Cited by 173HIV Research and TreatmentHIV-related health complications and treatmentsT-cell and B-cell Immunology

Premature ageing of the immune system: the cause of AIDS?

Appay, Victor, Rowland-Jones, Sarah L.·2002·Trends in Immunology

Abstract

The reasons for the failure of the immune system to control HIV-1 infection, and the resulting immunodeficiency, remain unclear. HIV-1 persists in its host despite vigorous immune responses, including a strong, and probably functional, HIV-specific cytotoxic T-lymphocyte response. Interestingly the immunological features of HIV-1-infected individuals show many similarities to those seen in elderly people without HIV infection. We propose that, through a process of continuous immune activation, HIV-1 infection leads to an acceleration of the adaptive immune system ageing process, resulting in premature exhaustion of immune resources, which participates in the onset of immunodeficiency. This hypothesis might shed new light on HIV-1 pathogenesis and could suggest the need to reconsider current immunotherapeutic strategies to fight the virus.

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Authors
Appay, V., & Rowland-Jones, S. L.
Affiliations
John Radcliffe Hospital (GB)
Corresponding author
Appay, Victor
Venue
Trends in Immunology
Publisher
Elsevier BV
Published
2002-12
Volume
23
Issue
12
Pages
580-585
ISSN
1471-4906 (ISSN-L)
OpenAlex
W2157134016
Cited by
173
References
75
Citations by year
2026: 1 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 5 · 2020: 7 · 2019: 4 · 2018: 5 · 2017: 4 · 2016: 5 · 2015: 5 · 2014: 2 · 2013: 8 · 2012: 12
FWCI
1.72
Type
journal article
Language
en
Open access
closed
Locations
  • Trends in Immunology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
  • Health Sciences › Medicine › Emergency Medicine › HIV-related health complications and treatments
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords
HIV-1 infection, immunodeficiency, immune activation, cytotoxic T lymphocytes, HIV-specific immune response, HIV pathogenesis
MeSH terms
Acquired Immunodeficiency Syndrome, Humans, CD4-Positive T-Lymphocytes, HIV-1, CD8-Positive T-Lymphocytes, Models, Immunological, Aging, Premature

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