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Cited by 351

The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.

Interferon gamma production by natural killer (NK) cells and NK1.1+ T cells upon NKR-P1 cross-linking.

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Arase, H, Arase, N, Saito, T·1996·The Journal of experimental medicine
DOI 10.1084/jem.183.5.2391
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Abstract

Natural killer (NK) cells play an important role in immune response by producing interferon gamma (IFN-gamma) as well as exhibiting cytotoxic function. IFN-gamma produced by NK cells has been suggested to be involved in differentiation of T helper cells. On the other hand, the NKR-P1 molecule was recently identified as one of the important NK cell receptors, and it recognizes certain kinds of oligosaccharides on target cells and triggers NK cells for cytotoxicity. In the present study, we found that NK cells produce great amounts of IFN-gamma upon cross-linking of the NKR-P1 molecule. In contrast, stimulation of NK cells with IL-2 induced proliferation without producing IFN-gamma. Similar to NK cells, NK1.1+ T cells also produced IFN-gamma upon NKR-P1 cross-linking. NK1.1+ T cells produced IFN-gamma but not interleukin 4 (IL-4) upon NKR-P1 cross-linking, whereas they secreted both IFN-gamma and IL-4 upon T cell receptor cross-linking. These results indicate that NKR-P1 is a receptor molecule on NK and NK1.1+ T cells that induces not only cytotoxicity but also IFN-gamma production. Our findings provide a new pathway for IFN-gamma production by NK and NK1.1+ T cells through NKR-P1 molecules; it may be essential for immune regulation.

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Crossref · 10.1084/jem.183.5.2391

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Metadata

Authors
Arase, H., Arase, N., & Saito, T.
Venue
The Journal of experimental medicine
Publisher
Rockefeller University Press
Published
1996-05-01
Volume
183
Issue
5
Pages
2391-2396
ISSN
  • 0022-1007 (ISSN-L)
  • 1540-9538
DOI
10.1084/jem.183.5.2391
OpenAlex
W2070692001
Cited by
351
References
27
FWCI
11.41
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Interferon gamma production by natural killer (NK) cells and NK1.1+ T cells upon NKR-P1 cross-linking. https://app.cochat.ai/papers/10.1084/jem.183.5.2391
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Arase, H., Arase, N., & Saito, T. (1996). Interferon gamma production by natural killer (NK) cells and NK1.1+ T cells upon NKR-P1 cross-linking. The Journal of experimental medicine. https://doi.org/10.1084/jem.183.5.2391

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.