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Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

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PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo

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MD-2, a Molecule that Confers Lipopolysaccharide Responsiveness on Toll-like Receptor 4

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Hyaluronan 1

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Cutting Edge: Heat Shock Protein 60 Is a Putative Endogenous Ligand of the Toll-Like Receptor-4 Complex

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Toll-like Receptor 2 Functions as a Pattern Recognition Receptor for Diverse Bacterial Products*

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Early Blockade of TLRs MyD88-Dependent Pathway May Reduce Secondary Spinal Cord Injury in the Rats

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An adjuvant role of in situ dendritic cells (DCs) in linking innate and adaptive immunity

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Hyaluronan Oligosaccharides Induce MMP-1 and -3 via Transcriptional Activation of NF-κB and p38 MAPK in Rheumatoid Synovial Fibroblasts

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Role of bacterial infections in allograft rejection

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Adjusting Cell‐Surface Interactions Through a Covalent Immobilization of Biomolecules

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Development of a macrophage polarization-modulating therapeutic agent for osteoarthritis treatment

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Therapeutic Effects of Hyaluronic Acid in Peritonitis-Induced Sepsis in Mice

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Hyaluronidase-Functionalized Silica Nanocarrier for Enhanced Chemo-Immunotherapy through Inducing Immunogenic Cell Death

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Hypoxia-inducing cryogels uncover key cancer-immune cell interactions in an oxygen-deficient tumor microenvironment

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Maintenance of homeostasis by TLR4 ligands

Oda, M., Yamamoto, H., & Kawakami, T. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1286270 · Cited by 20

The decreased secretion of hyaluronan by older human fibroblasts under physiological conditions is mainly associated with the down-regulated expression of hyaluronan synthases but not with the expression levels of hyaluronidases

Terazawa, S., Nakajima, H., Tobita, K., & Imokawa, G. (2014) · Cytotechnology · doi:10.1007/s10616-014-9707-2 · Cited by 20

Profiles of carbohydrate ligands associated with adsorbed proteins on self‐assembled monolayers of defined chemistries

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Reconstituted High-Density Lipoprotein Modulates Activation of Human Leukocytes

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Primers on Molecular Pathways: Lipopolysaccharide Signaling — Potential Role in Pancreatitis and Pancreatic Cancer

del Pozo, J. L. (2010) · Pancreatology · doi:10.1159/000299987 · Cited by 19

New findings in allergic contact dermatitis

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Synergy of GHK‐Cu and hyaluronic acid on collagen IV upregulation via fibroblast and ex‐vivo skin tests

Jiang, F., Wu, Y., Liu, Z., Hong, M., & Huang, Y. (2023) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.15763 · Cited by 18

Hyaluronan Binding Identifies a Functionally Distinct Alveolar Macrophage–like Population in Bone Marrow–Derived Dendritic Cell Cultures

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Endogenous Ligands for TLR2 and TLR4 Are Not Involved in Renal Injury following Ureteric Obstruction

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Multi‐Gram Synthesis of a Hyaluronic Acid Subunit and Synthesis of Fully Protected Oligomers

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A nin vitroinvestigation of the marked impact of dendritic cell interactions with bone grafts

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Hyaluronic acid optimises therapeutic effects of hydrogen peroxide‐induced oxidative stress on breast cancer

Abbasi, A., Pakravan, N., & Hassan, Z. M. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.29957 · Cited by 19

The Role of Hyaluronic Acid in Intervertebral Disc Regeneration

Kazezian, Z., Joyce, K., & Pandit, A. S. (2020) · Applied Sciences · doi:10.3390/app10186257 · Cited by 18

Effect of Tape Stripping and Adjuvants on Immune Response After Intradermal DNA Electroporation

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Genotypic analysis of Asp299Gly and Thr399Ile polymorphism of Toll-like receptor 4 in systemic autoimmune diseases of Korean population

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Alginate oligomer induces nitric oxide (NO) production in RAW264.7 cells: elucidation of the underlying intracellular signaling mechanism

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Alteration in immune responses toward N-deacetylation of hyaluronic acid

