The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Precise prediction of major histocompatibility complex class II-peptide interaction based on peptide side chain scanning.
Open accessAbstract
We describe here a new method for predicting class II major histocompatibility complex-binding peptides, based on the preferences observed in a systematic series of peptide binding experiments where each position in a "minimal" peptide was replaced individually by every amino acid. The DRB1*0401 peptide binding preferences were determined and incorporated into a computer program that looks through sequences for potential epitopes and assigns each a score. These scores correlate well with previously determined T cell epitopes of foreign antigens and endogenous peptides from self proteins. Our findings hold implications for the design of subunit vaccines and in the identification of autoantigenic peptide regions within self proteins.
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Citations
Cites
Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1
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A Molecular Basis for MHC Class II—Associated Autoimmunity
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A sequence pattern common to T cell epitopes.
Rothbard, J. B., & Taylor, W. R. (1988) · The EMBO Journal · doi:10.1002/j.1460-2075.1988.tb02787.x · Cited by 601
MHC Class-II Molecules and Autoimmunity
Nepom, G. T., & Erlich, H. (1991) · Annual Review of Immunology · doi:10.1146/annurev.iy.09.040191.002425 · Cited by 519
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Promiscuous and allele-specific anchors in HLA-DR-binding peptides
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Cited by
SYFPEITHI: database for MHC ligands and peptide motifs
Rammensee, H. G., Bachmann, J., Emmerich, N. P. N., Bachor, O. A., & Stevanović, S. (1999) · Immunogenetics · doi:10.1007/s002510050595 · Cited by 2,314
MHC ligands and peptide motifs: first listing
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Several Common HLA-DR Types Share Largely Overlapping Peptide Binding Repertoires
Southwood, S., Sidney, J., Kondo, A., del Guercio, M.-F., Appella, E., Hoffman, S., Kubo, R. T., Chesnut, R. W., Grey, H. M., & Sette, A. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.7.3363 · Cited by 665
Identification of LFA-1 as a Candidate Autoantigen in Treatment-Resistant Lyme Arthritis
Gross, D. M., Forsthuber, T., Tary-Lehmann, M., Etling, C., Ito, K., Nagy, Z. A., Field, J. A., Steere, A. C., & Huber, B. T. (1998) · Science · doi:10.1126/science.281.5377.703 · Cited by 517
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Metadata
- Authors
- Hammer, J., Bono, E., Gallazzi, F., Belunis, C., Nagy, Z., & Sinigaglia, F.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1994-12-01
- Volume
- 180
- Issue
- 6
- Pages
- 2353-2358
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2021002908
- Cited by
- 290
- References
- 18
- FWCI
- 5.76
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Precise prediction of major histocompatibility complex class II-peptide interaction based on peptide side chain scanning. https://app.cochat.ai/papers/10.1084/jem.180.6.2353
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- Hammer, J., Bono, E., Gallazzi, F., Belunis, C., Nagy, Z., & Sinigaglia, F. (1994). Precise prediction of major histocompatibility complex class II-peptide interaction based on peptide side chain scanning. The Journal of experimental medicine. https://doi.org/10.1084/jem.180.6.2353
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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