Oligosaccharides of Hyaluronan Activate Dendritic Cells via Toll-like Receptor 4

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

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PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo

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MD-2, a Molecule that Confers Lipopolysaccharide Responsiveness on Toll-like Receptor 4

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A family of human receptors structurally related to Drosophila Toll.

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Hyaluronan 1

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MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways.

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Cutting Edge: Heat Shock Protein 60 Is a Putative Endogenous Ligand of the Toll-Like Receptor-4 Complex

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Toll-like Receptor 2 Functions as a Pattern Recognition Receptor for Diverse Bacterial Products*

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Toll-Like Receptors in Spinal Cord Injury

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IL-17 induces the production of IL-16 in rheumatoid arthritis

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Salivary mucins induce a Toll-like receptor 4-mediated pro-inflammatory response in human submandibular salivary cells: are mucins involved in Sjögren’s syndrome?

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The immunological effect of hyaluronan in tumor angiogenesis

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Infrapatellar Fat Pad Stem Cells Responsiveness to Microenvironment in Osteoarthritis: From Morphology to Function

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Small fragments of hyaluronan are increased in individuals with obesity and contribute to low-grade inflammation through TLR-mediated activation of innate immune cells

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Reducing the Toll of Inflammatory Lung Disease

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Host antimicrobial proteins as endogenous immunomodulators

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A synthetic analog of α-galactosylceramide induces macrophage activation via the TLR4-signaling pathways

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Current knowledge of immunomodulation strategies for chronic skin wound repair

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Role of toll-like receptor 4 in diabetic retinopathy

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Superoxide Dismutase 3 Suppresses Hyaluronic Acid Fragments Mediated Skin Inflammation by Inhibition of Toll-Like Receptor 4 Signaling Pathway: Superoxide Dismutase 3 Inhibits Reactive Oxygen Species-Induced Trafficking of Toll-Like Receptor 4 to Lipid Rafts

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Metabolism and mechanisms of action of hyaluronan in human biology

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Toll-like receptor 4: A promising crossroads in the diagnosis and treatment of several pathologies

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Synthesis of Hyaluronic Acid Oligomers using Chemoselective and One-Pot Strategies

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Functional diversity of stem and progenitor cells with B‐lymphopoietic potential

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Cathelicidin Antimicrobial Peptides Inhibit Hyaluronan-Induced Cytokine Release and Modulate Chronic Allergic Dermatitis

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Increased Serum Pentraxin 3 in Patients with Systemic Sclerosis

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κ-Opioid receptor stimulation modulates TLR4/NF-κB signaling in the rat heart subjected to ischemia–reperfusion

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TLR4 Is a Negative Regulator in Noninfectious Lung Inflammation

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Postulates for validating TLR4 agonists

Manček‐Keber, M., & Jerala, R. (2014) · European Journal of Immunology · doi:10.1002/eji.201444462 · Cited by 51

Management of actinic cheilitis using diclofenac 3% gel: a report of six cases

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Regulatory T cells in microbial infection

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Lung Hyaluronasome: Involvement of Low Molecular Weight Ha (Lmw-Ha) in Innate Immunity

Hoarau, A., Polette, M., & Coraux, C. (2022) · Biomolecules · doi:10.3390/biom12050658 · Cited by 49

Glycosaminoglycans’ Ability to Promote Wound Healing: From Native Living Macromolecules to Artificial Biomaterials

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Pretreatment with soluble ST2 reduces warm hepatic ischemia/reperfusion injury

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Low molecular weight hyaluronic acid effects on murine macrophage nitric oxide production

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Damage-associated molecular patterns and their role as initiators of inflammatory and auto-immune signals in systemic lupus erythematosus

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4-Methylumbelliferyl glucuronide contributes to hyaluronan synthesis inhibition

