The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Osteopontin is a hematopoietic stem cell niche component that negatively regulates stem cell pool size
Open accessAbstract
Stem cells reside in a specialized niche that regulates their abundance and fate. Components of the niche have generally been defined in terms of cells and signaling pathways. We define a role for a matrix glycoprotein, osteopontin (OPN), as a constraining factor on hematopoietic stem cells within the bone marrow microenvironment. Osteoblasts that participate in the niche produce varying amounts of OPN in response to stimulation. Using studies that combine OPN-deficient mice and exogenous OPN, we demonstrate that OPN modifies primitive hematopoietic cell number and function in a stem cell–nonautonomous manner. The OPN-null microenvironment was sufficient to increase the number of stem cells associated with increased stromal Jagged1 and Angiopoietin-1 expression and reduced primitive hematopoietic cell apoptosis. The activation of the stem cell microenvironment with parathyroid hormone induced a superphysiologic increase in stem cells in the absence of OPN. Therefore, OPN is a negative regulatory element of the stem cell niche that limits the size of the stem cell pool and may provide a mechanism for restricting excess stem cell expansion under conditions of niche stimulation.
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Citations
Cites
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“For example, granulomatous responses are associated with high levels of OPN expression (16, 17, 20) and OPN can function as a Th1 cell cytokine, enhancing IL-12 while inhibiting expression of the Th2 cell cytokine IL-10 (17, 19, 21).”
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Metadata
- Authors
- Stier, S., Ko, Y., Forkert, R., Lutz, C., Neuhaus, T., Grünewald, E., Cheng, T., Dombkowski, D., Calvi, L. M., Rittling, S. R., & Scadden, D. T.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2005-05-31
- Volume
- 201
- Issue
- 11
- Pages
- 1781-1791
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2120372000
- Cited by
- 714
- References
- 3
- FWCI
- 23.38
- Type
- journal article
- Language
- en
- Open access
- green
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