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Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

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PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo

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MD-2, a Molecule that Confers Lipopolysaccharide Responsiveness on Toll-like Receptor 4

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Cutting Edge: Heat Shock Protein 60 Is a Putative Endogenous Ligand of the Toll-Like Receptor-4 Complex

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Toll-like Receptor 2 Functions as a Pattern Recognition Receptor for Diverse Bacterial Products*

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Low molecular weight hyaluronan preconditioning of tumor-pulsed dendritic cells increases their migratory ability and induces immunity against murine colorectal carcinoma

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Antimicrobial activity of novel mouthrinses against planktonic cells and biofilms of pathogenic microorganisms

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Modulation of pro-inflammatory activation of monocytes and dendritic cells by aza-bis-phosphonate dendrimer as an experimental therapeutic agent

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Toll-like receptors: a new target in rheumatoid arthritis?

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Modified High-Molecular-Weight Hyaluronan Promotes Allergen-Specific Immune Tolerance

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Understanding the Role of Innate Immunity in the Response to Intracortical Microelectrodes

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Involvement of hyaluronan in epidermal Langerhans cell maturation and migration in vivo

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Up-regulation of cell surface Toll-like receptor 4-MD2 expression on dendritic epidermal T cells after the emigration from epidermis during cutaneous inflammation

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Endogenous danger signals trigger hepatic ischemia/reperfusion injury through toll-like receptor 4/nuclear factor-kappa B pathway

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Questioning Current Concepts in Acute Pancreatitis: Endotoxin Contamination of Porcine Pancreatic Elastase Is Responsible for Experimental Pancreatitis-Associated Distant Organ Failure

Geisler, F., Algül, H., Riemann, M., & Schmid, R. M. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.10.6431 · Cited by 27

Innate immunity and cancer therapy

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Hydrolysis of Hyaluronic Acid in Lymphedematous Tissue Alleviates Fibrogenesis via TH1 Cell-Mediated Cytokine Expression

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Liver dysfunction after lung recruitment manoeuvres during pressure-controlled ventilation in experimental acute respiratory distress

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Modulation of toll-like receptor function has therapeutic potential in autoimmune disease

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Damage-associated molecular patterns and their receptors in upper airway pathologies

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Toll-like receptors in lymphoid malignancies: Double-edged sword

Harsini, S., Beigy, M., Sabagh, M. A., & Rezaei, N. (2013) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2013.08.010 · Cited by 27

The Tumor/Immune Interface: Clinical Evidence of Cancer Immunosurveillance, Immunoediting and Immunosubversion

Block, M. S., & Markovic, S. N. (2009) · American Journal of Immunology · doi:10.3844/ajisp.2009.29.49 · Cited by 29

The Role of Hyaluronan and CD44 in the Pathogenesis of Lupus Nephritis

Yung, S., & Chan, T. M. (2012) · Autoimmune Diseases · doi:10.1155/2012/207190 · Cited by 28

Novel regulators of cardiac inflammation: Matricellular proteins expand their repertoire

Rienks, M., & Papageorgiou, A. (2016) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2016.01.008 · Cited by 29

Rho proteins are negative regulators of TLR2, TLR3, and TLR4 signaling in astrocytes

Borysiewicz, E., Fil, D., & Konat, G. W. (2008) · Journal of Neuroscience Research · doi:10.1002/jnr.21968 · Cited by 28

Role of Innate Immunity in Initiation and Progression of Osteoarthritis, with Emphasis on Horses

Estrada-McDermott, J. M., Pezzanite, L. M., Goodrich, L. R., Santangelo, K. S., Chow, L., DOW, S. W., & Wheat, W. H. (2021) · Animals · doi:10.3390/ani11113247 · Cited by 30

Design Strategies for Hyaluronic Acid-based Drug Delivery Systems in Cancer Immunotherapy

Rodella, G., Véronique Préat, A., Gallez, B., & Malfanti, A. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.113784 · Cited by 28

