Cited by 457Nitric Oxide and Endothelin EffectsImmune cells in cancerNeutrophil, Myeloperoxidase and Oxidative Mechanisms

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Activated murine macrophages secrete a metabolite of arginine with the bioactivity of endothelium-derived relaxing factor and the chemical reactivity of nitric oxide

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Stuehr, D J, Gross, S S, Sakuma, I, Levi, R, Nathan, C F·1989·The Journal of experimental medicine

DOI 10.1084/jem.169.3.1011PMC PMC2189276

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Abstract

L-arginine-dependent synthesis of nitrite (NO2-) and nitrate (NO3-) by macrophages correlates with and is required for their execution of nonspecific cytotoxicity toward some tumor cells and microbes. However, the bioactive L-arginine metabolites responsible for cytotoxicity are unknown. Mammalian endothelial cells have recently been shown to release nitric oxide (NO.); we therefore determined if this reactive metabolite was synthesized by activated murine macrophages. Macrophage-derived NO. was detected by two independent methods: a bioassay for NO.-mediated relaxation of preconstricted rings of rabbit aorta; and a spectroscopic measurement of the reaction of NO. with clostridial ferredoxin, an Fe-S protein. After activation with IFN-gamma and LPS, macrophages continuously secreted a substance that relaxed rabbit aortic rings denuded of endothelium. Production of the vasorelaxant was enhanced by 0.5 mM L-arginine and inhibited reversibly by NG-methylated L-arginine analogs that block macrophage NO2-/NO3- synthesis. The vasorelaxant was scavenged by ferrous myoglobin, was labile, and was neither NO2- nor a cyclooxygenase metabolite. Activated M phi also secreted a substance that bleached Fd, a reaction carried out by NO. and NO2, but not NO2-. Macrophage bleaching of Fd correlated directly with time, cell number, and concomitant NO2-/NO3- production, required L-arginine, and was independent of reactive oxygen intermediates. Thus, activated murine M phi release NO. and/or a closely related, highly reactive nitrogen oxide such as NO2, during their conversion of L-arginine to NO2-/NO3-. NO. and NO2 may mediate L-arginine-dependent pathologic effects of M phi, as well as physiologic effects not previously considered for this widely distributed cell type.

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Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
Palmer, R. M. J., Ferrige, A. G., & Moncada, S. (1987) · Nature · doi:10.1038/327524a0 · Cited by 10,704
Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.
Ignarro, L. J., Buga, G. M., Wood, K. S., Byrns, R. E., & Chaudhuri, G. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.24.9265 · Cited by 5,074
Vascular endothelial cells synthesize nitric oxide from L-arginine
Palmer, R. M. J., Ashton, D., & Moncada, S. (1988) · Nature · doi:10.1038/333664a0 · Cited by 4,786
Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production.
Ding, A. H., Nathan, C., & Stuehr, D. J. (1988) · The Journal of Immunology · doi:10.4049/jimmunol.141.7.2407 · Cited by 2,840
Self-citation
Macrophage cytotoxicity: role for L-arginine deiminase and imino nitrogen oxidation to nitrite
Hibbs, J. B., Taintor, R. R., & Vavrin, Z. (1987) · Science · doi:10.1126/science.2432665 · Cited by 1,527
L-arginine is the physiological precursor for the formation of nitric oxide in endothelium-dependent relaxation
Palmer, R. M. J., Rees, D. D., Ashton, D. S., & Moncada, S. (1988) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(88)81362-7 · Cited by 1,348
Selective blockade of endothelium-dependent and glyceryl trinitrate-induced relaxation by hemoglobin and by methylene blue in the rabbit aorta.
Martin, W., Villani, G. M., Jothianandan, D., & Furchgott, R. F. (1985) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)20898-9 · Cited by 1,259
Mammalian nitrate biosynthesis: mouse macrophages produce nitrite and nitrate in response to Escherichia coli lipopolysaccharide.
Stuehr, D. J., & Marletta, M. A. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.22.7738 · Cited by 1,126
Self-citation
L-arginine is required for expression of the activated macrophage effector mechanism causing selective metabolic inhibition in target cells.
Hibbs, J. B., Vavrin, Z., & Taintor, R. R. (1987) · The Journal of Immunology · doi:10.4049/jimmunol.138.2.550 · Cited by 938
The Role of Endothelium in the Responses of Vascular Smooth Muscle to Drugs
Furchgott, R. F. (1984) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.24.040184.001135 · Cited by 937

