Cited by 457Nitric Oxide and Endothelin EffectsImmune cells in cancerNeutrophil, Myeloperoxidase and Oxidative Mechanisms

The DOI matches its Crossref record; 34 of the 35 references it cites were found in a registry or an index.

Activated murine macrophages secrete a metabolite of arginine with the bioactivity of endothelium-derived relaxing factor and the chemical reactivity of nitric oxide

Open access

Stuehr, D J, Gross, S S, Sakuma, I, Levi, R, Nathan, C F·1989·The Journal of experimental medicine

DOI 10.1084/jem.169.3.1011PMC PMC2189276

Open this paper in CoChat — free account Open PDF

Abstract

L-arginine-dependent synthesis of nitrite (NO2-) and nitrate (NO3-) by macrophages correlates with and is required for their execution of nonspecific cytotoxicity toward some tumor cells and microbes. However, the bioactive L-arginine metabolites responsible for cytotoxicity are unknown. Mammalian endothelial cells have recently been shown to release nitric oxide (NO.); we therefore determined if this reactive metabolite was synthesized by activated murine macrophages. Macrophage-derived NO. was detected by two independent methods: a bioassay for NO.-mediated relaxation of preconstricted rings of rabbit aorta; and a spectroscopic measurement of the reaction of NO. with clostridial ferredoxin, an Fe-S protein. After activation with IFN-gamma and LPS, macrophages continuously secreted a substance that relaxed rabbit aortic rings denuded of endothelium. Production of the vasorelaxant was enhanced by 0.5 mM L-arginine and inhibited reversibly by NG-methylated L-arginine analogs that block macrophage NO2-/NO3- synthesis. The vasorelaxant was scavenged by ferrous myoglobin, was labile, and was neither NO2- nor a cyclooxygenase metabolite. Activated M phi also secreted a substance that bleached Fd, a reaction carried out by NO. and NO2, but not NO2-. Macrophage bleaching of Fd correlated directly with time, cell number, and concomitant NO2-/NO3- production, required L-arginine, and was independent of reactive oxygen intermediates. Thus, activated murine M phi release NO. and/or a closely related, highly reactive nitrogen oxide such as NO2, during their conversion of L-arginine to NO2-/NO3-. NO. and NO2 may mediate L-arginine-dependent pathologic effects of M phi, as well as physiologic effects not previously considered for this widely distributed cell type.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1084/jem.169.3.1011

Cites

34 of 34 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
Palmer, R. M. J., Ferrige, A. G., & Moncada, S. (1987) · Nature · doi:10.1038/327524a0 · Cited by 10,704
Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.
Ignarro, L. J., Buga, G. M., Wood, K. S., Byrns, R. E., & Chaudhuri, G. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.24.9265 · Cited by 5,074
Vascular endothelial cells synthesize nitric oxide from L-arginine
Palmer, R. M. J., Ashton, D., & Moncada, S. (1988) · Nature · doi:10.1038/333664a0 · Cited by 4,786
Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production.
Ding, A. H., Nathan, C., & Stuehr, D. J. (1988) · The Journal of Immunology · doi:10.4049/jimmunol.141.7.2407 · Cited by 2,840
Self-citation
Macrophage cytotoxicity: role for L-arginine deiminase and imino nitrogen oxidation to nitrite
Hibbs, J. B., Taintor, R. R., & Vavrin, Z. (1987) · Science · doi:10.1126/science.2432665 · Cited by 1,527
L-arginine is the physiological precursor for the formation of nitric oxide in endothelium-dependent relaxation
Palmer, R. M. J., Rees, D. D., Ashton, D. S., & Moncada, S. (1988) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(88)81362-7 · Cited by 1,348
Selective blockade of endothelium-dependent and glyceryl trinitrate-induced relaxation by hemoglobin and by methylene blue in the rabbit aorta.
Martin, W., Villani, G. M., Jothianandan, D., & Furchgott, R. F. (1985) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)20898-9 · Cited by 1,259
Mammalian nitrate biosynthesis: mouse macrophages produce nitrite and nitrate in response to Escherichia coli lipopolysaccharide.
Stuehr, D. J., & Marletta, M. A. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.22.7738 · Cited by 1,126
Self-citation
L-arginine is required for expression of the activated macrophage effector mechanism causing selective metabolic inhibition in target cells.
Hibbs, J. B., Vavrin, Z., & Taintor, R. R. (1987) · The Journal of Immunology · doi:10.4049/jimmunol.138.2.550 · Cited by 938
The Role of Endothelium in the Responses of Vascular Smooth Muscle to Drugs
Furchgott, R. F. (1984) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.24.040184.001135 · Cited by 937

Flagged first, then by citations

Show all 35 references

1 of the 35 references couldn’t be matched to a known paper.