Nagy, N., Gurevich, I., Kuipers, H. F., Ruppert, S. M., Marshall, P. L., Xie, B. J., Sun, W., Malkovskiy, A. V., Rajadas, J., Grandoch, M., et al. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.006166 · Cited by 47

Enhancement of dendritic cell-based vaccine potency by targeting antigen to endosomal/lysosomal compartments

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Toll-Like Receptors and Myocardial Ischemia/Reperfusion, Inflammation, and Injury

Kaczorowski, D. J., Nakao, A., McCurry, K. R., & Billiar, T. R. (2009) · Current Cardiology Reviews · doi:10.2174/157340309788970405 · Cited by 46

Hyaluronan mediates adhesion of metastatic colon carcinoma cells1

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CpG DNA in the Prevention and Treatment of Infections

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Sugars in the microenvironment: the sticky problem of HA turnover in tumors

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Gene expression and activity of cartilage degrading glycosidases in human rheumatoid arthritis and osteoarthritis synovial fibroblasts

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Interferon regulatory factor 3 deficiency leads to interleukin-17-mediated liver ischemia-reperfusion injury

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Hyaluronic acid in digestive cancers

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Epigallocatechin-3-gallate alleviates paraquat-induced acute lung injury and inhibits upregulation of toll-like receptors

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Tenascin C regulates multiple microglial functions involving TLR4 signaling and HDAC1

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Alteration of Polysaccharide Size Distribution of a Vertebrate Hyaluronan Synthase by Mutation

Pummill, P. E., & DeAngelis, P. L. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301097200 · Cited by 47

Carbohydrate Immune Adjuvants in Subunit Vaccines

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Double‐stranded RNA mediates interferon regulatory factor 3 activation and interleukin‐6 production by engaging Toll‐like receptor 3 in human brain astrocytes

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Toll‐like receptors in rheumatic diseases: Are we paying a high price for our defense against bugs?

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Degrading products of chondroitin sulfate can induce hypertrophy-like changes and MMP-13/ADAMTS5 production in chondrocytes

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Polymyxin B Inadequately Quenches the Effects of Contaminating Lipopolysaccharide on Murine Dendritic Cells

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Toll-Like Receptor-4 Deficiency Enhances Repair of UVR-Induced Cutaneous DNA Damage by Nucleotide Excision Repair Mechanism

Ahmad, I., Simanyi, E., Guroji, P., Tamimi, I. A., delaRosa, H. J., Nagar, A., Nagar, P., Katiyar, S. K., Elmets, C. A., & Yusuf, N. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.530 · Cited by 43

The Ectodomain of the Toll-like Receptor 4 Prevents Constitutive Receptor Activation

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Nonmetal Haptens Induce ATP Release from Keratinocytes through Opening of Pannexin Hemichannels by Reactive Oxygen Species

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Toll-like receptors (TLRs) and immune disorders

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Toll-like receptor 5 activation promotes migration and invasion of salivary gland adenocarcinoma

Park, J., Yoon, H., Kim, D., Kim, S., Ahn, S., & Yoon, J. H. (2010) · Journal of Oral Pathology and Medicine · doi:10.1111/j.1600-0714.2010.00929.x · Cited by 44

The Mal/TIRAP S180L and TLR4 G299D polymorphisms are not associated with susceptibility to, or severity of, rheumatoid arthritis

Sheedy, F. J., Μαρίνου, Ι., O’Neill, L. A. J., & Wilson, A. G. (2008) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2007.083337 · Cited by 44

NF-κB Activation Mediates the Cross-talk between Extracellular Matrix and Interferon-γ (IFN-γ) Leading to Enhanced Monokine Induced by IFN-γ (MIG) Expression in Macrophages

Horton, M. R., Boodoo, S., & Powell, J. D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206007200 · Cited by 44

Effects of molecular weights on the bioactivity of hyaluronic acid: A review

Wang, X., Liu, X., Li, C., Li, J., Qiu, M., Wang, Y., & Han, W. (2025) · Carbohydrate Research · doi:10.1016/j.carres.2025.109472 · Cited by 45

