The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
The macrophage response to central and peripheral nerve injury. A possible role for macrophages in regeneration.
Open accessAbstract
Using mAbs and immunocytochemistry we have examined the response of macrophages (M phi) after crush injury to the sciatic or optic nerve in the mouse and rat. We have established that large numbers of M phi enter peripheral nerves containing degenerating axons; the M phi are localized to the portion containing damaged axons, and they phagocytose myelin. The period of recruitment of the M phi in the peripheral nerve is before and during the period of maximal proliferation of the Schwann cells. In contrast, the degenerating optic nerve attracts few M phi, and the removal of myelin is much slower. These results show the clearly different responses of M phi to damage in the central and peripheral nervous systems, and suggest that M phi may be an important component of subsequent repair as well as myelin degradation.
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Citations
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Perry, V. H., Hume, D. A., & Gordon, S. (1985) · Neuroscience · doi:10.1016/0306-4522(85)90215-5 · Cited by 902
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Metadata
- Authors
- Perry, V. H., Brown, M. C., & Gordon, S.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1987-04-01
- Volume
- 165
- Issue
- 4
- Pages
- 1218-1223
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2122305954
- Cited by
- 604
- References
- 1
- FWCI
- 4.92
- Type
- journal article
- Language
- en
- Open access
- green
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- Perry, V. H., Brown, M. C., & Gordon, S. (1987). The macrophage response to central and peripheral nerve injury. A possible role for macrophages in regeneration. The Journal of experimental medicine. https://doi.org/10.1084/jem.165.4.1218
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
