The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis
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Abstract
Unbiased proximity biotinylation revealed an overlapping interactome of E3 ubiquitin ligases TRIM9 and TRIM67. The interactome is enriched in proteins that regulate neuronal growth and arborization, cytoskeletal dynamics, and membrane remodeling. One validated interactor, Myo16, plays a role in netrin-dependent axon branching with TRIM9 and TRIM67.
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Several CNS-specific E3 ligases have emerged, such as RNF182 and TRIM9.
“several central nervous system (CNS)-specific E3 ligases have emerged, such as RNF182 (ref.148) and tripartite motif-containing protein 9 (TRIM9)149”
From PROTAC targeted protein degraders: the past is prologue (2022) · cites this paper as [149]
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TRIM67 regulates exocytic mode and neuronal morphogenesis via SNAP47
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Self-citationTwo subunits of the exocyst, Sec3p and Exo70p, can function exclusively on the plasma membrane
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Coronin-1 and Calcium Signaling Governs Sympathetic Final Target Innervation
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Genome‐wide association study of atypical psychosis
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Combinatorial morphogenesis of dendritic spines and filopodia by SPAR and α-actinin2
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Emergent Role of Coronin-1a in Neuronal Signaling
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TRIM9-dependent ubiquitination of DCC constrains kinase signaling, exocytosis, and axon branchingPreprint
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PROTAC targeted protein degraders: the past is prologue
Békés, M., Langley, D. R., & Crews, C. M. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00371-6 · Cited by 3,395 · see citing works
- Authors
- Menon, S., Goldfarb, D., Ho, C. T., Cloer, E. W., Boyer, N. P., Hardie, C., Bock, A. J., Johnson, E. C., Anil, J., Major, M. B., & Gupton, S. L.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Gupton, Stephanie L.
- ORCID
- Venue
- Molecular Biology of the Cell
- Published
- 2021-02-15
- Volume
- 32
- Issue
- 4
- Pages
- 314-330
- ISSN
- 1059-1524 (ISSN-L)
- 1939-4586
- PMC
- PMC8098814
- OpenAlex
- W3114171701
- Cited by
- 46
- References
- 110
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 14 · 2023: 5 · 2022: 12 · 2021: 1 · 2020: 2
- FWCI
- 2.29
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Licence
- cc-by
- Locations
- Molecular Biology of the Cell (publishedVersion)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (R21MH109653)
- National Cancer Institute (P30CA016086)
- National Institute of General Medical Sciences (R35GM135160)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Biotin and Related Studies
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- TRIM9, protein-protein interaction, cortical neurons, unconventional myosins, filopodia, growth cones, netrin-1, axon branching, cytoskeleton regulation, exocytosis, synaptic regulation
- MeSH terms
- Tripartite Motif Proteins, Animals, Axons, Cytoskeletal Proteins, Female, Hippocampus, Male, Mice, Inbred C57BL, Morphogenesis, Nerve Tissue Proteins, Neurons, Pseudopodia, Mice, Knockout, Growth Cones, Protein Interaction Mapping, Ubiquitin-Protein Ligases, Adaptor Proteins, Signal Transducing, Mice, Protein Interaction Maps
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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