The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Differential Effects of Notch Ligands Delta-1 and Jagged-1 in Human Lymphoid Differentiation
Open accessAbstract
Notch signaling is known to differentially affect the development of lymphoid B and T cell lineages, but it remains unclear whether such effects are specifically dependent on distinct Notch ligands. Using a cell coculture assay we observed that the Notch ligand Delta-1 completely inhibits the differentiation of human hematopoietic progenitors into the B cell lineage while promoting the emergence of cells with a phenotype of T cell/natural killer (NK) precursors. In contrast, Jagged-1 did not disturb either B or T cell/NK development. Furthermore, cells cultured in the presence of either Delta-1 or Jagged-1 can acquire a phenotype of NK cells, and Delta-1, but not Jagged-1, permits the emergence of a de novo cell population coexpressing CD4 and CD8. Our results thus indicate that distinct Notch ligands can mediate differential effects of Notch signaling and provide a useful system to further address cell-fate decision processes in lymphopoiesis.
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Cites
Identification of Clonogenic Common Lymphoid Progenitors in Mouse Bone Marrow
Kondo, M., Weissman, I. L., & Akashi, K. (1997) · Cell · doi:10.1016/s0092-8674(00)80453-5 · Cited by 2,253
Cited by
Induction of T Cell Development from Hematopoietic Progenitor Cells by Delta-like-1 In Vitro
Schmitt, T. M., & Zúñiga-Pflücker, J. C. (2002) · Immunity · doi:10.1016/s1074-7613(02)00474-0 · Cited by 1,120
WNT signalling in the immune system: WNT is spreading its wings
Staal, F. J. T., Luis, T. C., & Tiemessen, M. M. (2008) · Nature Reviews Immunology · doi:10.1038/nri2360 · Cited by 582
Notch Signaling in the Immune System
Radtke, F., Fasnacht, N., & MacDonald, H. R. (2010) · Immunity · doi:10.1016/j.immuni.2010.01.004 · Cited by 543
Notch regulation of lymphocyte development and function
Radtke, F., Wilson, A., Mancini, S. J. C., & MacDonald, H. R. (2004) · Nature Immunology · doi:10.1038/ni1045 · Cited by 539
Koch, U., Fiorini, E., Benedito, R., Besseyrias, V., Schuster-Gossler, K., Pierres, M., Manley, N. R., Duarte, A., MacDonald, H. R., & Radtke, F. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20080829 · Cited by 464
Metadata
- Authors
- Jaleco, A. C., Neves, H., Hooijberg, E., Gameiro, P., Clode, N., Haury, M., Henrique, D., & Parreira, L.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2001-10-01
- Volume
- 194
- Issue
- 7
- Pages
- 991-1002
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2096015304
- Cited by
- 345
- References
- 1
- FWCI
- 8.03
- Type
- journal article
- Language
- en
- Open access
- green
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- Jaleco, A. C., Neves, H., Hooijberg, E., Gameiro, P., Clode, N., Haury, M., Henrique, D., & Parreira, L. (2001). Differential Effects of Notch Ligands Delta-1 and Jagged-1 in Human Lymphoid Differentiation. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.194.7.991
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