The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Macrophages secrete a novel heparin-binding protein with inflammatory and neutrophil chemokinetic properties.
Open accessAbstract
We report the identification and purification of a new inflammatory monokine synthesized by the macrophage tumor cell line RAW 264.7 in response to endotoxin. This monokine, which we term "macrophage inflammatory protein" (MIP), is a doublet with an apparent molecular mass of approximately 8,000 daltons on SDS-PAGE but forms aggregates of greater than 2 x 10(6) daltons as assessed by gel filtration. Partial NH2-terminal amino acid sequence data reveal no significant homology with any previously described protein. Although the monokine is anionic under physiological conditions, it is one of two major macrophage-secreted proteins that bind to heparin at high salt concentrations. At 100 ng/ml or greater, MIP is chemokinetic for human polymorphonuclear cells and triggers hydrogen peroxide production. Subcutaneous injection of 10 ng or greater of MIP into footpads of C3H/HeJ mice elicits an inflammatory response, characterized by neutrophil infiltration. These findings suggest that MIP is an endogenous mediator that may play a role in the host responses that occur during endotoxemia and other inflammatory events.
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Self-citation
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Neutrophils and immunity: challenges and opportunities
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NADPH oxidases: An overview from structure to innate immunity-associated pathologies
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Localization of a human T-cell-specific gene, RANTES (D17S136E), to chromosome 17q11.2-q12
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Inhibition of brain cyclooxygenase-2 activity and the antipyretic action of nimesulide
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Lysozyme-Induced Transcriptional Regulation of TNF-α Pathway Genes in Cells of the Monocyte Lineage
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Metadata
- Authors
- Wolpe, S. D., Davatelis, G., Sherry, B., Beutler, B., Hesse, D. G., Nguyen, H. T., Moldawer, L. L., Nathan, C. F., Lowry, S. F., & Cerami, A.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1988-02-01
- Volume
- 167
- Issue
- 2
- Pages
- 570-581
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2104057569
- Cited by
- 571
- References
- 2
- FWCI
- 13.00
- Type
- journal article
- Language
- en
- Open access
- bronze
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