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Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

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PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo

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Toll-like receptors in the induction of the innate immune response

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MD-2, a Molecule that Confers Lipopolysaccharide Responsiveness on Toll-like Receptor 4

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A family of human receptors structurally related to Drosophila Toll.

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Hyaluronan 1

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MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways.

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Cutting Edge: Heat Shock Protein 60 Is a Putative Endogenous Ligand of the Toll-Like Receptor-4 Complex

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Toll-like Receptor 2 Functions as a Pattern Recognition Receptor for Diverse Bacterial Products*

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ECM remodelling in IBD: innocent bystander or partner in crime? The emerging role of extracellular molecular events in sustaining intestinal inflammation

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Amplification of the response to Toll‐like receptor ligands by prolonged exposure to interleukin‐6 in mice: Implication for the pathogenesis of macrophage activation syndrome

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Dysregulated Toll-like receptor expression and signaling in bone marrow-derived macrophages at the onset of diabetes in the non-obese diabetic mouse

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Tumor necrosis factor α blockade treatment down‐modulates the increased systemic and local expression of toll‐like receptor 2 and toll‐like receptor 4 in spondylarthropathy

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Papillomavirus-Like Particles Stimulate Murine Bone Marrow-Derived Dendritic Cells To Produce Alpha Interferon and Th1 Immune Responses via MyD88

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Engagement of CD44 by hyaluronan suppresses TLR4 signaling and the septic response to LPS

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Neural injury following stroke: are Toll‐like receptors the link between the immune system and the CNS?

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Toll‐like Receptors at the Maternal‐Fetal Interface in Normal Pregnancy and Pregnancy Complications

Koga, K., Izumi, G., Mor, G., Fujii, T., & Osuga, Y. (2014) · American Journal of Reproductive Immunology · doi:10.1111/aji.12258 · Cited by 122

Toll-like receptors as therapeutic targets for autoimmune connective tissue diseases

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Activation of the MAPK, ERK, following Leishmania amazonensis Infection of Macrophages

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Wound Healing Versus Regeneration: Role of the Tissue Environment in Regenerative Medicine

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Immunologic Roles of Hyaluronan

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Extracellular Matrix Composition Reveals Complex and Dynamic Stromal-Epithelial Interactions in the Mammary Gland

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Differential Effect of Transforming Growth Factor β (TGF-β) on the Genes Encoding Hyaluronan Synthases and Utilization of the p38 MAPK Pathway in TGF-β-induced Hyaluronan Synthase 1 Activation

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Early events in the recognition of danger signals after tissue injury

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The role of Toll‐like receptors in CNS response to microbial challenge

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The role of toll-like receptors in acute and chronic lung inflammation

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Characterization of IL-17 + Interphotoreceptor Retinoid-Binding Protein-Specific T Cells in Experimental Autoimmune Uveitis

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TLR ligands and cytokines induce CXCR3 ligands in endothelial cells: enhanced CXCL9 in autoimmune arthritis

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Increasing numbers of hepatic dendritic cells promote HMGB1-mediated ischemia-reperfusion injury

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Role of Toll-like receptor-4 in renal graft ischemia-reperfusion injury

Zhao, H., Perez, J. S., Lu, K., George, A. J. T., & Ma, D. (2014) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00469.2013 · Cited by 120

Cutting Edge: High-Mobility Group Box 1 Preconditioning Protects against Liver Ischemia-Reperfusion Injury

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Toll-like receptors in cardiovascular diseases

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Hyaluronan Synthase 1: A Mysterious Enzyme with Unexpected Functions

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Epithelia: lymphocyte interactions in the gut

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Association of polymorphisms in TLR genes and in genes of the Toll-like receptor signaling pathway with cancer risk

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Hyaluronan and Reactive Oxygen Species Signaling—Novel Cues from the Matrix?

Berdiaki, A., Neagu, M. T., Spyridaki, I., Николаевич, К. А., Pérez, S., & Nikitovic, D. (2023) · Antioxidants · doi:10.3390/antiox12040824 · Cited by 127

Toll-like receptors 2 and 4: initiators of non-septic inflammation in critical care medicine?

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Cancer Microenvironment and Inflammation: Role of Hyaluronan

Nikitovic, D., Tzardi, M. N., Berdiaki, A., Tsatsakis, A. M., & Tzanakakis, G. N. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00169 · Cited by 114

Toll-Like Receptor 4 Mediates Lung Ischemia-Reperfusion Injury

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Hyaluronan – magic glue for the regulation of the immune response?

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Acute ischemic injury to the renal microvasculature in human kidney transplantation

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Toll-Like Receptor-4 Signaling Mediates Hepatic Injury and Systemic Inflammation in Hemorrhagic Shock

Prince, J. M., Levy, R. M., Yang, R., Mollen, K. P., Fink, M. P., Yoram Vodovotz, B., & Billiar, T. R. (2006) · Journal of the American College of Surgeons · doi:10.1016/j.jamcollsurg.2005.11.021 · Cited by 112

Bench-to-bedside review: the role of glycosaminoglycans in respiratory disease.

