DIVISION OF GIANT MITOCHONDRIA DURING RECOVERY FROM CUPRIZONE INTOXICATION
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Giant mitochondria may be induced in mouse hepatocytes either by riboflavin deficiency (30) or by addition of the copper-chelating agent, cuprizone (27, 28), to the diet. In both cases, the
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Cuprizone selectively affects oligodendrocytes.
“Nevertheless, a consensus seems to be that cuprizone selectively affects oligodendrocytes.”
From Strain differences in cuprizone induced demyelination (2017) · cites this paper as [19]
The Introduction and Results (pp. 266–267) describe cuprizone-induced changes in mouse hepatocytes, and the Summary reports greatly enlarged hepatic mitochondria in cuprizone-fed mice. The paper does not discuss oligodendrocytes; its finding of an effect in liver cells runs contrary to the unqualified claim that cuprizone selectively affects oligodendrocytes. (LLM, conf=0.84)
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Self-citation
- Authors
- Tandler, B., & Hoppel, C. L.
- Affiliations
- Case Western Reserve University (US)
- ORCID
- Hoppel, Charles L.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 1973-01-01
- Volume
- 56
- Issue
- 1
- Pages
- 266-272
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- PMC
- PMC2108826
- OpenAlex
- W1968298994
- Cited by
- 75
- References
- 15
- Citations by year
- 2022: 1 · 2020: 2 · 2019: 1 · 2018: 3 · 2017: 2 · 2016: 2 · 2015: 1 · 2014: 3 · 2013: 4 · 2012: 1
- FWCI
- 3.50
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- cc-by-nc-sa
- Locations
- The Journal of Cell Biology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Keywords
- giant mitochondria, cuprizone, hepatocytes, mitochondrial division, copper chelation, riboflavin deficiency, copper toxicity
- MeSH terms
- Animals, Chelating Agents, Cyclohexanes, Diet, Hydrazones, Ketones, Liver, Male, Mice, Inbred Strains, Microscopy, Electron, Mitochondria, Liver, Oxalates, Staining and Labeling, Time Factors, Mice
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