The DOI matches its Crossref record.
Cooperation between interleukin-5 and the chemokine eotaxin to induce eosinophil accumulation in vivo.
Open accessAbstract
Experiments were designed to study the effect of systemically administered IL-5 on local eosinophil accumulation induced by the intradermal injection of the chemokine eotaxin in the guinea pig. Intravenous interleukin-5 (IL-5) stimulated a rapid and dramatic increase in the numbers of accumulating eosinophils induced by i.d.-injected eotaxin and, for comparison, leukotriene B4. The numbers of locally accumulating eosinophils correlated directly with a rapid increase in circulating eosinophils: circulating eosinophil numbers were 13-fold higher 1 h after intravenous IL-5 (18.3 pmol/kg). This increase in circulating cells corresponded with a reduction in the number of displaceable eosinophils recovered after flushing out the femur bone marrow cavity. Intradermal IL-5, at the doses tested, did not induce significant eosinophil accumulation. We propose that these experiments simulate important early features of the tissue response to local allergen exposure in a sensitized individual, with eosinophil chemoattractant chemokines having an important local role in eosinophil recruitment from blood microvessels, and IL-5 facilitating this process by acting remotely as a hormone to stimulate the release into the circulation of a rapidly mobilizable pool of bone marrow eosinophils. This action of IL-5 would be complementary to the other established activities of IL-5 that operate over a longer time course.
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Citations
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Gonzalo, J.-A., Pan, Y., Lloyd, C. M., Jia, G.-Q., Yu, G., Dussault, B., Powers, C. A., Proudfoot, A. E. I., Coyle, A. J., Gearing, D., et al. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.1.403 · Cited by 248
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Diny, N. L., Rose, N. R., & Čiháková, D. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00484 · Cited by 172
Culley, F. J., Brown, A., Conroy, D. M., Sabroe, I., Pritchard, D. I., & Williams, T. J. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.11.6447 · Cited by 138
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Shurin, G. V., Yurkovetsky, Z. R., Chatta, G. S., Tourkova, I. L., Shurin, M. R., & Lokshin, A. E. (2007) · Cytokine · doi:10.1016/j.cyto.2007.06.006 · Cited by 95
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Diny, N. L., Hou, X., Barin, J. G., Chen, G., Talor, M. V., Schaub, J., Russell, S. D., Klingel, K., Rose, N. R., & Čiháková, D. (2016) · European Journal of Immunology · doi:10.1002/eji.201646557 · Cited by 70
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TERADA, N., HAMANO, N., KIM, W. J., HIRAI, K., NAKAJIMA, T., YAMADA, H., KAWASAKI, H., YAMASHITA, T., KISHI, H., NOMURA, T., et al. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.164.4.2009046 · Cited by 53
Casaro, M. B., Thomas, A. M., Mendes, E., Fukumori, C., Ribeiro, W. R., Oliveira, F. A., Crisma, A. R., Murata, G. M., Bizzarro, B., Sá-Nunes, A., et al. (2021) · Microbiome · doi:10.1186/s40168-021-01081-2 · Cited by 24
Metadata
- Authors
- Collins, P. D., Marleau, S., Griffiths-Johnson, D. A., Jose, P. J., & Williams, T. J.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1995-10-01
- Volume
- 182
- Issue
- 4
- Pages
- 1169-1174
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2141701917
- Cited by
- 658
- References
- 0
- FWCI
- 19.85
- Type
- journal article
- Language
- en
- Open access
- green
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