The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
HLA-E–dependent Presentation of Mtb-derived Antigen to Human CD8+ T Cells
Open accessAbstract
Previous studies in mice and humans have suggested an important role for CD8+ T cells in host defense to Mtb. Recently, we have described human, Mtb-specific CD8+ cells that are neither HLA-A, B, or C nor group 1 CD1 restricted, and have found that these cells comprise the dominant CD8+ T cell response in latently infected individuals. In this report, three independent methods are used to demonstrate the ability of these cells to recognize Mtb-derived antigen in the context of the monomorphic HLA-E molecule. This is the first demonstration of the ability of HLA-E to present pathogen-derived antigen. Further definition of the HLA-E specific response may aid development of an effective vaccine against tuberculosis.
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Cites
Measurement of protein using bicinchoninic acid
Smith, P. K., Krohn, R. I., Hermanson, G. T., Mallia, A. K., Gartner, F. H., Provenzano, M. D., Fujimoto, E. K., Goeke, N. M., Olson, B. J., & Klenk, D. C. (1985) · Analytical Biochemistry · doi:10.1016/0003-2697(85)90442-7 · Cited by 18,482
Lewinsohn, D. M., Alderson, M. R., Briden, A. L., Riddell, S. R., Reed, S. G., & Grabstein, K. H. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.10.1633 · Cited by 165
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Cited by
Human Mucosal Associated Invariant T Cells Detect Bacterially Infected Cells
Gold, M. C., Cerri, S., Smyk-Pearson, S., Cansler, M. E., Vogt, T. M., Delepine, J., Winata, E., Swarbrick, G. M., Chua, W.-J., Yu, Y. Y. L., et al. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000407 · Cited by 673
Self-citationThe immunological life cycle of tuberculosis
Ernst, J. D. (2012) · Nature Reviews Immunology · doi:10.1038/nri3259 · Cited by 577
Drain, P. K., Bajema, K. L., Dowdy, D., Dheda, K., Naidoo, K., Schumacher, S. G., Ma, S., Meermeier, E., Lewinsohn, D. M., & Sherman, D. R. (2018) · Clinical Microbiology Reviews · doi:10.1128/cmr.00021-18 · Cited by 565
Self-citationTuberculosis Pathogenesis and Immunity
Philips, J. A., & Ernst, J. D. (2012) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-011811-132458 · Cited by 416
Harriff, M. J., Karamooz, E., Burr, A., Grant, W. F., Canfield, E. T., Sorensen, M. L., Moita, L. F., & Lewinsohn, D. M. (2016) · PLOS Pathogens · doi:10.1371/journal.ppat.1005524 · Cited by 87
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Metadata
- Authors
- Heinzel, A. S., Grotzke, J. E., Lines, R. A., Lewinsohn, D. A., McNabb, A. L., Streblow, D. N., Braud, V. M., Grieser, H. J., Belisle, J. T., & Lewinsohn, D. M.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2002-11-25
- Volume
- 196
- Issue
- 11
- Pages
- 1473-1481
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2079808029
- Cited by
- 212
- References
- 2
- FWCI
- 6.75
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Heinzel, A. S., Grotzke, J. E., Lines, R. A., Lewinsohn, D. A., McNabb, A. L., Streblow, D. N., Braud, V. M., Grieser, H. J., Belisle, J. T., & Lewinsohn, D. M. (2002). HLA-E–dependent Presentation of Mtb-derived Antigen to Human CD8+ T Cells. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.20020609
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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