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Interleukin 1 (IL-1) induces biosynthesis and cell surface expression of procoagulant activity in human vascular endothelial cells.
Open accessAbstract
Human monocyte-derived interleukin 1 (IL-1) was found to be a potent inducer of procoagulant activity in cultured human vascular endothelium. IL-1-induced human umbilical vein endothelial cell procoagulant activity (HEC-PCA) was transiently expressed, manifest in intact cell monolayers, and required protein synthesis. Data obtained with coagulation factor-deficient plasma and a goat anti-human apoprotein III antiserum suggested that most, if not all, of IL-1-induced endothelial cell procoagulant activity is tissue factor-like. IL-1 induction of HEC-PCA may be important in the pathogenesis of intravascular coagulation in a variety of immunological and inflammatory conditions.
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Metadata
- Authors
- Bevilacqua, M. P., Pober, J. S., Majeau, G. R., Cotran, R. S., & Gimbrone, M. A.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1984-08-01
- Volume
- 160
- Issue
- 2
- Pages
- 618-623
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2110623508
- Cited by
- 935
- References
- 0
- FWCI
- 22.00
- Type
- journal article
- Language
- en
- Open access
- bronze
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