The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Live imaging of effector cell trafficking and autoantigen recognition within the unfolding autoimmune encephalomyelitis lesion
Open accessAbstract
We tracked pathogenic myelin basic protein-specific CD4+ effector T cells in early central nervous system (CNS) lesions of experimental autoimmune encephalomyelitis (EAE) by combining two-photon imaging and fluorescence video microscopy. We made two key observations: (a) the majority of the cells (65%) moved fast (maximal speed 25 μm/min) and apparently nondirected through the compact tissue; and (b) a second group of effector T cells (35%) appeared tethered to a fixed point. Polarization of T cell receptor and adhesion molecules (lymphocyte function-associated antigen 1) towards this fixed point suggests the formation of immune synapses. Nonpathogenic, ovalbumin-specific T cells were not tethered in the CNS and did not form synapse-like contacts, but moved through the tissue. After intrathecal injection of antigen, 40% of ovalbumin-specific T cells became tethered. Conversely, injection of anti–major histocompatibility complex class II antibodies profoundly reduced the number of stationary pathogenic T cells within the CNS (to 15%). We propose that rapid penetration of the CNS parenchyma by numerous autoimmune effector T cells along with multiple autoantigen-presentation events are responsible for the fulminate development of clinical EAE.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Activated T cells can enter the perivascular space independent of antigen specificity, but are unable to traverse the astrocytic basement membrane and glia limitans.
“Activated T cells can enter the perivascular space independent of antigen specificity (82), but are unable to traverse the astrocytic basement membrane and glia limitans.”
From The anatomy and immunology of vasculature in the central nervous system (2019) · cites this paper as [82]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The Immunological Synapse: A Molecular Machine Controlling T Cell Activation
Grakoui, A., Bromley, S. K., Sumen, C., Davis, M. M., Shaw, A. S., Allen, P. M., & Dustin, M. L. (1999) · Science · doi:10.1126/science.285.5425.221 · Cited by 3,110
Three-dimensional segregation of supramolecular activation clusters in T cells
Monks, C. R. F., Freiberg, B. A., Kupfer, H., Sciaky, N., & Kupfer, A. (1998) · Nature · doi:10.1038/25764 · Cited by 2,353
T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases
Mempel, T. R., Henrickson, S. E., & von Andrian, U. H. (2004) · Nature · doi:10.1038/nature02238 · Cited by 1,720
T‐lymphocyte entry into the central nervous system
Hickey, W. F., Hsu, B. L., & Kimura, H. (1991) · Journal of Neuroscience Research · doi:10.1002/jnr.490280213 · Cited by 1,176
Bromley, S. K., Burack, R., Johnson, K. G., Somersalo, K., Sims, T. N., Sumen, C., Davis, M. M., Shaw, A. S., Allen, P. M., & Dustin, M. L. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.375 · Cited by 979
Ben‐Nun, A., Wekerle, H., & Cohen, I. R. (1981) · European Journal of Immunology · doi:10.1002/eji.1830110307 · Cited by 917
Self-citationReal-Time Single-Molecule Imaging of the Infection Pathway of an Adeno-Associated Virus
Seisenberger, G., Ried, M. U., Endreß, T., Büning, H., Hallek, M. J., & Bräuchle, C. (2001) · Science · doi:10.1126/science.1064103 · Cited by 819
Cellular immune reactivity within the CNS
Wekerle, H., Linington, C., Lassmann, H., & Meyermann, R. (1986) · Trends in Neurosciences · doi:10.1016/0166-2236(86)90077-9 · Cited by 767