Zhang, W., Mu, H., Dong, D., Wang, D., Zhang, A., & Duan, J. (2014) · Glycobiology · doi:10.1093/glycob/cwu079 · Cited by 18

Involvement of Ubiquitin-Editing Protein A20 in Modulating Inflammation in Rat Cochlea Associated with Silver Nanoparticle-Induced CD68 Upregulation and TLR4 Activation

Feng, H., Pyykkö, I. V., & Zou, J. (2016) · Nanoscale Research Letters · doi:10.1186/s11671-016-1430-9 · Cited by 18

The pivotal role of p38 and NF-κB signal pathways in the maturation of human monocyte-derived dendritic cells stimulated by streptococcal agent OK-432

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Expression and activity of Runx2 mediated by hyaluronan during chondrocyte differentiation

Tanne, Y., Tanimoto, K., Tanaka, N. K., et al. (2008) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2007.12.007 · Cited by 18

Glycovaccinology: The design and engineering of carbohydrate-based vaccine components

Hulbert, S. W., Desai, P., Jewett, M. C., DeLisa, M. P., & Williams, A. J. (2023) · Biotechnology Advances · doi:10.1016/j.biotechadv.2023.108234 · Cited by 19

The skin sensitization adverse outcome pathway: exploring the role of mechanistic understanding for higher tier risk assessment

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Growth factor and cytokine expression of human mesenchymal stromal cells is not altered in an in vitro model of tissue damage

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The association of Toll-like receptor 4 gene polymorphisms with the development of emphysema in Japanese subjects: a case control study

Ito, M., Hanaoka, M., Droma, Y., Kobayashi, N., Yasuo, M., Kitaguchi, Y., Horiuchi, T., Ikegawa, K., Katsuyama, Y., Kubo, K., et al. (2012) · BMC Research Notes · doi:10.1186/1756-0500-5-36 · Cited by 17

Rabeximod reduces arthritis severity in mice by decreasing activation of inflammatory cells

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TGF-β1 Is Present at High Levels in Wound Fluid from Breast Cancer Patients Immediately Post-Surgery, and Is Not Increased by Intraoperative Radiation Therapy (IORT)

Scherer, S. D., Bauer, J., Schmaus, A., Neumaier, C., Herskind, C., Veldwijk, M. R., Wenz, F. K., & Sleeman, J. P. (2016) · PLoS ONE · doi:10.1371/journal.pone.0162221 · Cited by 20

Contact allergen (PPD and DNCB)-induced keratinocyte sensitization is partly mediated through a low molecular weight hyaluronan (LMWHA)/TLR4/NF-κB signaling axis

Kavasi, R., Berdiaki, A., Spyridaki, I., Papoutsidakis, A., Corsini, E., Tsatsakis, A. M., Tzanakakis, G. N., & Nikitovic, D. (2019) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2019.114632 · Cited by 19

Biological activities of cytokine-neutralizing hyaluronic acid-antibody conjugates

Sun, L. T., Bencherif, S. A., Gilbert, T. W., Farkas, A. M., Lotze, M. T., & Washburn, N. R. (2010) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2010.00591.x · Cited by 17

Type-1 interferons contribute to oxygen glucose deprivation induced neuro-inflammation in BE(2)M17 human neuroblastoma cells

Minter, M. R., Zhang, M., Ates, R., Taylor, J. M., & Crack, P. J. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-43 · Cited by 17

Expression of functional Toll‐like receptors and nucleotide‐binding oligomerization domain proteins in murine cementoblasts and their upregulation during cell differentiation

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Diphtheria toxoid dissolving microneedle vaccination: Adjuvant screening and effect of repeated-fractional dose administration

Leone, M., Romeijn, S. G., Du, G., Dévédec, S. E. L., Vrieling, H., O’Mahony, C., Bouwstra, J. A., & Kersten, G. F. A. (2020) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2020.119182 · Cited by 17

