A molecular signature for anastasis, recovery from the brink of apoptotic cell death
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Abstract
During apoptosis, executioner caspase activity has been considered a point of no return. However, recent studies show that cells can survive caspase activation following transient apoptotic stimuli, a process called anastasis. To identify a molecular signature, we performed whole-transcriptome RNA sequencing of untreated, apoptotic, and recovering HeLa cells. We found that anastasis is an active, two-stage program. During the early stage, cells transition from growth-arrested to growing. In the late stage, HeLa cells change from proliferating to migratory. Recovering cells also exhibited prolonged elevation of proangiogenic factors. Strikingly, some early-recovery mRNAs, including Snail, were elevated first during apoptosis, implying that dying cells poise to recover, even while under apoptotic stress. Snail was also required for recovery. This study reveals similarities in the anastasis genes, pathways, and cell behaviors to those activated in wound healing and identifies a repertoire of potential targets for therapeutic manipulation.
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At least some cells exposed to transient apoptotic stimuli appear to survive MOMP affecting a limited number of mitochondria and the partial activation of executioner caspases by a process called anastasis.
“Finally, at least some cells exposed to transient apoptotic stimuli appear to survive MOMP affecting a limited number of mitochondria and the partial activation of executioner caspases by a hitherto poorly characterized process called anastasis (most likely constituting a robust adaptative response upstream of the boundary between cellular life and death) [226–228].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [227]
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- Authors
- Sun, G., Guzman, E., Balasanyan, V., Conner, C. M., Wong, K., Zhou, H. R., Kosik, K. S., & Montell, D. J.
- Affiliations
- University of California, Santa Barbara (US)
- Corresponding author
- Montell, Denise J.
- ORCID
- Venue
- Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2017-08-02
- Volume
- 216
- Issue
- 10
- Pages
- 3355-3368
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- PMC
- PMC5626555
- OpenAlex
- W2949919857
- Cited by
- 151
- References
- 57
- Citations by year
- 2026: 12 · 2025: 19 · 2024: 19 · 2023: 19 · 2022: 21 · 2021: 12 · 2020: 19 · 2019: 15 · 2018: 12 · 2017: 3
- FWCI
- 5.47
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- The Journal of Cell Biology (publishedVersion, cc-by-nc-sa)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institutes of Health (DP1OD019313-01, 5DP1CA195760-02)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Keywords
- anastasis, apoptosis, caspase activation, cell recovery, HeLa cells, snails, angiogenic factors, cell migration, wound healing, gene expression signatures, cell proliferation
- MeSH terms
- Snail Family Transcription Factors, Cell Movement, HeLa Cells, Humans, Wound Healing, Apoptosis, Cell Proliferation
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