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NO accounts completely for the oxygenated nitrogen species generated by enzymic l -arginine oxygenation
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Colocalization of vasoactive intestinal peptide and nitric oxide synthase in neurons of the ferret trachea
Dey, R. D., Mayer, B., & Said, S. I. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90578-4 · Cited by 71
NG-Amino-L-arginine: A new potent antagonist of L-arginine-mediated endothelium-dependent relaxation
Fukuto, J. M., Wood, K. S., Byrns, R. E., & Ignarro, L. J. (1990) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(90)92343-x · Cited by 71
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(2000) · doi:10.1002/1096-9896(2000)9999:9999 · Cited by 70
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Expression of interferon-beta during the triggering phase of macrophage cytocidal activation. Evidence for an autocrine/paracrine role in the regulation of this state.
Riches, D. W. H., & Underwood, G. A. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54298-8 · Cited by 67
NG-methyl-L-arginine causes endothelium-dependent contraction and inhibition of cyclic GMP formation in artery and vein.
Gold, M. E., Wood, K. S., Byrns, R. E., Fukuto, J. M., & Ignarro, L. J. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.12.4430 · Cited by 67
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Zheng, Q., Bonoiu, A. C., Ohulchanskyy, T. Y., He, G. S., & Prasad, P. N. (2008) · Molecular Pharmaceutics · doi:10.1021/mp700117s · Cited by 65
GA-binding protein is involved in altered expression of ribosomal protein L32 gene
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Khair‐El‐Din, T. A., Sicher, S. C., Vázquez, M. A., Chung, G. W., Stallworth, K. A., Kitamura, K., Miller, R. T., & Lu, C. Y. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.3.1241 · Cited by 65
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Punturieri, A., Alviani, R. S., Polak, T., Copper, P., Sonstein, J., & Curtis, J. L. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.2.1033 · Cited by 62
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Bates, J. N. (1992) · Neuroprotocols · doi:10.1016/1058-6741(92)90045-y · Cited by 62
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IFN-γ–Dependent Activation of Macrophages during Experimental Infections by Mycobacterium ulcerans Is Impaired by the Toxin Mycolactone
Torrado, E., Fraga, A. G., Logarinho, E., Martins, T. G., Carmona, J. A., Gama, J. B., Carvalho, M. A., Proença, M. F. R. P., Castro, A. G., & Pedrosa, J. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0902717 · Cited by 58
IgG-induced Ca2+ oscillations in differentiated U937 cells; a study using laser scanning confocal microscopy and co-loaded Fluo-3 and Fura-Red fluorescent probes
Floto, R. A., Mahaut‐Smith, M. P., Somasundaram, B., & Allen, J. M. (1995) · Cell Calcium · doi:10.1016/0143-4160(95)90053-5 · Cited by 58
Activated Macrophage Conditioned Medium: Identification of the Soluble Factors Inducing Cytotoxicity and the L-Arginine Dependent Effector Mechanism
Amber, I. J., Hibbs, J. B., Parker, C. J., Johnson, B. B., Taintor, R. R., & Vavrin, Z. (1991) · Journal of Leukocyte Biology · doi:10.1002/jlb.49.6.610 · Cited by 57
Nitric oxide: An ancestral immunocyte effector molecule
Franchini, A., Conte, A., & Ottaviani, E. (1995) · Advances in Neuroimmunology · doi:10.1016/0960-5428(95)00029-1 · Cited by 57
Burn-Induced Nitric Oxide Release in Humans
Gamelli, R. L., George, M., Sharp-Pucci, M., Dries, D. J., & Radisavljevic, Z. (1995) · doi:10.1097/00005373-199511000-00010 · Cited by 56
Glucocorticoids inhibit the induction of nitric oxide synthase and the related cell damage in adenocarcinoma cells
O'Connor, K. J., & Moncada, S. (1991) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/0925-4439(91)90040-g · Cited by 56
Ketamine Activates the l-Arginine/Nitric Oxide/Cyclic Guanosine Monophosphate Pathway to Induce Peripheral Antinociception in Rats
Romero, T. R. L., Galdino, G. S., da Silva, G. C., Resende, L. C., Perez, A. C., Côrtes, S. F., & Duarte, I. D. G. (2011) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e3182285dda · Cited by 55
Effects of nitric oxide and oxidation in vivo and postmortem on meat tenderness
Warner, R. D., Dunshea, F. R., Ponnampalam, E. N., & Cottrell, J. J. (2005) · Meat Science · doi:10.1016/j.meatsci.2005.04.008 · Cited by 57
