The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
gp39-CD40 interactions are essential for germinal center formation and the development of B cell memory.
Open accessAbstract
gp39, the ligand for CD40 expressed on activated CD4+ T helper cells, is required for the generation of antibody responses to T-dependent (TD) antigens. Treatment of mice with anti-gp39 in vivo inhibits both primary and secondary antibody formation to TD, but not T-independent antigens. However, the role of this receptor-ligand pair in the development of germinal centers and the generation of B cell memory is as yet undefined. Using an antibody to gp39, this study examines the in vivo requirement for gp39-CD40 interactions in the induction of germinal center formation, as well as in the generation of B cell memory. Animals were immunized, treated in vivo with anti-gp39, and evaluated using immunohistochemical staining for the presence of splenic germinal centers 9-11 d after immunization. The results demonstrate that the formation of germinal centers was completely inhibited as a result of treatment with anti-gp39. Moreover, adoptive transfer experiments demonstrate that the generation of antigen-specific memory B cells is also inhibited as a consequence of blocking gp39-CD40 interactions. Taken together, the data demonstrate that gp39-CD40 interactions are critical not only for the generation of antibody responses, but also in the development of B cell memory.
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Cites
Mechanism of antigen-driven selection in germinal centres
Liu, Y.-J., Joshua, D. E., Williams, G. T., Smith, C. A., Gordon, J., & MacLennan, I. C. M. (1989) · Nature · doi:10.1038/342929a0 · Cited by 1,081
Molecular and biological characterization of a murine ligand for CD40
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CD40 Ligand Gene Defects Responsible for X-Linked Hyper-IgM Syndrome
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Self-citationDefective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM
Korthäuer, U., Graf, D., Mages, H. W., Brière, F., Padayachee, M., Malcolm, S., Ugazio, A. G., Notarangelo, L. D., Levinsky, R. J., & Kroczek, R. A. (1993) · Nature · doi:10.1038/361539a0 · Cited by 721
CD40 ligand mutations in X-linked immunodeficiency with hyper-IgM
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Induction of human IgE synthesis in B cells by mast cells and basophils
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Cited by
Follicular Helper CD4 T Cells (T FH )
Crotty, S. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101400 · Cited by 2,738
Immunological memory and protective immunity: understanding their relation
Ahmed, R., & Gray, D. (1996) · Science · doi:10.1126/science.272.5258.54 · Cited by 1,775
Molecular mechanism and function of CD40/CD40L engagement in the immune system
Elgueta, R., Benson, M. J., De Vries, V. C., Wasiuk, A., Guo, Y., & Noelle, R. J. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2009.00782.x · Cited by 1,625
Self-citationMice deficient for the CD40 ligand
Xu, J., Foy, T. M., Laman, J. D., Elliott, E. A., Dunn, J. J., Waldschmidt, T. J., Elsemore, J., Noelle, R. J., & Flavell, R. A. (1994) · Immunity · doi:10.1016/1074-7613(94)90073-6 · Cited by 734
Self-citationDEVELOPMENT AND MATURATION OF SECONDARY LYMPHOID TISSUES
Fu, Y.-X., & Chaplin, D. D. (1999) · Annual Review of Immunology · doi:10.1146/annurev.immunol.17.1.399 · Cited by 616
Metadata
- Authors
- Foy, T. M., Laman, J. D., Ledbetter, J. A., Aruffo, A., Claassen, E., & Noelle, R. J.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1994-07-01
- Volume
- 180
- Issue
- 1
- Pages
- 157-163
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2069784383
- Cited by
- 440
- References
- 34
- FWCI
- 14.20
- Type
- journal article
- Language
- en
- Open access
- green
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- Foy, T. M., Laman, J. D., Ledbetter, J. A., Aruffo, A., Claassen, E., & Noelle, R. J. (1994). gp39-CD40 interactions are essential for germinal center formation and the development of B cell memory. The Journal of experimental medicine. https://doi.org/10.1084/jem.180.1.157
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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