The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Two Roads Diverged: Interferon α/β– and Interleukin 12–mediated Pathways in Promoting T Cell Interferon γ Responses during Viral Infection
Open accessAbstract
Viral infections induce CD8 T cell expansion and interferon (IFN)-γ production for defense, but the innate cytokines shaping these responses have not been identified. Although interleukin (IL)-12 has the potential to contribute, IL-12–dependent T cell IFN-γ has not been detected during viral infections. Moreover, certain viruses fail to induce IL-12, and elicit high levels of IFN-α/β to negatively regulate it. The endogenous factors promoting virus-induced T cell IFN-γ production were defined in studies evaluating CD8 T cell responses during lymphocytic choriomeningitis virus infections of mice. Two divergent supporting pathways were characterized. Under normal conditions of infections, the CD8 T cell IFN-γ response was dependent on endogenous IFN-α/β effects, but was IL-12 independent. In contrast, in the absence of IFN-α/β functions, an IL-12 response was revealed and substituted an alternative pathway to IFN-γ. IFN-α/β–mediated effects resulted in enhanced, but the alternative pathway also promoted, resistance to infection. These observations define uniquely important IFN-α/β–controlled pathways shaping T cell responses during viral infections, and demonstrate plasticity of immune responses in accessing divergent innate mechanisms to achieve similar ultimate goals.
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Type I interferons in infectious disease
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Expanding roles for CD4+ T cells in immunity to viruses
Swain, S. L., McKinstry, K. K., & Strutt, T. M. (2012) · Nature Reviews Immunology · doi:10.1038/nri3152 · Cited by 956
Natural Interferon α/β–Producing Cells Link Innate and Adaptive Immunity
Kadowaki, N., Antonenko, S., Lau, J. Y.-N., & Liu, Y.-J. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.2.219 · Cited by 849
Metadata
- Authors
- Cousens, L. P., Peterson, R., Hsu, S., Dorner, A., Altman, J. D., Ahmed, R., & Biron, C. A.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 1999-04-19
- Volume
- 189
- Issue
- 8
- Pages
- 1315-1328
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W1994310347
- Cited by
- 290
- References
- 52
- FWCI
- 9.29
- Type
- journal article
- Language
- en
- Open access
- green
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- Cousens, L. P., Peterson, R., Hsu, S., Dorner, A., Altman, J. D., Ahmed, R., & Biron, C. A. (1999). Two Roads Diverged: Interferon α/β– and Interleukin 12–mediated Pathways in Promoting T Cell Interferon γ Responses during Viral Infection. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.189.8.1315
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