The Function of Toll-Like Receptors

Dembić, Z. (2005) · Springer eBooks · doi:10.1007/0-387-27445-6_2 · Cited by 20

Prostaglandin E2: A potent activator of hyaluronan synthase 1 in type-B-synoviocytes

Stuhlmeier, K. M. (2006) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2006.07.001 · Cited by 18

Endothelial dysfunction sustains immune response in atherosclerosis: potential cause for ineffectiveness of prevailing drugs

Akhtar, S., & Sharma, A. (2021) · International Reviews of Immunology · doi:10.1080/08830185.2020.1866568 · Cited by 15

The Attenuated Secretion of Hyaluronan by UVA-Exposed Human Fibroblasts Is Associated with Up- and Downregulation of HYBID and HAS2 Expression via Activated and Inactivated Signaling of the p38/ATF2 and JAK2/STAT3 Cascades

Terazawa, S., Takada, M., Sato, Y., Nakajima, H., & Imokawa, G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22042057 · Cited by 17

The role of hyaluronan synthesis and degradation in the critical respiratory illness COVID-19

Albtoush, N., & Petrey, A. C. (2022) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00071.2022 · Cited by 16

Matrix‐Bound Hyaluronan Molecular Weight as a Regulator of Dendritic Cell Immune Potency

Quartey, B. C., Sapudom, J., ElGindi, M., Alatoom, A., & Teo, J. C. M. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202303125 · Cited by 16

Hyaluronan‐protein interactions: Lilliput revisited

Day, A. J. (2024) · Proteoglycan Research · doi:10.1002/pgr2.70007 · Cited by 18

ABCB1 transporter and Toll-like receptor 4 in trabecular meshwork cells.

Grybauskas, A., Koga, T., Kuprys, P. V., Nolan, M. J., McCarty, R. D., Walker, L., Green, K. A., Norkett, W. M., Yue, B. Y. J. T., & Knepper, P. A. (2015) · Europe PMC (PubMed Central) · Cited by 16

Over‐expression of Toll‐like receptors and their ligands in small‐for‐size graft

Jiang, W., Hu, M.-Z., Rao, J., Xu, X., Wang, X., & Kong, L. (2010) · Hepatology Research · doi:10.1111/j.1872-034x.2009.00603.x · Cited by 16

In vitro evaluation of defined oligosaccharide fractions in an equine model of inflammation

Vendrig, J. C., Coffeng, L. E., & Fink‐Gremmels, J. (2013) · BMC Veterinary Research · doi:10.1186/1746-6148-9-147 · Cited by 16

Thinking Outside the Cell: A Key Role for Hyaluronan in the Pathogenesis of Human Type 1 Diabetes

Bogdani, M. (2016) · Diabetes · doi:10.2337/db15-1750 · Cited by 18

Impact of refractive index increment on the determination of molecular weight of hyaluronic acid by muti-angle laser light-scattering technique

Han, Y. J., Li, D., Li, D., Chen, W., ShuE, M., Chen, Y., & Chai, J. (2020) · Scientific Reports · doi:10.1038/s41598-020-58992-7 · Cited by 16

Hyaluronan oligosaccharides perturb lymphocyte slow rolling on brain vascular endothelial cells: Implications for inflammatory demyelinating disease

Winkler, C. W., Foster, S. C., Itakura, A., Matsumoto, S. G., Asari, A., McCarty, O. J. T., & Sherman, L. S. (2013) · Matrix Biology · doi:10.1016/j.matbio.2013.01.002 · Cited by 16

Dehydroepiandrosterone: Molecular mechanisms and therapeutic implications in osteoarthritis

Huang, K., & Wu, L. (2018) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2018.05.004 · Cited by 16

Fibrin fragment E potentiates TGF-β-induced myofibroblast activation and recruitment

Fuchs, P. Ö., Calitz, C., Pavlović, N., Binet, F., Solbak, S. M. Ø., Danielson, U. H., Kreuger, J., Heindryckx, F., & Gerwins, P. (2020) · Cellular Signalling · doi:10.1016/j.cellsig.2020.109661 · Cited by 16

