The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Dexamethasone and pentoxifylline inhibit endotoxin-induced cachectin/tumor necrosis factor synthesis at separate points in the signaling pathway.
Open accessAbstract
The induction of cachectin/tumor necrosis factor (TNF) synthesis by bacterial endotoxins is a process that entails activation at several levels. Cachectin/TNF gene transcription is accelerated, leading to rapid accumulation of mRNA within the macrophage cytosol. In addition, translational derepression occurs, leading to far more efficient message utilization. Through the use of posttranscriptional reporter constructs, we now demonstrate that certain agents capable of inhibiting cachectin/TNF biosynthesis operate through different mechanisms. In RAW 264.7 macrophages, pentoxifylline blocks cachectin/TNF mRNA accumulation but has no effect upon the efficiency of reporter mRNA translation. Dexamethasone, on the other hand, has only a modest effect on cachectin/TNF mRNA accumulation, but strongly impedes translational derepression. Combined application of dexamethasone and pentoxifylline to macrophages causes a greater suppression of cachectin/TNF biosynthesis that can be achieved by either agent alone. These findings suggest that the signaling pathway activated by endotoxin is branched, and that selective inhibition of different parts of the pathway may be achieved through the use of distinct agents.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.
Gorman, C. M., Moffat, L. F., & Howard, B. H. (1982) · Molecular and Cellular Biology · doi:10.1128/mcb.2.9.1044 · Cited by 7,830
Shock and Tissue Injury Induced by Recombinant Human Cachectin
Tracey, K. J., Beutler, B., Lowry, S. F., Merryweather, J., Wolpe, S., Milsark, I. W., Hariri, R. J., Fahey, T. J., Zentella, A., Albert, J. D., et al. (1986) · Science · doi:10.1126/science.3764421 · Cited by 2,549
Self-citationBeutler, B., Milsark, I. W., & Cerami, A. C. (1985) · Science · doi:10.1126/science.3895437 · Cited by 2,352
Self-citationCellular and molecular regulation of tumor necrosis factor-alpha production by pentoxofylline
Strieter, R. M., Remick, D. G., Ward, P. A., Spengler, R. N., Lynch, J. P., Larrick, J., & Kunkel, S. L. (1988) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(88)81271-3 · Cited by 561
Han, J., Brown, T., & Beutler, B. (1990) · The Journal of experimental medicine · doi:10.1084/jem.171.2.465 · Cited by 477
Self-citationCachectin/tumor necrosis factor induces lethal shock and stress hormone responses in the dog.
Tracey, K. J., Lowry, S. F., Fahey, T. J., Albert, J. D., Fong, Y., HESSE, D. G., Beutler, B., Manogue, K. R., Calvano, S. E., & Hu, W. M. (1987) · PubMed · Cited by 429
Self-citationLipoprotein lipase suppression in 3T3-L1 cells by an endotoxin-induced mediator from exudate cells.
Kawakami, M., Pekala, P. H., Lane, M. D., & Cerami, A. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.3.912 · Cited by 267
Cseh, K., & Beutler, B. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)71615-3 · Cited by 71
Self-citation
Cited by
Alcoholic liver disease: mechanisms of injury and targeted treatment
Louvet, A., & Mathurin, P. (2015) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2015.35 · Cited by 855
Pathogenesis of alcoholic liver disease: Role of oxidative metabolism
Ceni, E., Mello, T., & Galli, A. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i47.17756 · Cited by 521
Rock, C. S., & Lowry, S. F. (1991) · Journal of Surgical Research · doi:10.1016/0022-4804(91)90146-d · Cited by 503
Levi, M., ten Cate, H., Bauer, K. A., van der Poll, T., Edgington, T. S., Büller, H. R., van Deventer, S. J., Hack, C. E., ten Cate, J. W., & Rosenberg, R. D. (1994) · Journal of Clinical Investigation · doi:10.1172/jci116934 · Cited by 406
Jin, S.-L. C., & Conti, M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.122041599 · Cited by 367
Metadata
- Authors
- Han, J., Thompson, P., & Beutler, B.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1990-07-01
- Volume
- 172
- Issue
- 1
- Pages
- 391-394
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2151825728
- Cited by
- 508
- References
- 8
- FWCI
- 9.97
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Dexamethasone and pentoxifylline inhibit endotoxin-induced cachectin/tumor necrosis factor synthesis at separate points in the signaling pathway. https://app.cochat.ai/papers/10.1084/jem.172.1.391
- The paper
- Han, J., Thompson, P., & Beutler, B. (1990). Dexamethasone and pentoxifylline inhibit endotoxin-induced cachectin/tumor necrosis factor synthesis at separate points in the signaling pathway. The Journal of experimental medicine. https://doi.org/10.1084/jem.172.1.391
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
