The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
T Cell Affinity Maturation by Selective Expansion during Infection
Open accessAbstract
T lymphocyte recognition of infected cells is mediated by T cell receptors (TCRs) interacting with their ligands, self–major histocompatibility complex (MHC) molecules complexed with pathogen-derived peptides. Serial TCR interactions with potentially small numbers of MHC/ peptide complexes on infected cells transmit signals that result in T lymphocyte expansion and activation of effector functions. The impact of TCR affinity for MHC/peptide complexes on the rate or extent of in vivo T cell expansion is not known. Here we show that in vivo expansion of complex T cell populations after bacterial infection is accompanied by an increase in their overall affinity for antigen. T cell populations that have undergone additional rounds of in vivo expansion express a narrower range of TCRs, have increased sensitivity for antigen in cytotoxic T lymphocyte assays, and bind MHC/peptide complexes with greater affinity. The selective expansion of higher affinity T cells provides an in vivo mechanism for optimizing the early detection of infected cells.
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Cites
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Self-citation
Cited by
Effector and memory T-cell differentiation: implications for vaccine development
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CTLA-4 in Regulatory T Cells for Cancer Immunotherapy
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Regulatory T Cells Increase the Avidity of Primary CD8 + T Cell Responses and Promote Memory
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Metadata
- Authors
- Busch, D. H., & Pamer, E. G.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 1999-02-15
- Volume
- 189
- Issue
- 4
- Pages
- 701-710
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2058634008
- Cited by
- 406
- References
- 35
- FWCI
- 11.43
- Type
- journal article
- Language
- en
- Open access
- bronze
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