Sorted by citations

Items 201–300 of 457

Macrophage migration inhibitory factor is a neuroendocrine mediator of endotoxaemia
Bernhagen, J., Calandra, T., Cerami, A., & Bucala, R. (1994) · Trends in Microbiology · doi:10.1016/0966-842x(94)90111-h · Cited by 46
Macrophage tumoricidal mechanisms
Klostergaard, J. (1993) · Research in Immunology · doi:10.1016/0923-2494(93)80106-9 · Cited by 46
Nutrient modulation of inflammatory and immune function
Cerra, F. B. (1991) · The American Journal of Surgery · doi:10.1016/0002-9610(91)91136-7 · Cited by 46
Regulation of CAT: Cationic amino acid transporter gene expression
MacLeod, C. L., & Kakuda, D. K. (1996) · Amino Acids · doi:10.1007/bf00813859 · Cited by 45
IL-5 Induces Proliferation and Activation of Microglia via an Unknown Receptor
Liva, S. M., & de Vellis, J. (2001) · Neurochemical Research · doi:10.1023/a:1010983119125 · Cited by 44
Nitric Oxide Mediates the Toxoplasmastatic Activity of Murine Microglial Cellsin vitro
Jun, C., Kim, S. H., Soh, C. T., Kang, S. S., & Chung, H. T. (1993) · Immunological Investigations · doi:10.3109/08820139309084178 · Cited by 44
Nitric Oxide 9 Years On
Bhagat, K., & Vallance, P. J. (1996) · Journal of the Royal Society of Medicine · doi:10.1177/014107689608901204 · Cited by 44
The Role of Cytokines in Experimental Listeriosis
Mielke, M. E. A., Ehlers, S., & Hahn, H. H. (1993) · Immunobiology · doi:10.1016/s0171-2985(11)80363-3 · Cited by 44
Consumption of Eicosapentaenoic Acid and Docosahexaenoic Acid Impair Murine Interleukin‐12 and Interferon‐γ Production In Vivo
Fritsche, K. L., Anderson, M., & Feng, C. (2000) · The Journal of Infectious Diseases · doi:10.1086/315925 · Cited by 43
Preliminary Communication: Possible Role of Reactive Nitrogen Intermediates in Leucocyte‐Mediated Sperm Dysfunction
TOMLINSON, M. J., East, S. J., Barratt, C. L. R., Bolton, A. E., & Cooke, I. D. (1992) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.1992.tb00730.x · Cited by 43
Molecular Characterization of Nitric Oxide Synthase
Bredt, D. S. (1995) · Elsevier eBooks · doi:10.1016/b978-012721985-1/50003-4 · Cited by 43
Endothelial NOS‐deficient mice reveal dual roles for nitric oxide during experimental autoimmune encephalomyelitis
Wu, M., & Tsirka, S. E. (2009) · Glia · doi:10.1002/glia.20842 · Cited by 42
Nitric oxide production by high molecular weight water-soluble chitosan via nuclear factor-κB activation
Jeong, H., Koo, H., Oh, E.-Y., Chae, H., Kim, H., Suh, S.-B., Kim, C., Cho, K. H., Park, B. R., Park, S., et al. (2000) · International Journal of Immunopharmacology · doi:10.1016/s0192-0561(00)00055-2 · Cited by 42
Effect of L-NAME, an Inhibitor of Nitric Oxide Synthesis, on Cardiopulmonary Function in Human Septic Shock
Avontuur, J. A. M., Nolthenius, R. P. T., Buijk, S. L. C. E., Kanhai, K. J. K., & Braining, H. A. (1998) · CHEST Journal · doi:10.1378/chest.113.6.1640 · Cited by 42
Gastric nitric oxide synthase expression during endotoxemia: Implications in mucosal defense in rats
Helmer, K. S., West, S. D., Chang, L. K., Cui, Y., Mercer, D., Shipley, G. L., & Mailman, D. S. (2002) · Gastroenterology · doi:10.1053/gast.2002.34178 · Cited by 42
α2-Macroglobulin Functions as a Cytokine Carrier to Induce Nitric Oxide Synthesis and Cause Nitric Oxide-dependent Cytotoxicity in the RAW 264.7 Macrophage Cell Line
Lysiak, J. J., Hussaini, I. M., Webb, D. J., Glass, W. F., Allietta, M. M., & Gonias, S. L. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.37.21919 · Cited by 42
Neutrophils and mononuclear cells from patients with chronic granulomatous disease release nitric oxide.
Condino‐Neto, A., Muscará, M. N., Grumach, A. S., Carneiro-Sampaio, M. M. S., & Nucci, G. D. (1993) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1993.tb04174.x · Cited by 41
Abilities of activated macrophages to manifest tumoricidal activity and to generate reactive nitrogen intermediates: A comparative study in vitro and ex vivo
Keller, R., & Keist, R. (1989) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(89)91764-6 · Cited by 41
FMN fluorescence in inducible NOS constructs reveals a series of conformational states involved in the reductase catalytic cycle