Functional Genomics of Lung Disease

Whitsett, J. A., Bachurski, C. J., Barnes, K. C., Bunn, P. A., Case, L. M., Cook, D. N., Crooks, D. M., Duncan, M. W., Dwyer‐Nield, L. D., Elston, R. C., et al. (2004) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2004-0071su · Cited by 16

TLR2 in murine atherosclerosis

Tobias, P. S., & Curtiss, L. K. (2007) · Seminars in Immunopathology · doi:10.1007/s00281-007-0102-3 · Cited by 16

Innate and adaptive autoimmunity in type 1 diabetes

Morran, M. P., McInerney, M. F., & Pietropaolo, M. (2008) · Pediatric Diabetes · doi:10.1111/j.1399-5448.2007.00334.x · Cited by 16

TSG6 hyaluronan matrix remodeling dampens the inflammatory response during colitis

Albtoush, N., Queisser, K. A., Zawerton, A., Lauer, M. E., Beswick, E. J., & Petrey, A. C. (2023) · Matrix Biology · doi:10.1016/j.matbio.2023.06.007 · Cited by 15

Post-Hyaluronic Acid Recurrent Eyelid Edema: Pathophysiologic Mechanisms and a Proposed Treatment Protocol

Karlin, J. N., Vranis, N. M., Dayan, E., & Parsa, K. (2023) · Aesthetic Surgery Journal Open Forum · doi:10.1093/asjof/ojad102 · Cited by 17

NAVIGATING THE LANDSCAPE OF ADJUVANTS FOR SUBUNIT VACCINES: RECENT ADVANCES AND FUTURE PERSPECTIVES

Orosco, F. L., & Espiritu, L. (2024) · International Journal of Applied Pharmaceutics · doi:10.22159/ijap.2024v16i1.49563 · Cited by 15

ZnO Nanoparticles as Potent Inducers of Dermal Immunosuppression in Contact Hypersensitivity in Mice

Wang, S., Ilves, M., Mäenpää, K., Zhao, L., El-Nezami, H. S., Karisola, P., & Alenius, H. T. (2024) · ACS Nano · doi:10.1021/acsnano.4c04270 · Cited by 16

Biomarkers of primary open-angle glaucoma

Knepper, P. A., Samples, J. R., & Yue, B. Y. (2010) · Expert Review of Ophthalmology · doi:10.1586/eop.10.73 · Cited by 15

Suppression of Ischemia-Induced Hippocampal Pyramidal Neuron Death by Hyaluronan Tetrasaccharide through Inhibition of Toll-Like Receptor 2 Signaling Pathway

Sunabori, T., Koike, M., Asari, A., Oonuki, Y., & Uchiyama, Y. (2016) · American Journal Of Pathology · doi:10.1016/j.ajpath.2016.03.016 · Cited by 15

Mycosporine-like amino acids stimulate hyaluronan secretion by up-regulating hyaluronan synthase 2 via activation of the p38/MSK1/CREB/c-Fos/AP-1 axis

Terazawa, S., Nakano, M., Yamamoto, A., & Imokawa, G. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.011139 · Cited by 15

A novel nano delivery system targeting different stages of osteoclasts

Zhang, B., Zhao, J., Yan, H., Zhao, Y., Tian, H., Cao, W. F., Wang, R. L., Jin, J., Chen, Y., Yang, C., et al. (2022) · Biomaterials Science · doi:10.1039/d2bm00076h · Cited by 16

Increased hyaluronan levels and decreased dendritic cell activation are associated with tumor invasion in murine lymphoma cell lines

Russo, R. I. C., Ernst, G., Lompardía, S. L., Blanco, G. A. C., Álvarez, É., García, M. G., & Hajos, S. E. (2011) · Immunobiology · doi:10.1016/j.imbio.2011.12.006 · Cited by 15

Expression of pattern recognition receptors in porcine uterine epithelial cells in vivo and in culture

Hamonic, G., Pasternak, J. A., Forsberg, N. M., Käser, T., & Wilson, H. L. (2018) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2018.06.006 · Cited by 15

Role of Toll-like receptor 4 in the inflammation reaction surrounding silicone prosthesis

Auquit-Auckbur, I., Caillot, F., Arnoult, C., et al. (2011) · Acta Biomaterialia · doi:10.1016/j.actbio.2011.01.030 · Cited by 15

Microbes and their products—physiological effects upon mammalian mucosa

Viswanathan, V. K. (2004) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2003.09.005 · Cited by 15

What do we know about Toll-Like Receptors Involvement in Gout Arthritis?

