The DOI matches its Crossref record; 46 of the 49 references it cites were found in a registry or an index.
A Point Mutation of Tyr-759 in Interleukin 6 Family Cytokine Receptor Subunit gp130 Causes Autoimmune Arthritis
Open accessAbstract
We generated a mouse line in which the src homology 2 domain–bearing protein tyrosine phosphatase (SHP)-2 binding site of gp130, tyrosine 759, was mutated to phenylalanine (gp130F759/F759). The gp130F759/F759 mice developed rheumatoid arthritis (RA)-like joint disease. The disease was accompanied by autoantibody production and accumulated memory/activated T cells and myeloid cells. Before the disease onset, the T cells were hyperresponsive and thymic selection and peripheral clonal deletion were impaired. The inhibitory effect of IL-6 on Fas ligand expression during activation-induced cell death (AICD) was augmented in gp130F759/F759 T cells in a manner dependent on the tyrosine residues of gp130 required for signal transducer and activator of transcription 3 activation. Finally, we showed that disease development was dependent on lymphocytes. These results provide evidence that a point mutation of a cytokine receptor has the potential to induce autoimmune disease.
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“On the other hand, the enhancement of IL-6–STAT3 signaling causes IL-17A-dependent autoimmune arthritis in mice (41, 63, 66).”
From IL-6 in inflammation, autoimmunity and cancer (2021) · cites this paper as [63]
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Hirano, T., Yasukawa, K., Harada, H., Taga, T., Watanabe, Y., Matsuda, T., Kashiwamura, S.-I., Nakajima, K., Koyama, K., Iwamatsu, A., et al. (1986) · Nature · doi:10.1038/324073a0 · Cited by 2,139 · cited 1×
“IL-6, which was originally identified as a B cell differentiation factor (13, 14), is now known to be a multifunctional cytokine that regulates the immune response, hematopoiesis, the acute phase response, and inflammation (4, 15).”
BackgroundSelf-citationVan Snick, J. (1990) · Annual Review of Immunology · doi:10.1146/annurev.iy.08.040190.001345 · Cited by 1,890 · cited 1×
“IL-6, which was originally identified as a B cell differentiation factor (13, 14), is now known to be a multifunctional cytokine that regulates the immune response, hematopoiesis, the acute phase response, and inflammation (4, 15).”
BackgroundTolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes
Kisielow, P., Blüthmann, H., Staerz, U., Steinmetz, M., & von Boehmer, H. (1988) · Nature · doi:10.1038/333742a0 · Cited by 1,793 · cited 1×
“We crossed gp130F759/F759 mice with anti–HY-TCR transgenic mice to examine the effect of the gp130F759/F759 mutation on thymic selection (39).”
MethodTransgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis.
Keffer, J., Probert, L., Cazlaris, H., Georgopoulos, S., Kaslaris, E., Kioussis, D., & Kollias, G. (1991) · EMBO Journal · doi:10.1002/j.1460-2075.1991.tb04978.x · Cited by 1,675 · cited 1×
“TNF- transgenic mice and TNF AU-rich elements-deficient mice revealed that TNF- is a pivotal cytokine for the induction of other proinflammatory cytokines and for the abnormal growth of synovial cells (9, 10).”
BackgroundImpaired On/Off Regulation of TNF Biosynthesis in Mice Lacking TNF AU-Rich Elements
Kontoyiannis, D. L., Pasparakis, M., Pizarro, T. T., Cominelli, F., & Kollias, G. A. (1999) · Immunity · doi:10.1016/s1074-7613(00)80038-2 · Cited by 1,329 · cited 2×
“This is in sharp contrast to the arthritis that develops in TNF AUrich elements-deficient mice, which is independent of lymphocytes (9).”
BackgroundResultHirano, T., Ishihara, K., & Hibi, M. (2000) · Oncogene · doi:10.1038/sj.onc.1203551 · Cited by 1,207
Self-citationHomeostasis and Self-Tolerance in the Immune System: Turning Lymphocytes off
Parijs, L. V., & Abbas, A. K. (1998) · Science · doi:10.1126/science.280.5361.243 · Cited by 958
Organ-specific disease provoked by systemic autoimmunity.
Kouskoff, V., Korganow, A., Duchatelle, V., Degott, C., Benoist, C., & Mathis, D. (1996) · Cell · doi:10.1016/s0092-8674(00)81989-3 · Cited by 949 · cited 1×
“Analyses of the K/BxN TCR transgenic mouse showed that an autoantibody specific to a ubiquitous molecule can induce an organ-specific autoimmune disease (2, 6, 7).”
BackgroundInterleukin 6 and its receptor: ten years later
Hirano, T. (1998) · International Reviews of Immunology · doi:10.3109/08830189809042997 · Cited by 788
Self-citationExcessive production of interleukin 6/B cell stimulatory factor-2 in rheumatoid arthritis
Hirano, T., Matsuda, T., Turner, M., Miyasaka, N., Buchan, G., Tang, B., Sato, K., Shimi, M., Maid, R., Feldmann, M., et al. (1988) · European Journal of Immunology · doi:10.1002/eji.1830181122 · Cited by 784 · cited 1×
“Since then, several pieces of evidence have been reported that suggest the involvement of IL-6 in autoimmune diseases, including RA (4, 17).”
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van den Berg, W. B. (2011) · Elsevier eBooks · doi:10.1016/b978-0-323-06551-1.00087-7 · Cited by 2
Metadata
- Authors
- Atsumi, T., Ishihara, K., Kamimura, D., Ikushima, H., Ohtani, T., Hirota, S., Kobayashi, H., Park, S.-J., Saeki, Y., Kitamura, Y., & Hirano, T.
- Affiliations
- RIKEN (JP)
- The University of Osaka (JP)
- 1Department of Molecular Oncology (C7), Graduate School of Medicine
- 2Department of Pathology (C2), Graduate School of Medicine
- Kowa (Japan) (JP)
- 3Department of Molecular Medicine (C4), Graduate School of Medicine
- ORCID
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2002-09-30
- Volume
- 196
- Issue
- 7
- Pages
- 979-990
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- PMC
- PMC2194024
- OpenAlex
- W2145478309
- Cited by
- 225
- References
- 49
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 4 · 2023: 4 · 2022: 4 · 2021: 4 · 2020: 3 · 2019: 13 · 2018: 7 · 2017: 7 · 2016: 4 · 2015: 12 · 2014: 10 · 2013: 11 · 2012: 13
- FWCI
- 6.53
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- cc-by-nc-sa
- Locations
- The Journal of Experimental Medicine (publishedVersion)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- gp130, rheumatoid arthritis, autoimmune arthritis, autoantibodies, thymic selection, Fas ligand, activation-induced cell death, STAT3 signaling
- MeSH terms
- Animals, Antibody Formation, Arthritis, Experimental, Base Sequence, Binding Sites, Bone and Bones, Enterotoxins, Lymph Nodes, Mice, Inbred C57BL, Mice, Transgenic, Staphylococcus aureus, T-Lymphocytes, Tyrosine, CD4-Positive T-Lymphocytes, Polymerase Chain Reaction, Apoptosis, Point Mutation, DNA Primers, Superantigens, Amino Acid Substitution, Receptors, Interleukin-6, Protein Subunits, Mice
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