Physiological importance of nitric oxide.
Collier, J., & Vallance, P. J. (1991) · BMJ · doi:10.1136/bmj.302.6788.1289 · Cited by 55
EDRF modulates renal hemodynamics during unilateral ureteral obstruction in the rat
Chevalier, R. L., Thornhill, B. A., & Gómez, R. A. (1992) · Kidney International · doi:10.1038/ki.1992.301 · Cited by 54
Non-Heme Diiron Model Complexes Can Mediate Direct NO Reduction: Mechanistic Insight into Flavodiiron NO Reductases
Dong, H. T., White, C. J., Zhang, B., Krebs, C., & Lehnert, N. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.8b08567 · Cited by 53
Effect of Heme Oxygenase Inhibitors on Soluble Guanylyl Cyclase Activity
Serfass, L., & Burstyn, J. N. (1998) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1998.0887 · Cited by 53
Increase in the Production of Interleukin‐6, Interleukin‐10, and Interleukin‐12 by Lipopolysaccharide‐Stimulated Peritoneal Macrophages from Women with Endometriosis
Wu, M., Ho, H., Chen, S., Chao, K., Chen, C., & Yang, Y. (1999) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.1999.tb00082.x · Cited by 52
Development of Polyethylene Glycol-Conjugated Poly-S-Nitrosated Serum Albumin, a Novel S-Nitrosothiol for Prolonged Delivery of Nitric Oxide in the Blood Circulation in Vivo
Katsumi, H., Nishikawa, M., Yamashita, F., & Hashida, M. (2005) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.087429 · Cited by 52
Substance P primes the formation of hydrogen peroxide and nitric oxide in human neutrophils
Sterner‐Kock, A., Braun, R. K., van der Vliet, A., Schrenzel, M. D., McDonald, R. J., Kabbur, M. B., Vulliet, P. R., & Hyde, D. M. (1999) · Journal of Leukocyte Biology · doi:10.1002/jlb.65.6.834 · Cited by 52
Stress differentially induces cationic amino acid transporter gene expression
Kakuda, D. K., Finley, K. D., Maruyama, M., & MacLeod, C. L. (1998) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(98)00155-2 · Cited by 52
Characterization of immunosuppressive functions of murine peritoneal macrophages induced with various agents
Tomioka, H., & Saito, H. (1992) · Journal of Leukocyte Biology · doi:10.1002/jlb.51.1.24 · Cited by 52
Measurement of NO and NO Synthase
Weissman, B. A., & Gross, S. S. (1998) · Current Protocols in Neuroscience · doi:10.1002/0471142301.ns0713s05 · Cited by 51
Self-citation
Exploring the redox reactions between heme and tetrahydrobiopterin in the nitric oxide synthases
Stuehr, D. J., Wei, C., Wang, Z., & Hille, R. (2005) · Dalton Transactions · doi:10.1039/b506355h · Cited by 52
Self-citation
Modulation of human t cell responses by nitric oxide and its derivative, s‐nitrosoglutathione
Merryman, P. F., Clancy, R. M., He, X. Y., & Abramson, S. B. (1993) · Arthritis & Rheumatism · doi:10.1002/art.1780361014 · Cited by 50
Tyrosine kinases are involved with the expression of inducible nitric oxide synthase in human articular chondrocytes
Geng, Y., Maier, R., & Lotz, M. (1995) · Journal of Cellular Physiology · doi:10.1002/jcp.1041630315 · Cited by 49
Immune activation of murine RAW264.7 macrophages by sonicated and alkalized paramylon from Euglena gracilis
Guo, Q., Bi, D., Wu, M., Yu, B., Hu, L., Liu, C., Gu, L., Zhu, H., Lei, A., Xu, X., et al. (2020) · BMC Microbiology · doi:10.1186/s12866-020-01782-y · Cited by 48
Nitric oxide is inactivated by the bacterial pigment pyocyanin.
Warren, J. B., Loi, R., Rendell, N. B., & Taylor, G. W. (1990) · Europe PMC (PubMed Central) · Cited by 48
Activated macrophages depress the contractility of rabbit carotids via an L-arginine/nitric oxide-dependent effector mechanism. Connection with amplified cytokine release.
Bernard, C., Szekely, B., Philip, I., Wollman, E. E., Payen, D. M., & Tedgui, A. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115664 · Cited by 48
Kupffer Cell Cytotoxicity to Hepatocytes in Coculture Requires L-Arginine
Billiar, T. R. (1989) · Archives of Surgery · doi:10.1001/archsurg.1989.01410120062013 · Cited by 48
INHIBITION OF ENDOTHELIAL NITRIC OXIDE BIOSYNTHESIS BY N‐NITRO‐l‐ARGININE
Dubbin, P. N., Zambetis, M., & Dusting, G. J. (1990) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.1990.tb01321.x · Cited by 48
Alleviating Effects of Si-Ni-San, a Traditional Chinese Prescription, on Experimental Liver Injury and Its Mechanisms
Jiang, J., Zhou, C., & Xu, Q. (2003) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.26.1089 · Cited by 47