Ghosh, D. K., Ray, K., Rogers, A. J., Nahm, N. J., & Salerno, J. C. (2012) · FEBS Journal · doi:10.1111/j.1742-4658.2012.08525.x · Cited by 40
Role of nitric oxide in immunological liver damage in mice
Wang, G., & Liu, G.-T. (1995) · Biochemical Pharmacology · doi:10.1016/0006-2952(95)00061-4 · Cited by 40
Important role of the nucleotide excision repair pathway in Mycobacterium smegmatis in conferring protection against commonly encountered DNA-damaging agents
Kurthkoti, K., Kumar, P., Jain, R., & Varshney, U. (2008) · Microbiology · doi:10.1099/mic.0.2008/019638-0 · Cited by 42
Helminth Coinfection Does Not Affect Therapeutic Effect of a DNA Vaccine in Mice Harboring Tuberculosis
Frantz, F. G., Rosada, R. S., Peres‐Buzalaf, C., Perusso, F. R. T., Rodrigues, V., Ramos, S. G., Kunkel, S. L., Silva, C. L., & Faccioli, L. H. (2010) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0000700 · Cited by 38
Activation of Non-Heme Iron-Nitrosyl Complexes: Turning Up the Heat
Lehnert, N., Fujisawa, K., Camarena, S., Dong, H. T., & White, C. J. (2019) · ACS Catalysis · doi:10.1021/acscatal.9b03219 · Cited by 38
Nitric Oxide Synthase Isoforms Undertake Unique Roles During Excitotoxicity
Parathath, S. R., Gravanis, I., & Tsirka, S. E. (2007) · Stroke · doi:10.1161/strokeaha.106.478826 · Cited by 38
Myocardial ischemia and infarction: growth of ideas
Bing, R. (2001) · Cardiovascular Research · doi:10.1016/s0008-6363(01)00250-4 · Cited by 38
Sensitivity of Bacteria to NaNO2 and to L‐Arginine‐Dependent System in Murine Macrophages
Saito, S., Onozuka, K., Shinomiya, H., & Nakano, M. (1991) · Microbiology and Immunology · doi:10.1111/j.1348-0421.1991.tb01561.x · Cited by 37
Localization of cyclic GMP-dependent protein kinase in human mononuclear phagocytes
Pryzwansky, K. B., Kidao, S., Wyatt, T. A., Reed, W., & Lincoln, T. M. (1995) · Journal of Leukocyte Biology · doi:10.1002/jlb.57.4.670 · Cited by 37
Feedback suppression of staphylococcal enterotoxin-stimulated T-lymphocyte proliferation by macrophages through inductive nitric oxide synthesis
Isobe, K., & Nakashima, I. (1992) · Infection and Immunity · doi:10.1128/iai.60.11.4832-4837.1992 · Cited by 37
Interferon‐γ/lipolysaccharide‐treated mouse embryonic fibroblasts are killed by a glycolysis/ l ‐arginine‐dependent process accompanied by depression of mitochondrial respiration
Dijkmans, R., & Billiau, A. (1991) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1991.tb16356.x · Cited by 36
Unraveling the S ‐nitrosoproteome: Tools and strategies
López‐Sánchez, L. M., Muntané, J., de la Mata, M., & Rodríguez‐Ariza, A. (2009) · PROTEOMICS · doi:10.1002/pmic.200800546 · Cited by 35
IL-17A Promotes Intracellular Growth of Mycobacterium by Inhibiting Apoptosis of Infected Macrophages
Cruz, A., Ludovico, P., Torrado, E., Gama, J. B., Sousa, J., Gaifem, J., Appelberg, R., Rodrigues, F. J. S., Cooper, A. M., Pedrosa, J., et al. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00498 · Cited by 35
Immunohistochemical localization of peptidylarginine deiminase in the rat brain
Vincent, S. R., Leung, E., & Watanabe, K. (1992) · Journal of Chemical Neuroanatomy · doi:10.1016/0891-0618(92)90041-n · Cited by 35
Glutathione S-transferase and MRP1 form an integrated system involved in the storage and transport of dinitrosyl–dithiolato iron complexes in cells
Lok, H. C., Sahni, S., Richardson, V., Kalinowski, D. S., Kovačević, Ž., Lane, D. J. R., & Richardson, D. R. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.07.002 · Cited by 34
A nanoparticle delivery vehicle for S-nitroso-N-acetyl cysteine: Sustained vascular response
Nacharaju, P., Tuckman-Vernon, C., Maier, K. E., Chouake, J. S., Friedman, A., Cabrales, P., & Friedman, J. M. (2012) · Nitric Oxide · doi:10.1016/j.niox.2012.06.003 · Cited by 35
[15] Determination and regulation of nitric oxide production from macrophages by lipopolysaccharides, cytokines, and retinoids
Aggarwal, B. B., & Mehta, K. (1996) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(96)69018-1 · Cited by 34
Developing iron nitrosyl complexes as NO donor prodrugs
