Cited by 810T-cell and B-cell ImmunologyPsoriasis: Treatment and PathogenesisCytokine Signaling Pathways and Interactions

The DOI matches its Crossref record; 51 of the 55 references it cites were found in a registry or an index.

Interleukin (IL)-6 directs the differentiation of IL-4-producing CD4+ T cells

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Rincón, Mercedes, Anguita, Juan, Nakamura, Tetsuo, Fikrig, Erol, Flavell, Richard A.·1997·The Journal of Experimental Medicine

Abstract

Interleukin (IL)-4 is the most potent factor that causes naive CD4+ T cells to differentiate to the T helper cell (Th) 2 phenotype, while IL-12 and interferon γ trigger the differentiation of Th1 cells. However, the source of the initial polarizing IL-4 remains unclear. Here, we show that IL-6, probably secreted by antigen-presenting cells, is able to polarize naive CD4+ T cells to effector Th2 cells by inducing the initial production of IL-4 in CD4+ T cells. These results show that the nature of the cytokine (IL-12 or IL-6), which is produced by antigen-presenting cells in response to a particular pathogen, is a key factor in determining the nature of the immune response.

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  1. Chomczynski, 1987, Single-step method of RNA extraction by acid guanidinium thiocyanate-phenolchloroform, Anal Biochem, 162, 156, 10.1016/0003-2697(87)90021-2 · DOI

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Metadata

Authors
Rincón, M., Anguita, J., Nakamura, T., Fikrig, E., & Flavell, R. A.
Affiliations
  • Howard Hughes Medical Institute (US)
  • From the *Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520-8011; ‡Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520-9031; and §Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06520-8011
Venue
The Journal of Experimental Medicine
Published
1997-02-03
Volume
185
Issue
3
Pages
461-470
ISSN
  • 0022-1007 (ISSN-L)
  • 1540-9538
OpenAlex
W2150763544
Cited by
810
References
55
Citations by year
2026: 3 · 2025: 11 · 2024: 14 · 2023: 18 · 2022: 20 · 2021: 23 · 2020: 23 · 2019: 19 · 2018: 19 · 2017: 15 · 2016: 18 · 2015: 16 · 2014: 30 · 2013: 9 · 2012: 25
FWCI
29.64
Type
journal article
Language
en
Open access
Licence
cc-by-nc-sa
Locations
  • The Journal of Experimental Medicine (publishedVersion)
  • PubMed Central (publishedVersion, cc-by-nc-sa)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5p01ai030548-09)
  • National Cancer Institute (CA-65861, R01CA065861)
  • National Institute of Allergy and Infectious Diseases (1-P01-AI30548)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
  • Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Keywords
interleukin-6, IL-4, CD4+ T cells, Th2 differentiation, Th1 differentiation, antigen-presenting cells, immune regulation
MeSH terms
Animals, Antigen-Presenting Cells, Cell Differentiation, Mice, Inbred C57BL, CD4-Positive T-Lymphocytes, Interleukin-4, Interleukin-6, Mice

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