Self-citationThe Nonobese Diabetic Mouse as a Model of Autoimmune Diabetes: Immune Dysregulation Gets the NOD
Delovitch, T. L., & Singh, B. (1997) · Immunity · doi:10.1016/s1074-7613(00)80392-1 · Cited by 676
Autonomous T cell trafficking examined in vivo with intravital two-photon microscopy
Miller, M. J., Wei, S. H., Cahalan, M. D., & Parker, I. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2628040100 · Cited by 503
Miller, M. J., Hejazi, A. S., Wei, S. H., Cahalan, M. D., & Parker, I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0306407101 · Cited by 436
Flügel, A., Berkowicz, T., Ritter, T., Labeur, M. S., Jenne, D. E., Li, Z., Ellwart, J. W., Willem, M., Lassmann, H., & Wekerle, H. (2001) · Immunity · doi:10.1016/s1074-7613(01)00143-1 · Cited by 431
Self-citationSumen, C., Mempel, T. R., Mazo, I. B., & von Andrian, U. H. (2004) · Immunity · doi:10.1016/j.immuni.2004.08.006 · Cited by 303
Schmied, M. C., Breitschopf, H., Gold, R., Zischler, H., Rothe, G., Wekerle, H., & Lassmann, H. (1993) · PubMed Central · Cited by 301
Self-citationWekerle, H., Kojima, K., Lannes-Vieira, J., Lassmann, H., & Linington, C. (1994) · Annals of Neurology · doi:10.1002/ana.410360714 · Cited by 291
Self-citationApoptosis in the nervous system in experimental allergic encephalomyelitis
Pender, M. P., Nguyen, K. B., McCombe, P., & Kerr, J. F. R. (1991) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(91)90219-w · Cited by 230
Steinman, L. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.6.2253 · Cited by 222
Kawakami, N., Laßmann, S., Li, Z., Odoardi, F., Ritter, T., Ziemssen, T., Klinkert, W. E. F., Ellwart, J. W., Bradl, M., Krivacic, K. A., et al. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20031064 · Cited by 189
Self-citationFlügel, A., Willem, M., Berkowicz, T., & Wekerle, H. (1999) · Nature Medicine · doi:10.1038/10567 · Cited by 156
Self-citationT-Cell Apoptosis in Inflammatory Brain Lesions
Bauer, J., Bradl, M., Hickey, W. F., Forss‐Petter, S., Breitschopf, H., Linington, C., Wekerle, H., & Lassmann, H. (1998) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65615-5 · Cited by 146
Self-citationMolecular anatomy of antigen-specific CD8+ T cell engagement and synapse formation in vivo
McGavern, D. B., Christen, U., & Oldstone, M. B. A. (2002) · Nature Immunology · doi:10.1038/ni843 · Cited by 124
EYLAR, E. H., Kniskern, P. J., & Jackson, J. J. (1974) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(74)32034-4 · Cited by 111
Tabi, Z., McCombe, P., & Pender, M. P. (1995) · International Immunology · doi:10.1093/intimm/7.6.967 · Cited by 65
Freeing the Brain from the Perineuronal Net
Fox, K. D., & Caterson, B. (2002) · Science · doi:10.1126/science.1079224 · Cited by 57
Activated non-neural specific T cells open the blood–brain barrier to circulating antibodies
Westland, K. W., Pollard, J. D., Sander, S., Bonner, J. G., Linington, C., & McLeod, J. G. (1999) · Brain · doi:10.1093/brain/122.7.1283 · Cited by 50
Flagged first, then by citations
Research works printed but not linked: 3
- 2004, Immunity., 21, 315
- 1993, Am. J. Pathol., 143, 446
- 1979, Methods Enzymol., 32B, 323
Cited by
Sorted by citations
From Monocytes to M1/M2 Macrophages: Phenotypical vs. Functional Differentiation
Italiani, P., & Boraschi, D. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00514 · Cited by 2,067
The movers and shapers in immune privilege of the CNS
Engelhardt, B., Vajkoczy, P., & Weller, R. O. (2017) · Nature Immunology · doi:10.1038/ni.3666 · Cited by 893
Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions.