Dillinger, S. A. T., Schmalle, H. W., Fox, T., & Berke, H. (2007) · Dalton Transactions · doi:10.1039/b702461d · Cited by 33
Chapter 6 Role of nitric oxide in temperature regulation
SCHMID, H. A., Riedel, W., & Simon, E. (1998) · Progress in brain research · doi:10.1016/s0079-6123(08)62031-2 · Cited by 32
The role of nitric oxide in lipoxin A4‐induced polymorphonuclear neutrophil‐dependent cytotoxicity to human vascular endothelium in vitro
Bratt, J., & Gyllenhammar, H. (1995) · Arthritis & Rheumatism · doi:10.1002/art.1780380609 · Cited by 33
Epinephrine, DNA integrity and oxidative stress in workers exposed to extremely low-frequency electromagnetic fields (ELF-EMFs) at 132 kV substations
Tiwari, R. K., Lakshmi, N. K., Bhargava, S. C., & Ahuja, Y. R. (2014) · Electromagnetic Biology and Medicine · doi:10.3109/15368378.2013.869755 · Cited by 32
Alteration of S‐nitrosothiol homeostasis and targets for protein S‐nitrosation in human hepatocytes
Lopez-Sanchez, L. M., Corrales, F. J., González, R., Ferrín, G., Muñoz-Castañeda, J. R., Ranchal, I., Hidalgo, A. B., Briceño, J., López‐Cillero, P., Gómez‐Bravo, M. Á., et al. (2008) · PROTEOMICS · doi:10.1002/pmic.200700313 · Cited by 32
Nitric oxide synthase responsible for l ‐arginine‐induced relaxation of rat aortic rings in vitro may be an inducible type
Moritoki, H., Takeuchi, S., Hisayama, T., & Kondoh, W. (1992) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1992.tb12752.x · Cited by 32
l ‐Arginine and arginine analogues: effects on isolated blood vessels and cultured endothelial cells
Schmidt, H. H. H. W., Baeblich, S. E., Zernikow, B. C., Klein, M. M., & Böhme, E. (1990) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1990.tb12104.x · Cited by 32
The NO-responsive hemoglobins of Campylobacter jejuni: Concerted responses of two globins to NO and evidence in vitro for globin regulation by the transcription factor NssR
Smith, H. K., Shepherd, M., Monk, C. E., Green, J. D., & Poole, R. K. (2011) · Nitric Oxide · doi:10.1016/j.niox.2010.12.009 · Cited by 31
Effects of Toll-like receptor ligands on RAW 264.7 macrophage morphology and zymosan phagocytosis
Sigola, L. B., Fuentes, A.-L., Millis, L., Vapenik, J., & Murira, A. (2016) · Tissue and Cell · doi:10.1016/j.tice.2016.04.002 · Cited by 31
Adherence status regulates the primary cellular activation responses to the flavivirus West Nile.
Shen, J., Devery, J. M., & King, N. J. C. (1995) · PubMed Central · Cited by 31
The bioactivity of neuronal-derived nitric oxide in aging and neurodegeneration: Switching signaling to degeneration
Ledo, A., Lourenço, C. F., Cadenas, E., Barbosa, R. M., & Laranjinha, J. A. N. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.11.005 · Cited by 30
Photoinduced Nitric Oxide Release from a Nitrobenzene Derivative in Mitochondria
Horinouchi, T., Nakagawa, H., Suzuki, T., Fukuhara, K., & Miyata, N. (2011) · Chemistry - A European Journal · doi:10.1002/chem.201001967 · Cited by 30
Nitric Oxide as a Communication Signal in Vascular and Neuronal Cells
Ignarro, L. J. (1996) · Elsevier eBooks · doi:10.1016/b978-012435555-2/50004-8 · Cited by 30
Vascular responsiveness to nitric oxide synthesis inhibition in hypertensive rats.
Pucci, M. L., Miller, K. B., Dick, L. B., Guan, H., Lin, L., & Nasjletti, A. (1994) · Hypertension · doi:10.1161/01.hyp.23.6.744 · Cited by 30
Expression of TGF-βs and their receptors is differentially modulated by reactive oxygen species and nitric oxide in human articular chondrocytes
Ayache, N., Boumédiene, K., Mathy-Hartert, M., Reginster, J., Henrotin, Y. E., & Pujol, J. ‐. (2002) · Osteoarthritis and Cartilage · doi:10.1053/joca.2001.0499 · Cited by 29
Endothelium‐derived relaxing factor (EDRF) and nitric oxide (NO). I. Physiology, pharmacology and pathophysiological implications
Feng, Q., & Hedner, T. (1990) · Clinical Physiology · doi:10.1111/j.1475-097x.1990.tb00822.x · Cited by 29
Acid-induced nitrite reduction of nonheme iron( ii )-nitrite: mimicking biological Fe–NiR reactions
kulbir, K., Das, S. K., Devi, T., Ghosh, S., Sahoo, S. C., & Kumar, P. (2023) · Chemical Science · doi:10.1039/d2sc06704h · Cited by 30
