The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
A role for IgG immune complexes during infection with the intracellular pathogen Leishmania
Open accessAbstract
We examined the role of immunoglobulin (Ig)G antibodies in mediating host defense to the intracellular parasite, Leishmania. We show that IgG not only fails to provide protection against this intracellular pathogen, but it actually contributes to disease progression. The JH strain of BALB/c mice, which lack IgG because they have a targeted deletion in the Ig heavy chain (J) locus, were more resistant to infection with Leishmania major than were normal BALB/c mice. However, the passive administration of anti-Leishmania IgG caused JH mice to develop large lesions containing high numbers of parasites. Antibody administration correlated with an increase in interleukin (IL) 10 production in lesions, and blocking the murine IL-10 receptor prevented antibody-mediated disease exacerbation. In human patients with active visceral leishmaniasis, high IgG levels are predictive of disease. Patients with ongoing disease had high IgG antibody titers and no delayed-type hypersensitivity (DTH) responses to Leishmania antigens. This pattern was reversed upon disease resolution after treatment, resulting in a decrease in total IgG, which was accompanied by a progressive increase in DTH responsiveness. We conclude that IgG can cause a novel form of immune enhancement due to its ability to induce IL-10 production from macrophages.
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Cites
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Cited by
Exploring the full spectrum of macrophage activation
Mosser, D. M., & Edwards, J. P. (2008) · Nature Reviews Immunology · doi:10.1038/nri2448 · Cited by 9,144
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Biochemical and functional characterization of three activated macrophage populations
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Self-citationRegulatory T cells and infection: a dangerous necessity
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The function of Fcγ receptors in dendritic cells and macrophages
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Metadata
- Authors
- Miles, S. A., Conrad, S. M., Alves, R. G., Jeronimo, S. M. B., & Mosser, D. M.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2005-03-07
- Volume
- 201
- Issue
- 5
- Pages
- 747-754
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2115569719
- Cited by
- 263
- References
- 29
- FWCI
- 22.32
- Type
- journal article
- Language
- en
- Open access
- green
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