Premature ageing of the immune system: the cause of AIDS?
Abstract
The reasons for the failure of the immune system to control HIV-1 infection, and the resulting immunodeficiency, remain unclear. HIV-1 persists in its host despite vigorous immune responses, including a strong, and probably functional, HIV-specific cytotoxic T-lymphocyte response. Interestingly the immunological features of HIV-1-infected individuals show many similarities to those seen in elderly people without HIV infection. We propose that, through a process of continuous immune activation, HIV-1 infection leads to an acceleration of the adaptive immune system ageing process, resulting in premature exhaustion of immune resources, which participates in the onset of immunodeficiency. This hypothesis might shed new light on HIV-1 pathogenesis and could suggest the need to reconsider current immunotherapeutic strategies to fight the virus.
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Numerous aspects of immune and cellular senescence have been documented in the elderly, but only a few of them have been extended to studies in HIV-infected individuals.
“There are numerous aspects of immune and cellular senescence that have been documented in the elderly but only a few of them have been extended to studies in HIV-infected individuals (31,32).”
From HIV and Aging: State of Knowledge and Areas of Critical Need for Research. A Report to the NIH Office of AIDS Research by the HIV and Aging Working Group (2012) · cites this paper as [32]
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- Authors
- Appay, V., & Rowland-Jones, S. L.
- Affiliations
- John Radcliffe Hospital (GB)
- Corresponding author
- Appay, Victor
- ORCID
- Appay, Victor
- Venue
- Trends in Immunology
- Publisher
- Elsevier BV
- Published
- 2002-12
- Volume
- 23
- Issue
- 12
- Pages
- 580-585
- ISSN
- 1471-4906 (ISSN-L)
- OpenAlex
- W2157134016
- Cited by
- 173
- References
- 75
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 5 · 2020: 7 · 2019: 4 · 2018: 5 · 2017: 4 · 2016: 5 · 2015: 5 · 2014: 2 · 2013: 8 · 2012: 12
- FWCI
- 1.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Health Sciences › Medicine › Emergency Medicine › HIV-related health complications and treatments
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- HIV-1 infection, immunodeficiency, immune activation, cytotoxic T lymphocytes, HIV-specific immune response, HIV pathogenesis
- MeSH terms
- Acquired Immunodeficiency Syndrome, Humans, CD4-Positive T-Lymphocytes, HIV-1, CD8-Positive T-Lymphocytes, Models, Immunological, Aging, Premature
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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