Simple Fabrication of Amperometric Nitric Oxide Microsensors Based on Electropolymerized Membrane Films
Shim, J. H., Do, H., & Lee, Y.-M. (2009) · Electroanalysis · doi:10.1002/elan.200900353 · Cited by 28
Modulation of the conformational state of mitochondrial complex I as a target for therapeutic intervention
Galkin, A. S., & Moncada, S. (2017) · Interface Focus · doi:10.1098/rsfs.2016.0104 · Cited by 30
Role of the nitric oxide synthase pathway in inhibition of growth of interferon-sensitive and interferon-resistant Rickettsia prowazekii strains in L929 cells treated with tumor necrosis factor alpha and gamma interferon
Turco, J., & Winkler, H. H. (1993) · Infection and Immunity · doi:10.1128/iai.61.10.4317-4325.1993 · Cited by 28
Endothelium-Derived Relaxing Factor
Cooke, J. P., & Tsao, P. S. (1996) · Humana Press eBooks · doi:10.1007/978-1-4612-0231-8_1 · Cited by 27
Co-localization of NADPH diaphorase reactivity and vasoactive intestinal polypeptide in human colon
Keränen, U., Vanhatalo, S., Kiviluoto, T. A., Kivilaakso, E. O., & Soinila, S. O. (1995) · Journal of the Autonomic Nervous System · doi:10.1016/0165-1838(95)00010-u · Cited by 26
Nitric oxide derived from L-arginine impairs cytoplasmic pH regulation by vacuolar-type H+ ATPases in peritoneal macrophages.
Swallow, C. J., Grinstein, S., Sudsbury, R. A., & Rotstein, O. D. (1991) · The Journal of Experimental Medicine · doi:10.1084/jem.174.5.1009 · Cited by 26
Revisiting Nitric Oxide Signaling: Where Was It, and Where Is It Going?
Marletta, M. A. (2021) · Biochemistry · doi:10.1021/acs.biochem.1c00276 · Cited by 25
Interaction of IFN α/β with host cells essential to the early inhibition of friend erythroleukemia visceral metastases in mice
Gresser, I., Kaido, T. J., Maury, C., Woodrow, D. F., Moss, J., & Belardelli, F. (1994) · International Journal of Cancer · doi:10.1002/ijc.2910570427 · Cited by 25
Induction of nitric oxide synthase activity in phagocytic cells inhibited by tricyclodecan‐9‐yl‐xanthogenate (D609)
Tschaikowsky, K., Meisner, M., Schönhuber, F., & Rügheimer, E. (1994) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1994.tb17043.x · Cited by 25
MDP and LPS act synergistically to induce arginine-dependent cytostatic activity in rat alveolar macrophages
BARRATT, G. M., Raddassi, K., Petit, J. F., & Tenu, J. (1991) · International Journal of Immunopharmacology · doi:10.1016/0192-0561(91)90094-n · Cited by 25
Endrin-induced production of nitric oxide by rat peritoneal macrophages
Akubue, P. I., & Stohs, S. J. (1992) · Toxicology Letters · doi:10.1016/0378-4274(92)90035-i · Cited by 25
Cyclosporin A protects pancreatic islet cells from nitric oxide‐dependent macrophage cytotoxicity
Burkart, V., Imai, Y., Kallmann, B. A., & Kolb, H. (1992) · FEBS Letters · doi:10.1016/0014-5793(92)81183-m · Cited by 25
Gene expression profiles of NO- and HNO-donor treated breast cancer cells: insights into tumor response and resistance pathways
Cheng, R. Y. S., Basudhar, D., Ridnour, L. A., Heinecke, J. L., Kesarwala, A. H., Glynn, S. A., Switzer, C., Ambs, S., Miranda, K. M., & Wink, D. A. (2014) · Nitric Oxide · doi:10.1016/j.niox.2014.08.003 · Cited by 25
Relaxation of distal colonic circular smooth muscle by nitric oxide derived from human leucocytes.
Middleton, S. J., Shorthouse, M., & Hunter, J. O. (1993) · Gut · doi:10.1136/gut.34.6.814 · Cited by 24
Alkaline buffers release EDRF from bovine cultured aortic endothelial cells
Mitchell, J. A., Nucci, G. D., Warner, T. D., & Vane, J. R. (1991) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1991.tb09783.x · Cited by 24
Docosahexaenoic Acid, a Component of Fish Oil, Inhibits Nitric Oxide Productionin Vitro
Jeyarajah, D. R., Kielar, M. L., Penfield, J. G., & Lu, C. Y. (1999) · Journal of Surgical Research · doi:10.1006/jsre.1999.5586 · Cited by 24
The Fe2(NO)2 Diamond Core: A Unique Structural Motif In Non‐Heme Iron–NO Chemistry
Dong, H. T., Speelman, A. L., Kozemchak, C. E., Sil, D., Krebs, C., & Lehnert, N. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201911968 · Cited by 23