Bartholomäus, I., Kawakami, N., Odoardi, F., Schläger, C., Miljkovic, D., Ellwart, J. W., Klinkert, W. E. F., Flügel-Koch, C., Issekutz, T. B., Wekerle, H., et al. (2009) · Nature · doi:10.1038/nature08478 · Cited by 685
Self-citationRevisiting the Mechanisms of CNS Immune Privilege
Louveau, A., Harris, T. H., & Kipnis, J. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.08.006 · Cited by 682
The functional network of ion channels in T lymphocytes
Cahalan, M. D., & Chandy, K. G. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2009.00816.x · Cited by 603
Interstitial leukocyte migration and immune function
Friedl, P., & Weigelin, B. (2008) · Nature Immunology · doi:10.1038/ni.f.212 · Cited by 606
Agrawal, S., Anderson, P., Durbeej, M., van Rooijen, N., Ivars, F., Opdenakker, G., & Sorokin, L. M. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20051342 · Cited by 559
Trafficking of immune cells in the central nervous system
Wilson, E. H., Weninger, W., & Hunter, C. A. (2010) · Journal of Clinical Investigation · doi:10.1172/jci41911 · Cited by 547
Multiple sclerosis: experimental models and reality
Lassmann, H., & Bradl, M. (2017) · Acta Neuropathologica · doi:10.1007/s00401-016-1631-4 · Cited by 525
T cells become licensed in the lung to enter the central nervous system
Odoardi, F., Sie, C., Streyl, K., Ulaganathan, V. K., Schläger, C., Lodygin, D., Heckelsmiller, K., Nietfeld, W., Ellwart, J. W., Klinkert, W. E. F., et al. (2012) · Nature · doi:10.1038/nature11337 · Cited by 453
Self-citationThe SIRP family of receptors and immune regulation
Barclay, A. N., & Brown, M. H. (2006) · Nature reviews. Immunology · doi:10.1038/nri1859 · Cited by 427
T cell migration, search strategies and mechanisms
Krummel, M. F., Bartumeus, F., & Gérard, A. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2015.16 · Cited by 423
In vivo imaging of cytotoxic T cell infiltration and elimination of a solid tumor
Boissonnas, A., Fetler, L., Zeelenberg, I. S., Hugues, S., & Amigorena, S. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20061890 · Cited by 378
A Decade of Imaging Cellular Motility and Interaction Dynamics in the Immune System
Germain, R. N., Robey, E. A., & Cahalan, M. D. (2012) · Science · doi:10.1126/science.1221063 · Cited by 370
Effector T-cell trafficking between the leptomeninges and the cerebrospinal fluid
Schläger, C., Körner, H., Krueger, M., Vidoli, S., Haberl, M., Mielke, D., Brylla, E., Issekutz, T., Cabañas, C., Nelson, P. J., et al. (2016) · Nature · doi:10.1038/nature16939 · Cited by 372
Self-citationVascular, glial, and lymphatic immune gateways of the central nervous system
Engelhardt, B., Carare, R. O., Bechmann, I., Flügel, A., Laman, J. D., & Weller, R. O. (2016) · Acta Neuropathologica · doi:10.1007/s00401-016-1606-5 · Cited by 362
Macrophage and T Cell Dynamics during the Development and Disintegration of Mycobacterial Granulomas
Egen, J. G., Rothfuchs, A. G., Feng, C. G., Winter, N., Sher, A., & Germain, R. N. (2008) · Immunity · doi:10.1016/j.immuni.2007.12.010 · Cited by 351
The anatomy and immunology of vasculature in the central nervous system
Mastorakos, P., & McGavern, D. (2019) · Science Immunology · doi:10.1126/sciimmunol.aav0492 · Cited by 333
