The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Inhibition of endotoxin-induced activation of coagulation and fibrinolysis by pentoxifylline or by a monoclonal anti-tissue factor antibody in chimpanzees.
Open accessAbstract
Knowledge of the pathogenetic mechanisms responsible for the activation of the coagulation system associated with endotoxemia is important for the development of improved modalities for prevention and treatment. We analyzed the appearance in plasma of TNF, IL-6, and indices of coagulation and fibrinolytic system activation in normal chimpanzees after intravenous infusion of endotoxin. Endotoxin infusion elicited reproducible and dose-dependent elevations in serum TNF and IL-6, as well as marked increases in thrombin generation in vivo as measured by immunoassays for prothrombin activation fragment F1 + 2, thrombin-antithrombin III complexes, and fibrinopeptide A. Activation of the fibrinolytic mechanism was monitored with assays for plasminogen activator activity and plasmin-alpha 2-antiplasmin complexes. To potentially intervene in the molecular pathways elicited by endotoxin, pentoxifylline, an agent that interrupts "immediate early" gene activation by monocytes, or a potent monoclonal antibody that neutralizes tissue factor-mediated initiation of coagulation, were infused shortly before endotoxin. Pentoxifylline markedly inhibited increases in the levels of TNF and IL-6, as well as the effects on coagulation and fibrinolysis. In contrast, the monoclonal antibody to tissue factor completely abrogated the augmentation in thrombin generation, but had no effect on cytokine levels or fibrinolysis. We conclude that the endotoxin-induced activation of coagulation appears to be mediated by the tissue factor-dependent pathway, the fibrinolytic response triggered by endotoxin is not dependent on the generation of thrombin, and that the release of cytokines may be important in mediating the activation of both the coagulation and the fibrinolytic mechanisms in vivo.
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Cites
THE PREPARATION OF 131I-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY
GREENWOOD, F., HUNTER, W., & GLOVER, J. (1963) · Biochemical Journal · doi:10.1042/bj0890114 · Cited by 10,152
Detection of circulating tumor necrosis factor after endotoxin administration
Michie, H. R., Manogue, K. R., Spriggs, D. R., Revhaug, A., O'Dwyer, S., Dinarello, C. A., Cerami, A., Wolff, S. M., & Wilmore, D. W. (1988) · New England Journal of Medicine · doi:10.1056/nejm198806093182301 · Cited by 1,677
Modulation of endothelial cell hemostatic properties by tumor necrosis factor.
Nawroth, P. P., & Stern, D. M. (1986) · The Journal of experimental medicine · doi:10.1084/jem.163.3.740 · Cited by 1,311
Bevilacqua, M. P., Pober, J. S., Majeau, G. R., Fiers, W., Cotran, R. S., & Gimbrone, M. A. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.12.4533 · Cited by 1,067
van Deventer, S., Buller, H., ten Cate, J., Aarden, L., Hack, C., & Sturk, A. (1990) · Blood · doi:10.1182/blood.v76.12.2520.2520 · Cited by 851
Self-citationActivation of Coagulation after Administration of Tumor Necrosis Factor to Normal Subjects
van der Poll, T., Büller, H. R., ten Cate, H., Wortel, C. H., Bauer, K. A., van Deventer, S. J. H., Hack, C. E., Sauerwein, H. P., Rosenberg, R. D., & ten Cate, J. W. (1990) · New England Journal of Medicine · doi:10.1056/nejm199006073222302 · Cited by 667
Self-citationSchleef, R. R., Bevilacqua, M. P., Sawdey, M., Gimbrone, M. A., & Loskutoff, D. J. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)60636-2 · Cited by 546
Han, J., Thompson, P., & Beutler, B. (1990) · The Journal of experimental medicine · doi:10.1084/jem.172.1.391 · Cited by 508
Cultured human endothelial cells generate tissue factor in response to endotoxin.
Colucci, M., Balconi, G., Lorenzet, R., Pietra, A., Locati, D., Donati, M. B., & Semeraro, N. (1983) · Journal of Clinical Investigation · doi:10.1172/jci110945 · Cited by 500
Suffredini, A. F., Harpel, P. C., & Parrillo, J. E. (1989) · New England Journal of Medicine · doi:10.1056/nejm198905043201802 · Cited by 476
Cited by
Two-Way Interactions Between Inflammation and Coagulation
Levi, M., & van der Poll, T. (2005) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2005.07.004 · Cited by 334
Self-citationInterleukin-6 Stimulates Coagulation, not Fibrinolysis, in Humans
Stouthard, J. M. L., Levi, M., Hack, C. E., Veenhof, C. H. N., Romijn, H. A., Sauerwein, H. P., & Poll, T. V. D. (1996) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1650653 · Cited by 279
Self-citationVAN WESTERLOO, D. J., GIEBELEN, I. A. J., MEIJERS, J. C. M., DAALHUISEN, J., DE VOS, A. F., LEVI, M., & VAN DER POLL, T. (2006) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2006.02112.x · Cited by 84
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Metadata
- Authors
- Levi, M., ten Cate, H., Bauer, K. A., van der Poll, T., Edgington, T. S., Büller, H. R., van Deventer, S. J., Hack, C. E., ten Cate, J. W., & Rosenberg, R. D.
- Venue
- Journal of Clinical Investigation
- Published
- 1994-01-01
- Volume
- 93
- Issue
- 1
- Pages
- 114-120
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2125317149
- Cited by
- 406
- References
- 28
- FWCI
- 12.97
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Levi, M., ten Cate, H., Bauer, K. A., van der Poll, T., Edgington, T. S., Büller, H. R., van Deventer, S. J., Hack, C. E., ten Cate, J. W., & Rosenberg, R. D. (1994). Inhibition of endotoxin-induced activation of coagulation and fibrinolysis by pentoxifylline or by a monoclonal anti-tissue factor antibody in chimpanzees. Journal of Clinical Investigation. https://doi.org/10.1172/jci116934
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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