Cited by 46Axon Guidance and Neuronal SignalingBiotin and Related StudiesNeurogenesis and neuroplasticity mechanisms

The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis

Open access
Menon, Shalini, Goldfarb, Dennis, Ho, Chris T., Cloer, Erica W., Boyer, Nicholas P., Hardie, Christopher, Bock, Andrew J., Johnson, Emma C. +3 more·2021·Molecular Biology of the Cell

Published version of a preprint

Abstract

Unbiased proximity biotinylation revealed an overlapping interactome of E3 ubiquitin ligases TRIM9 and TRIM67. The interactome is enriched in proteins that regulate neuronal growth and arborization, cytoskeletal dynamics, and membrane remodeling. One validated interactor, Myo16, plays a role in netrin-dependent axon branching with TRIM9 and TRIM67.

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Crossref · 10.1091/mbc.e20-10-0622

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  • Several CNS-specific E3 ligases have emerged, such as RNF182 and TRIM9.

    “several central nervous system (CNS)-specific E3 ligases have emerged, such as RNF182 (ref.148) and tripartite motif-containing protein 9 (TRIM9)149”

    From PROTAC targeted protein degraders: the past is prologue (2022) · cites this paper as [149]

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Authors
Menon, S., Goldfarb, D., Ho, C. T., Cloer, E. W., Boyer, N. P., Hardie, C., Bock, A. J., Johnson, E. C., Anil, J., Major, M. B., & Gupton, S. L.
Affiliations
University of North Carolina at Chapel Hill (US)
Corresponding author
Gupton, Stephanie L.
Venue
Molecular Biology of the Cell
Published
2021-02-15
Volume
32
Issue
4
Pages
314-330
ISSN
  • 1059-1524 (ISSN-L)
  • 1939-4586
OpenAlex
W3114171701
Cited by
46
References
110
Citations by year
2026: 5 · 2025: 7 · 2024: 14 · 2023: 5 · 2022: 12 · 2021: 1 · 2020: 2
FWCI
2.29
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Molecular Biology of the Cell (publishedVersion)
  • bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by-nc-sa)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Institute of Mental Health (R21MH109653)
  • National Cancer Institute (P30CA016086)
  • National Institute of General Medical Sciences (R35GM135160)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Biotin and Related Studies
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
TRIM9, protein-protein interaction, cortical neurons, unconventional myosins, filopodia, growth cones, netrin-1, axon branching, cytoskeleton regulation, exocytosis, synaptic regulation
MeSH terms
Tripartite Motif Proteins, Animals, Axons, Cytoskeletal Proteins, Female, Hippocampus, Male, Mice, Inbred C57BL, Morphogenesis, Nerve Tissue Proteins, Neurons, Pseudopodia, Mice, Knockout, Growth Cones, Protein Interaction Mapping, Ubiquitin-Protein Ligases, Adaptor Proteins, Signal Transducing, Mice, Protein Interaction Maps

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