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Distinct responses of monocytes to Toll-like receptor ligands and inflammatory cytokines

Farina, C. (2004) · International Immunology · doi:10.1093/intimm/dxh083 · Cited by 116

Fungal glycans and the innate immune recognition

Barreto‐Bergter, E., & Figueiredo, R. T. (2014) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2014.00145 · Cited by 115

Hyaluronan and Hyaluronan-Binding Proteins Accumulate in Both Human Type 1 Diabetic Islets and Lymphoid Tissues and Associate With Inflammatory Cells in Insulitis

Bogdani, M., Johnson, P. Y., Potter‐Perigo, S., Nagy, N., Day, A. J., Bollyky, P. L., & Wight, T. N. (2014) · Diabetes · doi:10.2337/db13-1658 · Cited by 112

The Endothelial Glycocalyx: A Possible Therapeutic Target in Cardiovascular Disorders

Milusev, A., Rieben, R., & Sorvillo, N. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.897087 · Cited by 127

Chemotaxis towards hyaluronan is dependent on CD44 expression and modulated by cell type variation in CD44-hyaluronan binding

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Osteoimmunology of Oral and Maxillofacial Diseases: Translational Applications Based on Biological Mechanisms

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T Lymphocyte-Mediated Immune Responses to Chemical Haptens and Metal Ions: Implications for Allergic and Autoimmune Disease

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The Mechanisms and Physiological Relevance of Glycocalyx Degradation in Hepatic Ischemia/Reperfusion Injury

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Digestion products of the PH20 hyaluronidase inhibit remyelination

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Group B Streptococcus Evades Host Immunity by Degrading Hyaluronan

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Recent advances in hyaluronic acid-based nanomedicines: Preparation and application in cancer therapy

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Extracellular Matrix Components and Mechanosensing Pathways in Health and Disease

Berdiaki, A., Neagu, M. T., Tzanakakis, P., Spyridaki, I., Pérez, S., & Nikitovic, D. (2024) · Biomolecules · doi:10.3390/biom14091186 · Cited by 117

“Dirty little secrets”—Endotoxin contamination of recombinant proteins

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Matrix Regulation of Lung Injury, Inflammation, and Repair: The Role of Innate Immunity

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Low Molecular Weight Hyaluronan Activates Cytosolic Phospholipase A2α and Eicosanoid Production in Monocytes and Macrophages

Sokołowska, M., Chen, L. Y., Eberlein, M. H., Martínez‐Antón, A., Liu, Y., Alsaaty, S., Qi, H.-Y., Logun, C., Horton, M. R., & Shelhamer, J. H. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.515106 · Cited by 111

Thematic review series: The Immune System and Atherogenesis. Paying the price for pathogen protection: toll receptors in atherogenesis

Tobias, P. S., & Curtiss, L. K. (2005) · Journal of Lipid Research · doi:10.1194/jlr.r400015-jlr200 · Cited by 108

CD19, a Response Regulator of B Lymphocytes, Regulates Wound Healing through Hyaluronan-Induced TLR4 Signaling

Iwata, Y., Yoshizaki, A., Komura, K., Shimizu, K., Ogawa, F., Hara, T., Muroi, E., Bae, S., Takenaka, M., Yukami, T., et al. (2009) · The American Journal of Pathology · doi:10.2353/ajpath.2009.080355 · Cited by 107

Dual Role of Toll-Like Receptors in Asthma and Chronic Obstructive Pulmonary Disease

Bezemer, G. F. G., Sagar, S., van Bergenhenegouwen, J., Georgiou, N., Garssen, J., Kraneveld, A. D., & Folkerts, G. (2012) · Pharmacological Reviews · doi:10.1124/pr.111.004622 · Cited by 110

Hyaluronan Modulation Impacts Staphylococcus aureus Biofilm Infection

Ibberson, C. B., Parlet, C. P., Kwiecinski, J. M., Crosby, H. A., Meyerholz, D. K., & Horswill, A. R. (2016) · Infection and Immunity · doi:10.1128/iai.01418-15 · Cited by 109

Hyaluronan inhibits osteoclast differentiation via Toll-like receptor 4

Chang, E., Kim, H. J., Ha, J., Kim, H. J., Ryu, J., Park, K., Kim, H., Lee, Z. H., Kim, H., Fisher, D. E., et al. (2006) · Journal of Cell Science · doi:10.1242/jcs.03310 · Cited by 108

Evidence for the Presence of Toll-Like Receptor 4 System in the Human Endometrium

Hirata, T., Osuga, Y., Hirota, Y., Koga, K., Yoshino, O., Harada, M., Morimoto, C., Yano, T., Nishii, O., Tsutsumi, O., et al. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0241 · Cited by 108

Glycyrrhizin and isoliquiritigenin suppress the LPS sensor Toll-like receptor 4/MD-2 complex signaling in a different manner

Honda, H., Nagai, Y., Matsunaga, T., Saitoh, S.-I., Akashi‐Takamura, S., Hayashi, H., Fujii, I., Miyake, K., Muraguchi, A., & Takatsu, K. (2012) · Journal of Leukocyte Biology · doi:10.1189/jlb.0112038 · Cited by 109