TLR9-Dependent and Independent Pathways Drive Activation of the Immune System by Propionibacterium Acnes

Tchaptchet, S., Gumenscheimer, M., Kalis, C., Freudenberg, N., Hölscher, C., Kirschning, C. J., Lamers, M. C., Galanos, C., & Freudenberg, M. A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039155 · Cited by 29

Lack of association of TLR4 gene Asp299Gly and Thr399Ile polymorphisms with rheumatoid arthritis in Chinese Han population of Yunnan Province

Zheng, B., Li, Q., Wei, C., et al. (2010) · Rheumatology International · doi:10.1007/s00296-010-1400-y · Cited by 27

Interferon-Beta, a Decisive Factor in Angiogenesis and Arteriogenesis

Yıldırım, C., Nieuwenhuis, S., Teunissen, P. F. A., et al. (2015) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2014.0184 · Cited by 27

Nonmicrobial Activation of TLRs Controls Intestinal Growth, Wound Repair, and Radioprotection

Stenson, W. F., & Ciorba, M. A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.617510 · Cited by 26

When the allergy alarm bells toll: The role of Toll-like receptors in allergic diseases and treatment

Wenger, M., Grosse-Kathoefer, S., Kraiem, A., Pelamatti, E., Nunes, N. N. D. S., Pointner, L., & Aglas, L. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1204025 · Cited by 31

TLR Cross-Talk Mechanism of Hemorrhagic Shock-Primed Pulmonary Neutrophil Infiltration

Fan, J. (2009) · The Open Critical Care Medicine Journal · doi:10.2174/1874828700902010001 · Cited by 25

Low Molecular Weight Hyaluronan-Pulsed Human Dendritic Cells Showed Increased Migration Capacity and Induced Resistance to Tumor Chemoattraction

Rizzo, M., Bayo, J., Piccioni, F., Malvicini, M., Fiore, E. J., Peixoto, E., García, M. G., Aquino, J. B., Campaña, A. G., Podestá, G., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0107944 · Cited by 26

Mechanistic insights into cellular immunity of chondroitin sulfate A and its zwitterionic N-deacetylated derivatives

Zhang, W., Sun, F., Niu, H., Wang, Q., & Duan, J. (2015) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2015.01.059 · Cited by 27

Heterozygous Thr 135 Ala polymorphism at leucine-rich repeat (LRR) in genomic DNA of toll-like receptor 4 in patients with poorly-differentiated gastric adenocarcinomas

Ohara, T., Morishita, T., Suzuki, H., et al. (2006) · International Journal of Molecular Medicine · doi:10.3892/ijmm.18.1.59 · Cited by 26

Bioengineered hyaluronic acid elicited a nonantigenic T cell activation: Implications from cosmetic medicine and surgery to nanomedicine

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Self-adjuvanted hyaluronate – antigenic peptide conjugate for transdermal treatment of muscular dystrophy

Kong, W. H., Sung, D. K., Kim, H., Yang, J., Ieronimakis, N. M., Kim, K. S., Lee, J., Kim, D., Yun, S. H., & Hahn, S. K. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.12.007 · Cited by 27

Innate immune recognition receptors and damage-associated molecular patterns in plaque inflammation

Lundberg, A. M., & Yan, Z.-Q. (2011) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e32834ada80 · Cited by 26

Pep-1 as a Novel Probe for the In Situ Detection of Hyaluronan

Zmolik, J. M., & Mummert, M. E. (2005) · Journal of Histochemistry & Cytochemistry · doi:10.1369/jhc.4a6491.2005 · Cited by 26

Toll-like receptor modulation: A novel therapeutic strategy in cardiovascular disease?