Silva, C. R., Saraiva, A. L., Rossato, M. F., Trevisan, G., & Oliveira, S. M. (2022) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530322666220523145728 · Cited by 16

The role of immune system in atherosclerosis: Molecular mechanisms, controversies, and future possibilities

Zhang, T., Pang, C., Xu, M., Zhao, Q., Hu, Z., Jiang, X., & Guo, M. (2024) · Human Immunology · doi:10.1016/j.humimm.2024.110765 · Cited by 14

The Identity of Innate Immune Activators in Organ Transplantation: Origins from Within or Exterior to the Host?

Goldstein, D. R. (2007) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2007.01851.x · Cited by 14

Cytokine Binding by Polysaccharide−Antibody Conjugates

Sun, L. T., Buchholz, K. S., Lotze, M. T., & Washburn, N. R. (2010) · Molecular Pharmaceutics · doi:10.1021/mp100150z · Cited by 14

Toll-like Receptor 4 Mediates the Inflammatory Responses and Matrix Protein Remodeling in Remote Non-Ischemic Myocardium in a Mouse Model of Myocardial Ischemia and Reperfusion

Zhai, Y., Ao, L., Cleveland, J. C., Zeng, Q., Reece, T. B., Fullerton, D. A., & Meng, X. (2015) · PLoS ONE · doi:10.1371/journal.pone.0121853 · Cited by 14

Lack of association between Toll-like receptor 4 gene polymorphisms and giant cell arteritis

Álvarez‐Rodríguez, L., López‐Hoyos, M., Beares, I., et al. (2011) · Lara D. Veeken · doi:10.1093/rheumatology/ker168 · Cited by 14

Control of autoimmune inflammation using liposomes to deliver positive allosteric modulators of metabotropic glutamate receptors

Gammon, J. M., Adapa, A. R., & Jewell, C. M. (2017) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.36151 · Cited by 14

Increase in hyaluronic acid degradation decreases the expression of estrogen receptor alpha in MCF7 breast cancer cell line

Hanoux, V., Eguida, J., Fleurot, E., et al. (2018) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2018.05.008 · Cited by 14

Role of Toll-like receptors in microbiota-associated gastrointestinal cancer metastasis

Ding, H., Lu, Q., & Li, W. (2013) · Journal of Cancer Research and Therapeutics · doi:10.4103/0973-1482.122509 · Cited by 14

WILL THE REAL HYALURONAN PLEASE STAND UP

Bucci, L. R. (2006) · Cited by 14

Inhibition of HA Synthase 3 mRNA Expression, with a Phosphodiesterase 3 Inhibitor, Blocks Lung Injury in a Septic Ventilated Rat Model

Hicham Mrabat, A., Beagle, J., Zhao, H., et al. (2009) · Lung · doi:10.1007/s00408-009-9157-3 · Cited by 14

Hyaluronic Acid in Liver Fibrosis: Role in Inflammation, Tissue Remodeling, and Disease Progression

Rojano-Alfonso, C., López‐Vicario, C., Romero-Grimaldo, B., Contreras, B. J., Clària, J., & Titos, E. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262010139 · Cited by 14

Pattern recognition receptors and their nano-adjuvants for cancer immunotherapy

Li, Z., Rana, I., Park, G. T., Lee, J., Park, C. E., & Nam, J. (2023) · Journal of Pharmaceutical Investigation · doi:10.1007/s40005-023-00633-y · Cited by 14

Novel synthetic gluco‐disaccharide RSCL‐0409 – a lipopolysaccharide‐induced Toll‐like receptor‐mediated signalling antagonist

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