The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Lipid Raft Microdomains
Open accessAbstract
Spatiotemporal aspects of filovirus entry and release are poorly understood. Lipid rafts act as functional platforms for multiple cellular signaling and trafficking processes. Here, we report the compartmentalization of Ebola and Marburg viral proteins within lipid rafts during viral assembly and budding. Filoviruses released from infected cells incorporated raft-associated molecules, suggesting that viral exit occurs at the rafts. Ectopic expression of Ebola matrix protein and glycoprotein supported raft-dependent release of filamentous, virus-like particles (VLPs), strikingly similar to live virus as revealed by electron microscopy. Our findings also revealed that the entry of filoviruses requires functional rafts, identifying rafts as the site of virus attack. The identification of rafts as the gateway for the entry and exit of filoviruses and raft-dependent generation of VLPs have important implications for development of therapeutics and vaccination strategies against infections with Ebola and Marburg viruses.
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Citations
Cites
Functional rafts in cell membranes
Simons, K., & Ikonen, E. (1997) · Nature · doi:10.1038/42408 · Cited by 9,757
Essential Role for Cholesterol in Entry of Mycobacteria into Macrophages
Gatfield, J., & Pieters, J. (2000) · Science · doi:10.1126/science.288.5471.1647 · Cited by 615
Vesicular Release of Ebola Virus Matrix Protein VP40
Timmins, J., Scianimanico, S., Schoehn, G., & Weissenhorn, W. (2001) · Virology · doi:10.1006/viro.2001.0860 · Cited by 190
A requirement for lipid rafts in B cell receptor induced Ca(2+) flux
Aman, M. J., & Ravichandran, K. S. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00415-2 · Cited by 127
Self-citation
Cited by
Regulated transport of the glucose transporter GLUT4
Bryant, N. J., Govers, R., & James, D. E. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm782 · Cited by 1,183
Virus Entry, Assembly, Budding, and Membrane Rafts
Chazal, N., & Gerlier, D. (2003) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.67.2.226-237.2003 · Cited by 482
Warfield, K. L., Swenson, D. L., Olinger, G. G., Kalina, W. V., Aman, M. J., & Bavari, S. (2007) · The Journal of Infectious Diseases · doi:10.1086/520583 · Cited by 260
Self-citationRole for Human Immunodeficiency Virus Type 1 Membrane Cholesterol in Viral Internalization
Guyader, M., Kiyokawa, E., Abrami, L., Turelli, P., & Trono, D. (2002) · Journal of Virology · doi:10.1128/jvi.76.20.10356-10364.2002 · Cited by 170
Structural basis for membrane attack complex inhibition by CD59
Couves, E. C., Gardner, S., Voisin, T. B., Bickel, J. K., Stansfeld, P. J., Tate, E. W., & Bubeck, D. (2023) · Nature Communications · doi:10.1038/s41467-023-36441-z · Cited by 85
Metadata
- Authors
- Bavari, S., Bosio, C. M., Wiegand, E., Ruthel, G., Will, A. B., Geisbert, T. W., Hevey, M., Schmaljohn, C., Schmaljohn, A., & Aman, M. J.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2002-03-04
- Volume
- 195
- Issue
- 5
- Pages
- 593-602
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2102537321
- Cited by
- 432
- References
- 4
- FWCI
- 27.00
- Type
- journal article
- Language
- en
- Open access
- green
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- Bavari, S., Bosio, C. M., Wiegand, E., Ruthel, G., Will, A. B., Geisbert, T. W., Hevey, M., Schmaljohn, C., Schmaljohn, A., & Aman, M. J. (2002). Lipid Raft Microdomains. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.20011500
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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