Katsargyris, Α., Klonaris, C. N., Bastounis, E., & Theocharis, S. E. (2008) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.12.11.1329 · Cited by 26

Lack of association of TLR4 polymorphisms with susceptibility to rheumatoid arthritis and ankylosing spondylitis: A meta-analysis

Xu, W., Liu, S., Pan, H., & Ye, D. (2012) · Joint Bone Spine · doi:10.1016/j.jbspin.2012.02.012 · Cited by 25

A modified flavonoid accelerates oligodendrocyte maturation and functional remyelination

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Hyaluronan/Diethylaminoethyl Chitosan Polyelectrolyte Complexes as Carriers for Improved Colistin Delivery

Dubashynskaya, N. V., Raik, S. V., Dubrovskii, Y. A., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168381 · Cited by 25

Hydroxyapatite-embedded levan composite hydrogel as an injectable dermal filler for considerable enhancement of biological efficacy

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Toll-Like Receptors in Peripheral Nerve Injury and Neuropathic Pain

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Murine Abortion is Associated with Enhanced Hyaluronan Expression and Abnormal Localization at the Fetomaternal Interface

Russo, R. I. C., García, M. G., Barrientos, G., Orsal, A. S., Viola, M., Moschansky, P., Ringel, F., Passi, A. G., Alaniz, L. D., HAJOS, S. E., et al. (2008) · Placenta · doi:10.1016/j.placenta.2008.10.013 · Cited by 24

Urinary Bladder Tissue Engineering Using Natural Scaffolds in a Porcine Model: Role of Toll-Like Receptors and Impact of Biomimetic Molecules

Evren, S., Loai, Y., Antoon, R., Islam, S. S., Yeger, H., Moore, K., Wong, K. K. W., Gorczynski, R. M., & Farhat, W. A. (2010) · Cells Tissues Organs · doi:10.1159/000317332 · Cited by 26

Association of TLR4 gene non-missense single nucleotide polymorphisms with rheumatoid arthritis in Chinese Han population

Yang, H., Wei, C., Li, Q., et al. (2012) · Rheumatology International · doi:10.1007/s00296-012-2536-8 · Cited by 25

Inhibition of Dendritic Cell Maturation by Group AStreptococcus

Cortés, G., & Wessels, M. R. (2009) · The Journal of Infectious Diseases · doi:10.1086/605696 · Cited by 27

Chemical or Drug Hypersensitivity: Is the Immune System Clearing the Danger?

Pallardy, M. J., & Bechara, R. (2017) · Toxicological Sciences · doi:10.1093/toxsci/kfx084 · Cited by 29

MiR-202-5p Promotes M2 Polarization in Allergic Rhinitis by Targeting MATN2

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Hyaluronan: From Biomimetic to Industrial Business Strategy

Murano, E., Perin, D., Khan, R., & Bergamin, M. (2011) · Natural Product Communications · doi:10.1177/1934578x1100600415 · Cited by 26

Modulation of hyaluronan signaling as a therapeutic target in human disease

Garantziotis, S. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107993 · Cited by 26

Hyaluronan breakdown by snake venom hyaluronidases: From toxins delivery to immunopathology

de França, F. S., & Tambourgi, D. V. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1125899 · Cited by 27

Review: N1-methyl-pseudouridine (m1Ψ): Friend or foe of cancer?

Rubio‐Casillas, A., Cowley, D., Raszek, M., Uversky, V. N., & Redwan, E. M. M. M. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.131427 · Cited by 27

Hantaan Virus Triggers TLR4-Dependent Innate Immune Responses

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Intermediate Molecular Mass Hyaluronan and CD44 Receptor Interactions Enhance Neutrophil Phagocytosis and IL-8 Production via p38- and ERK1/2-MAPK Signalling Pathways

Lu, C., Lin, C., Li, K., Shen, C., Wu, C.-H., Kuo, Y., Lin, T., Yu, C., & Hsieh, S. (2017) · Inflammation · doi:10.1007/s10753-017-0622-5 · Cited by 24

miR-122/SIRT1 axis regulates chondrocyte extracellular matrix degradation in osteoarthritis

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Specialised lipid mediators and their targets

Crean, D., & Godson, C. (2015) · Seminars in Immunology · doi:10.1016/j.smim.2015.05.002 · Cited by 25