Siffrin, V., Radbruch, H., Glumm, R., Niesner, R., Paterka, M., Herz, J., Leuenberger, T., Lehmann, S. M., Luenstedt, S., Rinnenthal, J. L., et al. (2010) · Immunity · doi:10.1016/j.immuni.2010.08.018 · Cited by 325
Two-photon fluorescence excitation and related techniques in biological microscopy
Diaspro, A., Chirico, G. G., & Collini, M. (2005) · Quarterly Reviews of Biophysics · doi:10.1017/s0033583505004129 · Cited by 318
Marchetti, L., & Engelhardt, B. (2020) · Vascular Biology · doi:10.1530/vb-19-0033 · Cited by 304
Cahalan, M. D., & Parker, I. (2008) · Annual Review of Immunology · doi:10.1146/annurev.immunol.24.021605.090620 · Cited by 303
Macrophage reaction against biomaterials in the mouse model–phenotypes, functions and markers
Klopfleisch, R. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2016.07.003 · Cited by 298
Kivisäkk, P., Imitola, J., Rasmussen, S. O., Elyaman, W., Zhu, B., Ransohoff, R. M., & Khoury, S. J. (2008) · Annals of Neurology · doi:10.1002/ana.21379 · Cited by 298
Dynamic imaging of the immune system: progress, pitfalls and promise
Germain, R. N., Miller, M. J., Dustin, M. L., & Nussenzweig, M. C. (2006) · Nature reviews. Immunology · doi:10.1038/nri1884 · Cited by 275
Wu, C., Ivars, F., Anderson, P. O., Hallmann, R., Vestweber, D., Nilsson, P., Robenek, H., Tryggvason, K., Song, J., Korpos, É., et al. (2009) · Nature Medicine · doi:10.1038/nm.1957 · Cited by 264
Immunopathogenesis and immunotherapy of multiple sclerosis
Hemmer, B., Nessler, S., Zhou, D., Kieseier, B. C., & Hartung, H. (2006) · Nature Clinical Practice Neurology · doi:10.1038/ncpneuro0154 · Cited by 259
Brain borders at the central stage of neuroimmunology
Rustenhoven, J., & Kipnis, J. (2022) · Nature · doi:10.1038/s41586-022-05474-7 · Cited by 253
Dynamic T cell–APC interactions sustain chronic inflammation in atherosclerosis
Koltsova, E. K., Garcia, Z., Chodaczek, G., Landau, M., McArdle, S., Scott, S. R., von Vietinghoff, S., Galkina, E., Miller, Y. I., Acton, S. T., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci61758 · Cited by 252
Oligoclonal CD8 + T Cells Play a Critical Role in the Development of Hypertension
Trott, D. W., Thabet, S., Kirabo, A., Saleh, M. A., Itani, H. A., Norlander, A. E., Wu, J., Goldstein, A. E., Arendshorst, W. J., Madhur, M. S., et al. (2014) · Hypertension · doi:10.1161/hypertensionaha.114.04147 · Cited by 253
Honda, T., Egen, J. G., Lämmermann, T., Kastenmüller, W., Torabi‐Parizi, P., & Germain, R. N. (2014) · Immunity · doi:10.1016/j.immuni.2013.11.017 · Cited by 239
Random migration precedes stable target cell interactions of tumor-infiltrating T cells
Mrass, P., Takano, H., Ng, L. G., Daxini, S. D., Lasaro, M. O., Iparraguirre, A., Cavanagh, L. L., von Andrian, U. H., Ertl, H. C. J., Haydon, P. G., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20060710 · Cited by 228
Egen, J. G., Rothfuchs, A. G., Feng, C. G., Horwitz, M. A., Sher, A., & Germain, R. N. (2011) · Immunity · doi:10.1016/j.immuni.2011.03.022 · Cited by 220
Leukocyte migration in the interstitial space of non-lymphoid organs
Weninger, W., Biro, M., & Jain, R. (2014) · Nature reviews. Immunology · doi:10.1038/nri3641 · Cited by 226
In vivo imaging of the diseased nervous system
Misgeld, T., & Kerschensteiner, M. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1905 · Cited by 198
Mechanisms and implications of adaptive immune responses after traumatic spinal cord injury