Glial scar and immune cell involvement in tissue remodeling and repair following acute CNS injuries

Rapôso, C., & Schwartz, M. (2014) · Glia · doi:10.1002/glia.22676 · Cited by 112

High, but not low, molecular weight hyaluronan prevents T-cell-mediated liver injury by reducing proinflammatory cytokines in mice

Nakamura, K., Yokohama, S., Yoneda, M., Okamoto, S., Tamaki, Y., Ito, T., Okada, M., Aso, K., & Makino, I. (2004) · Journal of Gastroenterology · doi:10.1007/s00535-003-1301-x · Cited by 107

Making and breaking tolerance

Ohashi, P. S., & DeFranco, A. L. (2002) · Current Opinion in Immunology · doi:10.1016/s0952-7915(02)00406-5 · Cited by 107

Type I interferons might form the link between Toll-like receptor (TLR) 3/7 and TLR4-mediated synovial inflammation in rheumatoid arthritis (RA)

Roelofs, M. F., Wenink, M. H., Brentano, F., Abdollahi‐Roodsaz, S., Oppers‐Walgreen, B., Barrera, P., van Riel, P. L. C. M., Joosten, L. A. B., Kyburz, D., van den Berg, W. B., et al. (2008) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2007.086421 · Cited by 110

Haplotype variation in bovine Toll-like receptor 4 and computational prediction of a positively selected ligand-binding domain

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Hyaluronan-CD44-ERK1/2 Regulate Human Aortic Smooth Muscle Cell Motility during Aging

Vigetti, D., Viola, M., Karousou, E., Rizzi, M., Moretto, P., Genasetti, A., Clerici, M., Hascall, V., Luca, G. D., & Passi, A. G. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m709051200 · Cited by 107

NEUTROPHIL ELASTASE, MIP-2, AND TLR-4 EXPRESSION DURING HUMAN AND EXPERIMENTAL SEPSIS

Tsujimoto, H., Ono, S., Majima, T., Kawarabayashi, N., Takayama, E., Kinoshita, M., Seki, S., Hiraide, H., Moldawer, L. L., & Mochizuki, H. (2004) · Shock · doi:10.1097/01.shk.0000145936.31967.d7 · Cited by 107

Review: Pathogen-associated molecular pattern contamination as putative endogenous ligands of Toll-like receptors

Tsan, M., & Gao, B. (2007) · Journal of Endotoxin Research · doi:10.1177/0968051907078604 · Cited by 111

Therapeutic Targeting of Hyaluronan in the Tumor Stroma

Kultti, A. H., Li, X., Jiang, P., Thompson, C. B., Frost, G. I., & Shepard, H. M. (2012) · Cancers · doi:10.3390/cancers4030873 · Cited by 107

Immune cells and non-immune cells with immune function in mammalian cochleae

Hu, B., Zhang, C., & Frye, M. D. (2017) · Hearing Research · doi:10.1016/j.heares.2017.12.009 · Cited by 104

Immunogenicity Challenges Associated with Subcutaneous Delivery of Therapeutic Proteins

Jarvi, N. L., & Balu‐Iyer, S. V. (2021) · BioDrugs · doi:10.1007/s40259-020-00465-4 · Cited by 105

Pattern Recognition Receptor-Dependent Mechanisms of Acute Lung Injury

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Innate immune functions of microglia isolated from human glioma patients

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Mechanisms of Toll-Like Receptor 4 (TLR4)-Mediated Inflammation After Cold Ischemia/Reperfusion in the Heart

Kaczorowski, D. J., Nakao, A., Vallabhaneni, R., Mollen, K. P., Sugimoto, R., Kohmoto, J., Zuckerbraun, B. S., McCurry, K. R., & Billiar, T. R. (2009) · Transplantation · doi:10.1097/tp.0b013e3181a36e5e · Cited by 106

Conditional signaling by Toll‐like receptor 4

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Dissecting the role of hyaluronan synthases in the tumor microenvironment

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Role of hyaluronan and hyaluronan-binding proteins in human asthma

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Intrinsic immunogenicity of rapidly-degradable polymers evolves during degradation

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Expression and Function of Toll-Like Receptors at the Maternal—Fetal Interface

Koga, K., & Mor, G. (2008) · Reproductive Sciences · doi:10.1177/1933719108316391 · Cited by 103

Endotoxin-induced chemokine expression in murine peritoneal mesothelial cells: the role of toll-like receptor 4.

Kato, S., Yuzawa, Y., Tsuboi, N., Maruyama, S., Morita, Y., Matsuguchi, T., & Matsuo, S. (2004) · PubMed · Cited by 103

Inhibition of pattern recognition receptor-mediated inflammation by bioactive phytochemicals

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Toll-like receptors: promising therapeutic targets for inflammatory diseases

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Hyaluronic acid-based extracellular matrix triggers spontaneous M2-like polarity of monocyte/macrophage

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The Role of an IL-10/Hyaluronan Axis in Dermal Wound Healing

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