The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Release of early human hematopoietic progenitors from quiescence by antisense transforming growth factor beta 1 or Rb oligonucleotides.
Open accessAbstract
We have used antisense oligonucleotides to study the roles of transforming growth factor beta (TGF-beta) and the two antioncogenes, retinoblastoma susceptibility (Rb) and p53, in the negative regulation of proliferation of early hematopoietic cells in culture. The antisense TGF-beta sequence significantly enhanced the frequency of colony formation by multi-lineage, early erythroid, and granulomonocytic progenitors, but did not affect colony formation by late progenitors. Single cell culture and limiting dilution analysis indicated that autocrine TGF-beta is produced by a subpopulation of early progenitors. Antisense Rb but not antisense p53 yielded similar results in releasing multipotential progenitors (colony-forming unit-granulocyte/erythroid/macrophage/megakaryocyte) from quiescence. Rb antisense could partially reverse the inhibitory effect of exogenous TGF-beta. Anti-TGF-beta blocking antibodies, antisense TGF-beta, or Rb oligonucleotides all had similar effects. No additive effects were observed when these reagents were combined, suggesting a common pathway of action. Our results are consistent with the model that autocrine production of TGF-beta negatively regulates the cycling status of early hematopoietic progenitors through interaction with the Rb gene product.
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Cites
DeCaprio, J. A., Ludlow, J. W., Lynch, D., Furukawa, Y., Griffin, J., Piwnica-Worms, H., Huang, C.-M., & Livingston, D. M. (1989) · Cell · doi:10.1016/0092-8674(89)90507-2 · Cited by 897
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Lataillade, J.-J., Clay, D., Dupuy, C., Rigal, S., Jasmin, C., Bourin, P., & Bousse-Kerdilès, M.-C. L. (2000) · Blood · doi:10.1182/blood.v95.3.756 · Cited by 358
Signaling pathways governing stem-cell fate
Blank, U., Karlsson, G., & Karlsson, S. (2008) · Blood · doi:10.1182/blood-2007-07-075168 · Cited by 355
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Metadata
- Authors
- Hatzfeld, J., Li, M. L., Brown, E. L., Sookdeo, H., Levesque, J. P., O'Toole, T., Gurney, C., Clark, S. C., & Hatzfeld, A.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1991-10-01
- Volume
- 174
- Issue
- 4
- Pages
- 925-929
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2113112343
- Cited by
- 227
- References
- 1
- FWCI
- 4.19
- Type
- journal article
- Language
- en
- Open access
- green
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- Hatzfeld, J., Li, M. L., Brown, E. L., Sookdeo, H., Levesque, J. P., O'Toole, T., Gurney, C., Clark, S. C., & Hatzfeld, A. (1991). Release of early human hematopoietic progenitors from quiescence by antisense transforming growth factor beta 1 or Rb oligonucleotides. The Journal of experimental medicine. https://doi.org/10.1084/jem.174.4.925
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
