The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Chronic inflammation caused by lymphotoxin is lymphoid neogenesis.
Open accessAbstract
In presenting a unifying concept for chronic inflammation and lymphoid organogenesis, we suggest that lymphotoxin's (LT, LT-alpha, TNF-beta) crucial role in these processes is pivotal and similar. Chronic inflammatory lesions that developed in the kidney and pancreas at the sites of transgene expression in rat insulin promoter-LT (RIP-LT) mice resembled lymph nodes with regard to cellular composition (T cells, B cells, plasma cells, and antigen-presenting cells), delineated T and B cell areas, primary and secondary follicles, characteristic morphologic and antigenic (ICAM-1, VCAM-1, MAdCAM-1, and PNAd) features of high endothelial venules, and ability to respond to antigen and undergo Ig class switching when obtained from mice immunized with SRBC. The vascular changes, with the exception of PNAd, appear to be the direct consequence of transgene derived LT expression, as they were also observed in RIP-LT mice lacking mature T and B cells. These data show that LT-induced chronic inflammation has the characteristics of organized lymphoid tissue.
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PERIODATE-LYSINE-PARAFORMALDEHYDE FIXATIVE A NEW FIXATIVE FOR IMMUNOELECTRON MICROSCOPY
MCLEAN, I. W., & NAKANE, P. K. (1974) · Journal of Histochemistry & Cytochemistry · doi:10.1177/22.12.1077 · Cited by 3,798
RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement
Shinkai, Y. (1992) · Cell · doi:10.1016/0092-8674(92)90029-c · Cited by 2,150
Regulatory T Cell Clones Induced by Oral Tolerance: Suppression of Autoimmune Encephalomyelitis
Chen, Y., Kuchroo, V. K., Inobe, J.-I., Hafler, D. A., & Weiner, H. L. (1994) · Science · doi:10.1126/science.7520605 · Cited by 1,973
Selected methods in cellular immunology
(1981) · Annales de l'Institut Pasteur / Immunologie · doi:10.1016/0769-2625(81)90037-4 · Cited by 1,959
Old, L. J. (1985) · Science · doi:10.1126/science.2413547 · Cited by 1,895
Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis.
Keffer, J., Probert, L., Cazlaris, H., Georgopoulos, S., Kaslaris, E., Kioussis, D., & Kollias, G. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb04978.x · Cited by 1,660
Abnormal Development of Peripheral Lymphoid Organs in Mice Deficient in Lymphotoxin
De Togni, P., Goellner, J., Ruddle, N. H., Streeter, P. R., Fick, A., Mariathasan, S., Smith, S. C., Carlson, R., Shornick, L. P., Strauss-Schoenberger, J., et al. (1994) · Science · doi:10.1126/science.8171322 · Cited by 986
Self-citationA tissue-specific endothelial cell molecule involved in lymphocyte homing
Streeter, P. R., Berg, E. L., Rouse, B. T. N., Bargatze, R. F., & Butcher, E. C. (1988) · Nature · doi:10.1038/331041a0 · Cited by 719
Ruddle, N. H., Bergman, C. M., McGrath, K. M., Lingenheld, E. G., Grunnet, M. L., Padula, S. J., & Clark, R. B. (1990) · The Journal of experimental medicine · doi:10.1084/jem.172.4.1193 · Cited by 688
Self-citationPhysiological and Molecular Mechanisms of Lymphocyte Homing
Picker, L. J., & Butcher, E. C. (1992) · Annual Review of Immunology · doi:10.1146/annurev.iy.10.040192.003021 · Cited by 657
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Locksley, R. M., Killeen, N., & Lenardo, M. J. (2001) · Cell · doi:10.1016/s0092-8674(01)00237-9 · Cited by 3,650
Tumor necrosis factor antagonist mechanisms of action: A comprehensive review
Tracey, D., Klareskog, L., Sasso, E. H., Salfeld, J. G., & Tak, P. P. (2008) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.10.001 · Cited by 1,628
Lymphoid neogenesis in chronic inflammatory diseases
Aloisi, F., & Pujol-Borrell, R. (2006) · Nature Reviews Immunology · doi:10.1038/nri1786 · Cited by 908
Fütterer, A., Mink, K., Luz, A., Kosco-Vilbois, M. H., & Pfeffer, K. (1998) · Immunity · doi:10.1016/s1074-7613(00)80588-9 · Cited by 732
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Pitzalis, C., Jones, G. W., Bombardieri, M., & Jones, S. A. (2014) · Nature Reviews Immunology · doi:10.1038/nri3700 · Cited by 698
Metadata
- Authors
- Kratz, A., Campos-Neto, A., Hanson, M. S., & Ruddle, N. H.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1996-04-01
- Volume
- 183
- Issue
- 4
- Pages
- 1461-1472
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2048706422
- Cited by
- 431
- References
- 51
- FWCI
- 6.90
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