Profibrotic Effect of Interleukin-18 in HK-2 Cells Is Dependent on Stimulation of the Toll-like Receptor 4 (TLR4) Promoter and Increased TLR4 Expression

Meldrum, K. K., Zhang, H., Hile, K. L., Moldower, L. L., Dong, Z., & Meldrum, D. R. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.402420 · Cited by 24

CD44 -- a sticky target for asthma

Rothenberg, M. E. (2003) · Journal of Clinical Investigation · doi:10.1172/jci18392 · Cited by 24

Pycnogenol, an extract from French maritime pine, suppresses Toll-like receptor 4-mediated expression of adipose differentiation-related protein in macrophages

Gu, J.-Q., Ikuyama, S., Wei, P. Y., et al. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90543.2008 · Cited by 24

Hyaluronan oligosaccharides modulate inflammatory response, NIS and thyreoglobulin expression in human thyrocytes

D’Ascola, A., Scuruchi, M., Ruggeri, R. M., et al. (2020) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2020.108598 · Cited by 23

Hyaluronic Acid-Glycine-Cholesterol Conjugate-Based Nanoemulsion as a Potent Vaccine Adjuvant for T Cell-Mediated Immunity

Lin, C.-A., Ho, H., Venkatesan, P., Huang, C., Cheng, Y.-J., Lin, Y.-H., Lin, H.-Y., Chen, T.-Y., Huang, M., & Lai, P. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13101569 · Cited by 24

Modulation of Cell-Cycle Progression by Hydrogen Peroxide-Mediated Cross-Linking and Degradation of Cell-Adhesive Hydrogels

Mubarok, W., Elvitigala, K. C. M. L., Nakahata, M., Kojima, M., & Sakai, S. (2022) · Cells · doi:10.3390/cells11050881 · Cited by 23

Hyaluronan-colistin conjugates: Synthesis, characterization, and prospects for medical applications

Dubashynskaya, N. V., Bokatyi, A. N., Gasilova, E. R., et al. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.06.080 · Cited by 23

Hyaluronan promotes intracellular ROS production and apoptosis in TNFα-stimulated neutrophils

Niemietz, I., & Brown, K. L. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1032469 · Cited by 25

Hyaluronan fragments as mediators of inflammation in allergic pulmonary disease

Ghosh, S., Hoselton, S. A., Dorsam, G. P., & Schuh, J. M. (2015) · Immunobiology · doi:10.1016/j.imbio.2014.12.005 · Cited by 24

Matrix proteoglycans as effector molecules for epithelial cell function

Frevert, C. W., & Sannes, P. L. (2005) · European Respiratory Review · doi:10.1183/09059180.05.00009703 · Cited by 23

Degradation of hyaluronic acid derived from tilapia eyeballs by a combinatorial method of microwave, hydrogen peroxide, and ascorbic acid

Chen, S., Chen, H., Gao, R., Li, L., Yang, X., Wu, Y., & Hu, X. (2015) · Polymer Degradation and Stability · doi:10.1016/j.polymdegradstab.2014.12.026 · Cited by 22

Modulation of innate and adaptive immune responses by arabinoxylans

Fadel, A., Plunkett, A., Li, W., Gyamfi, V. E. T., Nyaranga, R. R., Fadel, F., Dakak, S., Ranneh, Y., Salmon, Y., & Ashworth, J. (2017) · Journal of Food Biochemistry · doi:10.1111/jfbc.12473 · Cited by 23

Therapeutic Interventions Targeting Innate Immune Receptors: A Balancing Act

Cao, X., Cordova, A. F., & Li, L. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00716 · Cited by 24

Pattern recognition receptors in equine endotoxaemia and sepsis

Werners, A. H., & Bryant, C. E. (2012) · Equine Veterinary Journal · doi:10.1111/j.2042-3306.2012.00574.x · Cited by 25

