The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Interferon γ Eliminates Responding Cd4 T Cells during Mycobacterial Infection by Inducing Apoptosis of Activated Cd4 T Cells
Open accessAbstract
In Mycobacterium bovis Bacille Calmette-Guérin (BCG)-infected wild-type mice, there was a large expansion of an activated (CD44hi) splenic CD4 T cell population followed by a rapid contraction of this population to normal numbers. Contraction of the activated CD4 T cell population in wild-type mice was associated with increased apoptosis of activated CD4 T cells. In BCG-infected interferon (IFN)-γ knockout (KO) mice, the activated CD4 T cell population did not undergo apoptosis. These mice accumulated large numbers of CD4+CD44hi T cells that were responsive to mycobacterial antigens. Addition of IFN-γ to cultured splenocytes from BCG-infected IFN-γ KO mice induced apoptosis of activated CD4 T cells. IFN-γ–mediated apoptosis was abolished by depleting adherent cells or Mac-1+ spleen cells or by inhibiting nitric oxide synthase. Thus, IFN-γ is essential to a regulatory mechanism that eliminates activated CD4 T cells and maintains CD4 T cell homeostasis during an immune response.
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Cites
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Cited by
Nitric oxide and the immune response
Bogdan, C. (2001) · Nature Immunology · doi:10.1038/ni1001-907 · Cited by 3,447
Regulation of Antigen-Specific CD8 + T Cell Homeostasis by Perforin and Interferon-γ
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Metadata
- Authors
- Dalton, D. K., Haynes, L., Chu, C.-Q., Swain, S. L., & Wittmer, S.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2000-07-03
- Volume
- 192
- Issue
- 1
- Pages
- 117-122
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2144303909
- Cited by
- 331
- References
- 26
- FWCI
- 10.46
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Interferon γ Eliminates Responding Cd4 T Cells during Mycobacterial Infection by Inducing Apoptosis of Activated Cd4 T Cells. https://app.cochat.ai/papers/10.1084/jem.192.1.117
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- Dalton, D. K., Haynes, L., Chu, C.-Q., Swain, S. L., & Wittmer, S. (2000). Interferon γ Eliminates Responding Cd4 T Cells during Mycobacterial Infection by Inducing Apoptosis of Activated Cd4 T Cells. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.192.1.117
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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