The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Angiogenic factors stimulate mast-cell migration
Abstract
Mast cells accumulate at sites of angiogenesis. The factor(s) that control mast-cell recruitment at these sites have yet to be defined. We sought to determine if angiogenic factors result in mast-cell chemotaxis. In this study, we observed that platelet-derived growth factor-AB (PDGF-AB), vascular endothelial cell growth factor (VEGF), and basic fibroblast growth factor (bFGF) each cause directed migration of murine mast cells at picomolar concentrations, with a typical bell-shaped dose-response curve. Another potent angiogenic factor, platelet-derived endothelial cell growth factor (PD-ECGF), appears to promote chemokinesis of mast cells, whereas tumor necrosis factor-alpha, a weak angiogenic factor, is less robust but still functions as a mast cell chemotactic factor. Epidermal growth factor (EGF), a growth factor with minimal angiogenic properties, was ineffective as a mast cell chemotactic factor. A checkerboard analysis confirmed the directional chemotactic response of PDGF-AB, VEGF, and bFGF, while indicating the chemokinetic response induced by PD-ECGF. Cross-desensitization of growth-factor-induced directed migration was observed between PDGF-AB and bFGF, and also between PDGF-AB and PD-ECGF. Tyrosine kinase-inhibitor genistein effectively dampened the chemotactic responses, whereas pertussis toxin had no effect. In summary, our findings suggest that factors known to act on endothelial cells and stimulate neovascularization may simultaneously serve to recruit mast cells to these sites. The local accumulation of mast cells is believed to facilitate new vessel formation through complex cell:cell interactions.
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Cites
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Cited by
Mast Cells Migrate from Blood to Brain
Silverman, A.-J., Sutherland, A. K., Wilhelm, M., & Silver, R. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-01-00401.2000 · Cited by 228
Norton, L. W., Koschwanez, H. E., Wisniewski, N. A., Klitzman, B., & Reichert, W. M. (2007) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.31088 · Cited by 128
Kim, M.-S., Kim, Y. K., Lee, D. H., Seo, J. E., Cho, K. H., Eun, H. C., & Chung, J. H. (2009) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2008.08838.x · Cited by 71
Metadata
- Authors
- Gruber, B., Marchese, M., & Kew, R.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 1995-10-01
- Volume
- 86
- Issue
- 7
- Pages
- 2488-2493
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W1530655559
- Cited by
- 275
- References
- 25
- FWCI
- 3.88
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