The pharmacokinetics and dosing of oral 4-methylumbelliferone for inhibition of hyaluronan synthesis in mice

Kuipers, H. F., Nagy, N., Ruppert, S. M., Sunkari, V. G., Marshall, P. L., Gebe, J. A., Ishak, H. D., Keswani, S. G., Bollyky, J., Frymoyer, A. R., et al. (2016) · Clinical & Experimental Immunology · doi:10.1111/cei.12815 · Cited by 47

Advances and Advantages of Nanomedicine in the Pharmacological Targeting of Hyaluronan-CD44 Interactions and Signaling in Cancer

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Hyaluronan Synthesis Is Required for IL-2-Mediated T Cell Proliferation

Mahaffey, C. L., & Mummert, M. E. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.12.8191 · Cited by 43

Toll like receptors and acute allograft rejection

Goldstein, D. R. (2006) · Transplant Immunology · doi:10.1016/j.trim.2006.09.012 · Cited by 43

Dendritic Cells Transduced with Tumor-Associated Antigen Gene Elicit Potent Therapeutic Antitumor Immunity: Comparison with Immunodominant Peptide-Pulsed DCs

Nakamura, M., Iwahashi, M., Nakamori, M., et al. (2005) · Oncology · doi:10.1159/000086770 · Cited by 43

Hyaluronan is a natural and effective immunological adjuvant for protein-based vaccines

Pietà, A. D., Carpanese, D., Grigoletto, A., Tosi, A., Santa, S. D., Pedersen, G. K., Christensen, D., Meléndez‐Alafort, L., Barbieri, V., Benedictis, P. D., et al. (2021) · Cellular and Molecular Immunology · doi:10.1038/s41423-021-00667-y · Cited by 45

Transcriptional control of metabolism by interferon regulatory factors

Ahmad, Z., Kahloan, W., & Rosen, E. D. (2024) · Nature Reviews Endocrinology · doi:10.1038/s41574-024-00990-0 · Cited by 45

Lipopolysaccharide hyporesponsiveness as a risk factor for intensive care unit hospitalization in infants with respiratory syncitial virus bronchiolitis

Mandelberg, A., Tal, G., Naugolni, L., Cesar, K., Oron, A., Houri, S., Gilad, E., & Somekh, E. (2006) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2006.03030.x · Cited by 41

Chemically Modified N-Acylated Hyaluronan Fragments Modulate Proinflammatory Cytokine Production by Stimulated Human Macrophages

Babasola, I. O., Rees-Milton, K. J., Bebe, S., Wang, J., & Anastassiades, T. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.515783 · Cited by 44

Combination stem cell therapy for heart failure

Ichim, T. E., Solano, F., Lara, F., Rodriguez, J., Cristea, O., Minev, B., Ramos, F., Woods, E. J., Murphy, M. P., Alexandrescu, D. T., et al. (2010) · International Archives of Medicine · doi:10.1186/1755-7682-3-5 · Cited by 43

An update review on recent skin fillers

Cheng, L.-Y., Sun, X.-M., Tang, M.-Y., Jin, R., Cui, W.-G., & Zhang, Y.-G. (2016) · Plastic and Aesthetic Research · doi:10.20517/2347-9264.2015.124 · Cited by 43

The influence of glycosaminoglycans on IL-8-mediated functions of neutrophils

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Activation of the innate immune system by the endogenous ligand hyaluronan

Shirali, A. C., & Goldstein, D. R. (2008) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0b013e3282f3df04 · Cited by 44

Specific immune response to HBsAg is enhanced by β-glucan oligosaccharide containing an α-(1→3)-linked bond and biased towards M2/Th2

Dong, S.-F., Chen, J., Zhang, W., et al. (2007) · International Immunopharmacology · doi:10.1016/j.intimp.2007.01.004 · Cited by 42

