing multiple forms of RCD, suggesting nucleolar stress may play a key role in RCD execution across species.
“A similar process has also been observed in mammalian and plant cells succumbing to multiple forms of RCD, perhaps suggesting that nucleolar stress plays a key role in RCD execution across different species [1051].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [1051]
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- Authors
- Golstein, P.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Golstein, Pierre
- ORCID
- Golstein, Pierre
- Venue
- The FEBS Journal
- Publisher
- Wiley
- Published
- 2017-05-18
- Volume
- 284
- Issue
- 22
- Pages
- 3791-3800
- ISSN
- 1742-464X (ISSN-L)
- 1742-4658
- OpenAlex
- W2609364851
- Cited by
- 7
- References
- 80
- Citations by year
- 2022: 1 · 2021: 1 · 2020: 1 · 2018: 3 · 2017: 1
- FWCI
- 0.13
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- FEBS Journal (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Association pour la Recherche contre le Cancer (PJA 20141201684)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Keywords
- cell death, nucleolar stress, nucleolus, protists, evolutionary conservation
- MeSH terms
- Animals, Cell Nucleolus, Humans, Nuclear Proteins, Stress, Physiological, Cell Death
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