PURIFICATION AND CHARACTERIZATION OF IRON SUPEROXIDE DISMUTASE AND COPPER–ZINC SUPEROXIDE DISMUTASE FROMACANTHAMOEBA CASTELLANII
Choi, D., Na, B., Seo, M.-S., Song, H.-R., & Song, C. (2000) · Journal of Parasitology · doi:10.1645/0022-3395(2000)086[0899:pacois]2.0.co;2 · Cited by 23
Space, time and nitric oxide – neuronal nitric oxide synthase generates signal pulses
Salerno, J. C., & Ghosh, D. K. (2009) · The FEBS Journal · doi:10.1111/j.1742-4658.2009.07382.x · Cited by 21
Human Serum Albumin as Carrier in Drug Delivery Systems
Ishima, Y., & Maruyama, T. (2015) · YAKUGAKU ZASSHI · doi:10.1248/yakushi.15-00227-1 · Cited by 22
Nitric Oxide: Physiological Roles, Biosynthesis and Medical Uses
Adams, D. R., Brochwicz‐Lewinski, M., & BUTLER, A. R. (1999) · Fortschritte der Chemie Organischer Naturstoffe/Fortschritte der Chemie organischer Naturstoffe/Progress in the chemistry of organic natural products · doi:10.1007/978-3-7091-6351-1_1 · Cited by 23
INACTIVATION OF CEREBELLAR NITRIC OXIDE SYNTHASE BY ETHANOL IN VITRO
Fataccioli, V., Gentil, M., Nordmann, R., & Rouach, H. (1997) · Alcohol and Alcoholism · doi:10.1093/oxfordjournals.alcalc.a008318 · Cited by 22
Docosahexaenoic acid, a constituent of fetal and neonatal serum, inhibits nitric oxide production by murine macrophages stimulated by IFNγ plus LPS, or by IFNγ plus Listeria monocytogenes
Lu, C. Y., Penfield, J. G., Khair‐El‐Din, T. A., Sicher, S. C., Kielar, M. L., Vázquez, M. A., & Che, L. (1998) · Journal of Reproductive Immunology · doi:10.1016/s0165-0378(98)00005-9 · Cited by 22
The role of nitric oxide generation in interferon-evoked cytochrome P450 down-regulation
Hodgson, P. D., & Renton, K. W. (1995) · International Journal of Immunopharmacology · doi:10.1016/0192-0561(95)00083-6 · Cited by 22
Role of nutrition in the management of malnutrition and immune dysfunction of trauma.
Cerra, F. B. (1992) · Journal of the American College of Nutrition · doi:10.1080/07315724.1992.10718255 · Cited by 22
Hemodynamic and Cardiovascular Effects of Nitric Oxide Modulation in the Therapy of Septic Shock
Schoonover, L. L., Stewart, A. S., & Clifton, G. D. (2000) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1592/phco.20.15.1184.34587 · Cited by 21
Suppression ofPlasmodium chabaudiParasitemia Is Independent of the Action of Reactive Oxygen Intermediates and/or Nitric Oxide
Gillman, B. M., Batchelder, J. M., Flaherty, P. R., & Weidanz, W. P. (2004) · Infection and Immunity · doi:10.1128/iai.72.11.6359-6366.2004 · Cited by 21
Calcium- and Protein Kinase C–Dependent Basal Tone in the Aorta of Hypertensive Rats
Pucci, M. L., Tong, X., Miller, K. B., Guan, H., & Nasjletti, A. (1995) · Hypertension · doi:10.1161/01.hyp.25.4.752 · Cited by 21
What Is the Right Level of Activation of a High-Spin {FeNO}7 Complex to Enable Direct N–N Coupling? Mechanistic Insight into Flavodiiron NO Reductases
Dong, H. T., Camarena, S., Sil, D., Lengel, M. O., Zhao, J. Y., Hu, M. Y., Alp, E. E., Krebs, C., & Lehnert, N. (2022) · Journal of the American Chemical Society · doi:10.1021/jacs.2c04292 · Cited by 20
Dissecting regulation mechanism of the FMN to heme interdomain electron transfer in nitric oxide synthases
Feng, C., Chen, L., Li, W., Elmore, B. O., Fan, W., & Sun, X. (2013) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2013.09.005 · Cited by 25
Altered protein expression and protein nitration pattern during d ‐galactosamine‐induced cell death in human hepatocytes: a proteomic analysis
Rodríguez‐Ariza, A., Lopez-Sanchez, L. M., González, R., Corrales, F. J., López, P., Bernardos, A., & Muntané, J. (2005) · Liver International · doi:10.1111/j.1478-3231.2005.01172.x · Cited by 20
Reduced Photoreceptor Damage after Photodynamic Therapy through Blockade of Nitric Oxide Synthase in a Model of Choroidal Neovascularization
She, H., Nakazawa, T., Matsubara, A., Hisatomi, T., Young, T. A., Michaud, N. A., Connolly, E. J., Hafezi‐Moghadam, A., Gragoudas, E. S., & Miller, J. W. (2007) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.06-0979 · Cited by 20
PHENOTYPE AND LOCALIZATION OF MACROPHAGES EXPRESSING INDUCIBLE NITRIC OXIDE SYNTHASE IN RAT HEPATIC ALLOGRAFT REJECTION
