The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
A nuclear antigen associated with cell proliferation and blast transformation.
Open accessAbstract
A nuclear antigen associated with cell proliferation (proliferating cell nuclear antigen-PCNA) and blast transformation is recognized by autoantibodies in the sera of some patients with systemic lupus erythematosus. This autoantibody is a precipitating antibody and also reacts in immunofluorescence, staining the nucleoplasm of proliferating and blast-transformed cells. The autoantibody was used as a reagent to determine the distribution of PCNA in a synchronized continuous B lymphoid cell line (WiL-2) and in mitogen-induced blast-transformed lymphocytes. In WiL-2 cells, PCNA was detected as speckled nucleoplasmic staining in G1, S, and G2 phases of the cell cycle. In addition, during late G1 and early S phases, PCNA was also detected in the nucleolus. During mitogen-induced blast transformation of lymphocytes, PCNA was noticed in the nucleolus before the initiation of DNA synthesis and later became nucleoplasmic with disappearance of nucleolar staining. These studies demonstrate that the relationship of PCNA to proliferation and blast transformation may be associated with events related to DNA synthesis in these cells.
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Citations
Cites
Separation of leukocytes from blood and bone marrow
Bøyum, A. (1968) · Scandinavian Journal of Clinical and Laboratory Investigation · Cited by 2,696
Avrameas, S., & Ternynck, T. (1969) · Immunochemistry · doi:10.1016/0019-2791(69)90178-5 · Cited by 1,462
Autoantibody to a nuclear antigen in proliferating cells
Miyachi, K., Fritzler, M. J., & Tan, E. M. (1978) · The Journal of Immunology · doi:10.4049/jimmunol.121.6.2228 · Cited by 874
Self-citationAutoantibody to centromere (kinetochore) in scleroderma sera.
Moroi, Y., Peebles, C., Fritzler, M. J., Steigerwald, J., & Tan, E. M. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.3.1627 · Cited by 729
Self-citation(2001) · Classic Papers in Rheumatology · doi:10.3109/9780203214237-25 · Cited by 550
Tan, E. M., & Kunkel, H. G. (1966) · The Journal of Immunology · doi:10.4049/jimmunol.96.3.464 · Cited by 481
Self-citationSynchronization of mammalian cells in vitro by inhibition of the DNA synthesis
Galavazi, G., & Bootsma, D. (1966) · Experimental Cell Research · doi:10.1016/s0014-4827(66)80150-7 · Cited by 88
Cited by
Gerdes, J., Schwab, U., Lemke, H., & Stein, H. (1983) · International Journal of Cancer · doi:10.1002/ijc.2910310104 · Cited by 2,788
Nair, A., & Bonneau, R. H. (2006) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2005.09.012 · Cited by 392
Galand, P., & Degraef, C. (1989) · Cell Proliferation · doi:10.1111/j.1365-2184.1989.tb00223.x · Cited by 288
Metadata
- Authors
- Takasaki, Y., Deng, J. S., & Tan, E. M.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1981-12-01
- Volume
- 154
- Issue
- 6
- Pages
- 1899-1909
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2039524691
- Cited by
- 329
- References
- 7
- FWCI
- 6.88
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Takasaki, Y., Deng, J. S., & Tan, E. M. (1981). A nuclear antigen associated with cell proliferation and blast transformation. The Journal of experimental medicine. https://doi.org/10.1084/jem.154.6.1899
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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