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IP-10, a -C-X-C- chemokine, elicits a potent thymus-dependent antitumor response in vivo.
Open accessAbstract
IP-10 is a member of the -C-X-C-chemokine superfamily of proinflammatory cytokines whose secretion is induced by interferon gamma (IFN-gamma) and lipopolysaccharide (LPS). To date no function has been described for IP-10. We have genetically engineered tumor cells to secrete high levels of murine IP-10 and demonstrate that while IP-10 has no effect on the growth of these tumor cells in culture, it elicits a powerful host-mediated antitumor effect in vivo. The IP-10 antitumor response is T lymphocyte dependent, non-cell autonomous, and appears to be mediated by the recruitment of an inflammatory infiltrate composed of lymphocytes, neutrophils, and monocytes. These results document an important biologic property of IP-10 and raise the possibility that some of the T cell-directed effects of IFN-gamma and LPS may be mediated by this chemokine.
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Metadata
- Authors
- Luster, A. D., & Leder, P.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1993-09-01
- Volume
- 178
- Issue
- 3
- Pages
- 1057-1065
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2167711236
- Cited by
- 407
- References
- 0
- FWCI
- 6.10
- Type
- journal article
- Language
- en
- Open access
- green
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