Goto, M., Yamaguchi, Y., Ichiguchi, O., Miyanari, N., Akizuki, E., Matsumura, F., Matsuda, T., Mori, K., & Ogawa, M. (1997) · Transplantation · doi:10.1097/00007890-199707270-00022 · Cited by 20
Chemiluminescence quantification of NO and its derivatives in liquid samples
Laver, J. R., Stevanin, T. M., & Read, R. C. (2008) · Methods in Enzymology · doi:10.1016/s0076-6879(08)36007-8 · Cited by 19
Suppression of PTRF Alleviates the Polymicrobial Sepsis Induced by Cecal Ligation and Puncture in Mice
Zheng, Y., Lee, S., Liang, X., Wei, S., Moon, H., & Jin, Y. (2013) · The Journal of Infectious Diseases · doi:10.1093/infdis/jit364 · Cited by 19
Evaluation of oxidative stress and DNA damage in traffic policemen exposed to vehicle exhaust
Badabagni, S. P., Peddireddy, V., Rekhadevi, P. V., Vani, G. T., Varre, S., Rani, P. U., Grover, P., Mundluru, H. P., & Penagaluru, P. R. (2013) · Biomarkers · doi:10.3109/1354750x.2013.801517 · Cited by 19
Lipopolysaccharide (LPS) Stimulates the Production of Tumor Necrosis Factor (TNF)‐α and Expression of Inducible Nitric Oxide Synthase (iNOS) by Osteoclasts (OCL) in Murine Bone Marrow Cell Culture
Kikkawa, I., Saito, S., Tominaga, K., Hoshino, Y. Y., Ooi, Y., & Nakano, M. (1998) · Microbiology and Immunology · doi:10.1111/j.1348-0421.1998.tb02329.x · Cited by 19
Physicochemical, tissue distribution, and vasodilation characteristics of nitrosated serum albumin: delivery of nitric oxide in vivo
Katsumi, H., Nishikawa, M., Ma, S.-F., Yamashita, F., & Hashida, M. (2004) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.20147 · Cited by 19
Nitric Oxide Inhibits INFγ-induced Increases in CIITA mRNA Abundance and Activation of CIITA Dependent Genes—Class II MHC, Ii and H-2M
Kielar, M. L., Sicher, S. C., Penfield, J. G., Jeyarajah, D. R., & Lu, C. Y. (2000) · Inflammation · doi:10.1023/a:1007012128392 · Cited by 19
Nitric Oxide Synthase mRNA in Endothelial Cells: Synergistic Induction by Interferon-γ, Tumor Necrosis Factor-α and Lipopolysaccharide and Inhibition by Dexamethasone
Marumo, T., Nakaki, T., Adachi, H., Esumi, H., Suzuki, H., Saruta, T., & Kato, R. (1993) · The Japanese Journal of Pharmacology · doi:10.1254/jjp.63.327 · Cited by 19
Sepsis and Nitric Oxide
Avontuur, J. A. M., Bruining, H. A., & İnce, C. (1996) · Advances in experimental medicine and biology · doi:10.1007/978-1-4613-0333-6_71 · Cited by 19
Development and characterization of two porcine monocyte-derived macrophage cell lines
Chitko-McKown, C. G., Chapes, S. K., Miller, L. C., Riggs, P. K., Ortega, M. T., Green, B. T., & McKown, R. D. (2013) · Results in Immunology · doi:10.1016/j.rinim.2013.03.001 · Cited by 18
Immunomodulation by Mycoplasmas: Artifacts, Facts and Active Molecules
Mühlradt, P. F. (2002) · Springer eBooks · doi:10.1007/0-306-47606-1_20 · Cited by 18
Inhibition of Macrophage Nitric‐Oxide Production and Ia‐Expression by Docosahexaenoic Acid, a Constituent of Fetal and Neonatal Serum
Khair‐El‐Din, T. A., Sicher, S. C., Vázquez, M. A., & Lu, C. Y. (1996) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.1996.tb00133.x · Cited by 18
Induction of nitric oxide synthase in rat gastric smooth muscle preparations
Zheng, X., Sharkey, K. A., & Hollenberg, M. D. (1997) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1997.273.5.g1101 · Cited by 18
Serum nitric oxide in children with dengue infection.
Trairatvorakul, P., Chongsrisawat, V., Ngamvasinont, D., Asawarachun, D., Nantasook, J., & Poovorawan, Y. (2005) · PubMed · Cited by 17
Hominis Placenta facilitates hair re-growth by upregulating cellular proliferation and expression of fibroblast growth factor-7
Seo, H.-S., Lee, D., Chung, J.-H., Lee, C. H., Kim, H. R., Kim, J. E., Kim, B. J., Jung, M. H., Ha, K., & Jeong, H.-S. (2016) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-016-1180-3 · Cited by 17
Evaluation of the efficacy and safety of cow placenta extract lotion versus minoxidil 2% in the treatment of female pattern androgenetic alopecia
Barat, T., Abdollahimajd, F., Dadkhahfar, S., & Moravvej, H. (2020) · International Journal of Women’s Dermatology · doi:10.1016/j.ijwd.2020.04.012 · Cited by 17