Role of the microenvironment in immune responses to transplantation

Wrenshall, L. E. (2003) · Springer Seminars in Immunopathology · doi:10.1007/s00281-003-0138-y · Cited by 23

Inflammation and transplantation tolerance

Goldstein, D. R. (2011) · Seminars in Immunopathology · doi:10.1007/s00281-011-0251-2 · Cited by 23

Tissue destruction caused by cytotoxic T lymphocytes induces deletional tolerance

Parish, I. A., Waithman, J. C., Davey, G. M., Belz, G. T., Mintern, J. D., Kurts, C., Sutherland, R. M., Carbone, F., & Heath, W. R. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810427106 · Cited by 23

Do double-stranded RNA receptors play a role in preeclampsia?

Chatterjee, P., Weaver, L., Chiasson, V. L., Young, K. J., & Mitchell, B. M. (2011) · Placenta · doi:10.1016/j.placenta.2010.12.026 · Cited by 23

Immunology and genetics of tumour necrosis factor in allergic contact dermatitis

Dittmar, D., & Schuttelaar, M. L. A. (2017) · Contact Dermatitis · doi:10.1111/cod.12769 · Cited by 26

Circulating TNF-like protein 1A (TL1A) is elevated early in rheumatoid arthritis and depends on TNF

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MyD88 Is a Critical Regulator of Hematopoietic Cell-Mediated Neuroprotection Seen after Stroke

Downes, C., Wong, C. H. Y., Henley, K. J., Guio-Aguilar, P. L., Zhang, M., Ates, R., Mansell, A. S., Kile, B. T., & Crack, P. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057948 · Cited by 22

TOLL-LIKE RECEPTORS IN CHRONIC LYMPHOCYTIC LEUKEMIA

Muzio, M., Fonte, E., & Caligaris‐Cappio, F. (2012) · Mediterranean Journal of Hematology and Infectious Diseases · doi:10.4084/mjhid.2012.055 · Cited by 24

Fragmented hyaluronan has no alarmin function assessed in arthritis synovial fibroblast and chondrocyte cultures

Olsson, M., Bremer, L., Aulin, C., & Harris, H. E. (2018) · Innate Immunity · doi:10.1177/1753425918759590 · Cited by 22

Innate immunity in host-microbial interactions: Beyond B27 in the spondyloarthropathies

Pacheco‐Tena, C., Zhang, X., Stone, M., et al. (2002) · Current Opinion in Rheumatology · doi:10.1097/00002281-200207000-00007 · Cited by 22

Vα14 NKT cell-mediated anti-tumor responses and their clinical application

Seino, K., Fujii, S., Harada, M., et al. (2005) · Springer Seminars in Immunopathology · doi:10.1007/s00281-004-0194-y · Cited by 22

N-(2-hydroxy phenyl) acetamide: a novel suppressor of Toll-like receptors (TLR-2 and TLR-4) in adjuvant-induced arthritic rats

Perveen, K., Hanif, F., Jawed, H., Jamall, S., & Sımjee, S. U. (2014) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-014-2082-7 · Cited by 21

Knockdown of toll-like receptor 4 signaling pathways ameliorate bone graft rejection in a mouse model of allograft transplantation

Hsieh, J., Shen, P., Wu, P., Jou, I., Wu, C., Shiau, A., Wang, C., Chong, H., Chuang, S., Peng, J., et al. (2017) · Scientific Reports · doi:10.1038/srep46050 · Cited by 22

Toll-Like Receptor 4 on both Myeloid Cells and Dendritic Cells Is Required for Systemic Inflammation and Organ Damage after Hemorrhagic Shock with Tissue Trauma in Mice

Zettel, K. R., Korff, S., Zamora, R., Morelli, A. E., Darwiche, S. S., Loughran, P., Elson, G., Shang, L., Salgado-Pires, S., Scott, M. J., et al. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01672 · Cited by 21

Hyaluronic acid fragments evoke Kupffer cells via TLR4 signaling pathway

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