Authors: Stuehr, D. J., Gross, S. S., Sakuma, I., Levi, R., & Nathan, C. F.
Affiliations: Cornell University (US)
ORCID: Stuehr, D J
Gross, S S
Sakuma, I
Levi, R
Nathan, C F
Venue: The Journal of experimental medicine
Publisher: Rockefeller University Press
Published: 1989-03-01
Volume: 169
Issue: 3
Pages: 1011-1020
ISSN: 0022-1007 (ISSN-L)
1540-9538
DOI: 10.1084/jem.169.3.1011
PMC: PMC2189276
OpenAlex: W1975644913
Cited by: 457
References: 35
Citations by year: 2026: 1 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 6 · 2020: 5 · 2019: 4 · 2018: 5 · 2017: 2 · 2016: 6 · 2015: 8 · 2014: 9 · 2013: 10 · 2012: 4
FWCI: 30.53
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: The Journal of Experimental Medicine (publishedVersion)
PubMed Central (publishedVersion, cc-by-nc-sa)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Heart, Lung, and Blood Institute (HL37407, HL-34215)
National Cancer Institute (CA-43610)
Topics: Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Keywords: macrophages, nitric oxide, arginine metabolism, endothelium-derived relaxing factor, nitrite, nitrate, vasorelaxation, myoglobin, interferon-gamma, LPS, macrophage activation, reactive nitrogen species, macrophage cytotoxicity
MeSH terms: Animals, Aorta, Arginine, Biological Assay, Biological Factors, Chemistry, Endothelium, Vascular, Ferredoxins, Macrophage Activation, Macrophages, Mice, Inbred C3H, Muscle Relaxation, Muscle, Smooth, Vascular, Nitrates, Nitric Oxide, Nitrites, Nitrogen Dioxide, Rabbits, Spectrophotometry, Mice, Chemical Phenomena

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Activated murine macrophages secrete a metabolite of arginine with the bioactivity of endothelium-derived relaxing factor and the chemical reactivity of nitric oxide

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