The enzymatic degradation of hyaluronan is associated with disease progression in experimental pulmonary hypertension

Ormiston, M. L., Slaughter, G., Deng, Y., Stewart, D. J., & Courtman, D. W. (2009) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00097.2009 · Cited by 43

Physiopathology of natural auto-antibodies: The case for regulation

Zelenay, S., Moraes‐Fontes, M. F., Fesel, C., Demengeot, J., & Coutinho, A. (2007) · Journal of Autoimmunity · doi:10.1016/j.jaut.2007.07.011 · Cited by 42

Extravascular Red Blood Cells and Hemoglobin Promote Tumor Growth and Therapeutic Resistance as Endogenous Danger Signals

Yin, T., He, S., Liu, X., Jiang, W., Ye, T., Lin, Z., Sang, Y., Su, C., Wan, Y., Shen, G., et al. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1400643 · Cited by 42

Controversial role of toll-like receptors in acute pancreatitis

Vaz, J. (2013) · World Journal of Gastroenterology · doi:10.3748/wjg.v19.i5.616 · Cited by 41

Toll-Like Receptor 3 Increases Allergic and Irritant Contact Dermatitis

Nakamura, N., Tamagawa‐Mineoka, R., Ueta, M., Kinoshita, S., & Katoh, N. (2014) · Journal of Investigative Dermatology · doi:10.1038/jid.2014.402 · Cited by 41

Treating atherosclerosis: the potential of Toll-like receptors as therapeutic targets

Cole, J. E., Mitra, A. T., & Monaco, C. G. (2010) · Expert Review of Cardiovascular Therapy · doi:10.1586/erc.10.149 · Cited by 40

Assembly and Immunological Processing of Polyelectrolyte Multilayers Composed of Antigens and Adjuvants

Chiu, Y.-C., Gammon, J. M., Andorko, J. I., Tostanoski, L. H., & Jewell, C. M. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b06275 · Cited by 41

Impact of molecular weight on the intrinsic immunogenic activity of poly(beta amino esters)

Andorko, J. I., Pineault, K. G., & Jewell, C. M. (2016) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.35970 · Cited by 41

Rarity of TLR4 Asp299Gly and Thr399Ile Polymorphisms in the Korean Population

Kim, Y. S., Hwang, Y. J., Kim, S., et al. (2008) · Yonsei Medical Journal · doi:10.3349/ymj.2008.49.1.58 · Cited by 41

Toll-like receptor 4 induced FcγR expression potentiates early onset of joint inflammation and cartilage destruction during immune complex arthritis: Toll-like receptor 4 largely regulates FcγR expression by interleukin 10

van Lent, P. L. E. M., Blom, A. B., Grevers, L., Sloetjes, A. W., & van den Berg, W. B. (2006) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2006.057471 · Cited by 41

Natural vs Synthetic Polymers: How Do They Communicate with Cells for Skin Regeneration—A Review

Elango, J., Zamora‐Ledezma, C., & de Val, J. E. M. S. (2023) · Journal of Composites Science · doi:10.3390/jcs7090385 · Cited by 41

Innate and adaptive immune responses in tissue engineering

Sefton, M. V., Babensee, J. E., & Woodhouse, K. A. (2008) · Seminars in Immunology · doi:10.1016/j.smim.2007.12.008 · Cited by 40

The stimulation of adenosine 2A receptor reduces inflammatory response in mouse articular chondrocytes treated with hyaluronan oligosaccharides

Campo, G. M., Avenoso, A., D’Ascola, A., Prestipino, V., Scuruchi, M., Nastasi, G., Calatroni, A., & Campo, S. (2012) · Matrix Biology · doi:10.1016/j.matbio.2012.07.001 · Cited by 41

Prevention of infectious diseases in older adults through immunization: the challenge of the senescent immune response

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Hyaluronan interactions with innate immunity in lung biology

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