Authors: Stuehr, D. J., Gross, S. S., Sakuma, I., Levi, R., & Nathan, C. F.
Affiliations: Cornell University (US)
ORCID: Stuehr, D J
Gross, S S
Sakuma, I
Levi, R
Nathan, C F
Venue: The Journal of experimental medicine
Publisher: Rockefeller University Press
Published: 1989-03-01
Volume: 169
Issue: 3
Pages: 1011-1020
ISSN: 0022-1007 (ISSN-L)
1540-9538
DOI: 10.1084/jem.169.3.1011
PMC: PMC2189276
OpenAlex: W1975644913
Cited by: 457
References: 35
Citations by year: 2026: 1 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 6 · 2020: 5 · 2019: 4 · 2018: 5 · 2017: 2 · 2016: 6 · 2015: 8 · 2014: 9 · 2013: 10 · 2012: 4
FWCI: 30.53
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: The Journal of Experimental Medicine (publishedVersion)
PubMed Central (publishedVersion, cc-by-nc-sa)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Heart, Lung, and Blood Institute (HL37407, HL-34215)
National Cancer Institute (CA-43610)
Topics: Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Keywords: macrophages, nitric oxide, arginine metabolism, endothelium-derived relaxing factor, nitrite, nitrate, vasorelaxation, myoglobin, interferon-gamma, LPS, macrophage activation, reactive nitrogen species, macrophage cytotoxicity
MeSH terms: Animals, Aorta, Arginine, Biological Assay, Biological Factors, Chemistry, Endothelium, Vascular, Ferredoxins, Macrophage Activation, Macrophages, Mice, Inbred C3H, Muscle Relaxation, Muscle, Smooth, Vascular, Nitrates, Nitric Oxide, Nitrites, Nitrogen Dioxide, Rabbits, Spectrophotometry, Mice, Chemical Phenomena

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Activated murine macrophages secrete a metabolite of arginine with the bioactivity of endothelium-derived relaxing factor and the chemical reactivity of nitric oxide

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks