The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Accelerated Nerve Regeneration in Mice by upregulated expression of interleukin (IL) 6 and IL-6 receptor after trauma.
Open accessAbstract
In this study we aimed to examine a role for interleukin 6 (IL-6) and its receptor (IL-6R) in peripheral nerve regeneration in vivo. We first observed that cultured mouse embryonic dorsal root ganglia exhibited dramatic neurite extension by simultaneous addition of IL-6 and soluble IL-6R (sIL-6R), a complex that is known to interact with and activate a signal transducing receptor component, gp130. After injury in the hypoglossal nerve in adult mice by ligation, immunoreactivity to IL-6 was upregulated in Schwann cells at the lesional site as well as in the cell bodies of hypoglossal neurons in the brain stem. In the latter, upregulation of the immunoreactivity to IL-6R was also observed. Regeneration of axotomized hypoglossal nerve in vivo was significantly retarded by the administration of anti-IL-6R antibody. Surprisingly, accelerated regeneration of the axotomized nerve was achieved in transgenic mice constitutively expressing both IL-6 and IL-6R, as compared with nontransgenic controls. These results suggest that the IL-6 signal may play an important role in nerve regeneration after trauma in vivo.
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“ing monocytes /macrophages (1), T cells (2), fibroblasts (3, 4), and endothelial cells (5, 6) in response to diverse stimuli.”
Self-citationInterleukin-6 triggers the association of its receptor with a possible signal transducer, gp130
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Self-citationProduction of hybridoma growth factor by human monocytes
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Molecular cloning and expression of an IL-6 signal transducer, gp130
Hibi, M., Murakami, M., Saito, M., Hirano, T., Taga, T., & Kishimoto, T. (1990) · Cell · doi:10.1016/0092-8674(90)90411-7 · Cited by 1,039
Self-citationGearing, D. P., Comeau, M. R., Friend, D. J., Gimpel, S. D., Thut, C. J., McGourty, J., Brasher, K. K., King, J. A., Gillis, S., Mosley, B., et al. (1992) · Science · doi:10.1126/science.1542794 · Cited by 889
Ciliary neurotrophic factor prevents the degeneration of motor neurons after axotomy
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Self-citationInterleukin-6 and its receptor: a paradigm for cytokines
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Cited by
The soluble interleukin 6 receptor: mechanisms of production and implications in disease
JONES, S. A., HORIUCHI, S., TOPLEY, N., YAMAMOTO, N., & FULLER, G. M. (2001) · The FASEB Journal · doi:10.1096/fj.99-1003rev · Cited by 623
The role of interleukin-6 signaling in nervous tissue
Rothaug, M., Becker-Pauly, C., & Rose-John, S. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2016.03.018 · Cited by 491
Interleukin-6 (IL-6)—A molecule with both beneficial and destructive potentials
Gadient, R. A., & Otten, U. H. (1997) · Progress in Neurobiology · doi:10.1016/s0301-0082(97)00021-x · Cited by 481
The Success and Failure of the Schwann Cell Response to Nerve Injury
Jessen, K. R., & Mirsky, R. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00033 · Cited by 466
The neuropoietic cytokine family in development, plasticity, disease and injury
Bauer, S., Kerr, B. J., & Patterson, P. H. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2054 · Cited by 419
Metadata
- Authors
- Hirota, H., Kiyama, H., Kishimoto, T., & Taga, T.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1996-06-01
- Volume
- 183
- Issue
- 6
- Pages
- 2627-2634
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W1980148614
- Cited by
- 321
- References
- 43
- FWCI
- 7.13
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Accelerated Nerve Regeneration in Mice by upregulated expression of interleukin (IL) 6 and IL-6 receptor after trauma. https://app.cochat.ai/papers/10.1084/jem.183.6.2627
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- Hirota, H., Kiyama, H., Kishimoto, T., & Taga, T. (1996). Accelerated Nerve Regeneration in Mice by upregulated expression of interleukin (IL) 6 and IL-6 receptor after trauma. The Journal of experimental medicine. https://doi.org/10.1084/jem.183.6.2627
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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