Ankeny, D. P., & Popovich, P. G. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.07.001 · Cited by 197
Matheu, M. P., Beeton, C., Garcia, A., Chi, V., Rangaraju, S., Safrina, O., Monaghan, K. P., Uemura, M. I., Li, D., Pal, S., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.07.015 · Cited by 196
Wilson, E. H., Harris, T. H., Mrass, P., John, B., Wojno, E. D. T., Wu, G. F., Pepper, M., Wherry, E. J., Dzierzinski, F., Roos, D. S., et al. (2009) · Immunity · doi:10.1016/j.immuni.2008.12.013 · Cited by 167
When encephalitogenic T cells collaborate with microglia in multiple sclerosis
Dong, Y., & Yong, V. W. (2019) · Nature Reviews Neurology · doi:10.1038/s41582-019-0253-6 · Cited by 166
Current Evidence for a Role of the Kynurenine Pathway of Tryptophan Metabolism in Multiple Sclerosis
Lovelace, M. D., Varney, B., Sundaram, G., Franco, N. F., Ng, M. L., Pai, S., Lim, C. K., Guillemin, G. J., & Brew, B. J. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00246 · Cited by 161
Perivascular spaces and their role in neuroinflammation
Ineichen, B. V., Okar, S. V., Proulx, S. T., Engelhardt, B., Lassmann, H., & Reich, D. S. (2022) · Neuron · doi:10.1016/j.neuron.2022.10.024 · Cited by 151
Animal models of multiple sclerosis: From rodents to zebrafish
Burrows, D. J., McGown, A., Jain, S. A., De Felice, M., Ramesh, T. M., Sharrack, B., & Majid, A. (2019) · Multiple Sclerosis Journal · doi:10.1177/1352458518805246 · Cited by 135
Pathophysiology of multiple sclerosis
Korn, T. (2008) · Journal of Neurology · doi:10.1007/s00415-008-6001-2 · Cited by 137
Calderón, B., Suri, A., Miller, M. J., & Unanue, E. R. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801973105 · Cited by 133
Davalos, D., Lee, J. K., Smith, W. B., Brinkman, B. C., Ellisman, M. H., Zheng, B., & Akassoglou, K. (2007) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2007.11.011 · Cited by 134
Han, S., Lin, Y. C., Wu, T., Salgado, A. D., Mexhitaj, I., Wuest, S. C., Romm, E., Ohayon, J. M., Goldbach‐Mansky, R. T., Vanderver, A. L., et al. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1302884 · Cited by 125
EAE: An immunologist's magic eye
Krishnamoorthy, G., & Wekerle, H. (2009) · European Journal of Immunology · doi:10.1002/eji.200939568 · Cited by 120
Self-citationSchaeffer, M., Han, S., Chtanova, T., van Dooren, G. G., Herzmark, P., Chen, Y., Roysam, B., Striepen, B., & Robey, E. A. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0804307 · Cited by 118
Multiple sclerosis: a battle between destruction and repair
McQualter, J., & Bernard, C. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04232.x · Cited by 120
A dynamic view of the immunological synapse
Dustin, M. L. (2005) · Seminars in Immunology · doi:10.1016/j.smim.2005.09.002 · Cited by 112
Single-cell transcriptomics reveals functionally specialized vascular endothelium in brain
Jeong, H., Diéguez‐Hurtado, R., Arf, H., Song, J., Park, H., Kruse, K., Sorokin, L. M., & Adams, R. H. (2022) · eLife · doi:10.7554/elife.57520 · Cited by 110
Melzer, N., Meuth, S. G., & Wiendl, H. (2009) · The FASEB Journal · doi:10.1096/fj.09-136200 · Cited by 105
Dynamic Imaging of the Effector Immune Response to Listeria Infection In Vivo
Waite, J. C., Leiner, I. M., Lauer, P., Rae, C. S., Barbet, G., Zheng, H., Portnoy, D. A., Pamer, E. G., & Dustin, M. L. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1001326 · Cited by 103
Barcia, C., Thomas, C. E., Curtin, J. F., King, G. D., Wawrowsky, K., Candolfi, M., Xiong, W.-D., Liu, C., Kroeger, K. M., Boyer, O., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20060420 · Cited by 102
Cellular and molecular events in the localization of diabetogenic T cells to islets of Langerhans
Calderón, B., Carrero, J. A., Miller, M. J., & Unanue, E. R. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1018973108 · Cited by 95
Doi, Y., Oki, S., Ozawa, T., Hohjoh, H., Miyake, S., & Yamamura, T. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803454105 · Cited by 91
Dorand, R. D., Barkauskas, D. S., Evans, T. A., Petrošiūtė, A., & Huang, A. Y.-C. (2014) · IntraVital · doi:10.4161/intv.29728 · Cited by 86
Germain, R. N., Bajénoff, M., Castellino, F., Chieppa, M., Egen, J. G., Huang, A. Y.-C., Ishii, M., Koo, L. Y., & Qi, H. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00591.x · Cited by 87
Glucocorticoids in the control of neuroinflammation
Tischner, D., & Reichardt, H. M. (2007) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2007.03.007 · Cited by 85
Immune cell migration as a means to control immune privilege: lessons from the CNS and tumors
Mrass, P., & Weninger, W. (2006) · Immunological Reviews · doi:10.1111/j.1600-065x.2006.00433.x · Cited by 87
Imitola, J., Rasmussen, S., Liu, Y., Chitnis, T., Khoury, S., Côté, D. C., Xie, X. S., Lin, C. P., & Sidman, R. L. (2011) · Journal of Biomedical Optics · doi:10.1117/1.3533312 · Cited by 79
Common Peripheral Immunity Mechanisms in Multiple Sclerosis and Alzheimer's Disease
Rossi, B., Santos-Lima, B., Terrabuio, E., Zenaro, E., & Constantin, G. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.639369 · Cited by 82
Calderón, B., Carrero, J. A., Miller, M. J., & Unanue, E. R. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1018975108 · Cited by 80
Collateral Bystander Damage by Myelin-Directed CD8+ T Cells Causes Axonal Loss
Sobottka, B., Harrer, M. D., Ziegler, U., Fischer, K., Wiendl, H., Hünig, T., Becher, B., & Goebels, N. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.090340 · Cited by 75
Role of the extracellular matrix in lymphocyte migration
Korpos, É., Wu, C., Song, J., Hallmann, R., & Sorokin, L. M. (2009) · Cell and Tissue Research · doi:10.1007/s00441-009-0853-3 · Cited by 75
The second touch hypothesis: T cell activation, homing and polarization
Ley, K. F. (2014) · F1000Research · doi:10.12688/f1000research.3-37.v2 · Cited by 76
Kim, J. V., Jiang, N., Tadokoro, C. E., Liu, L., Ransohoff, R. M., Lafaille, J. J., & Dustin, M. L. (2009) · Journal of Immunological Methods · doi:10.1016/j.jim.2009.09.007 · Cited by 72
Deane, J. A., & Hickey, M. J. (2009) · Expert Reviews in Molecular Medicine · doi:10.1017/s146239940900115x · Cited by 72
Yu, Z., Xue, F., Liu, W., Sun, R. X., Zhou, J., Pu, Y., Zhao, M., Sun, D., Xiang, Z., Liu, P., et al. (2022) · Advanced Science · doi:10.1002/advs.202105442 · Cited by 70
Unoda, K., Doi, Y., Nakajima, H., Yamane, K., Hosokawa, T., Ishida, S., Kimura, F., & Hanafusa, T. (2012) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2012.12.003 · Cited by 70
Copland, D. A., Wertheim, M. S., Armitage, W. J., Nicholson, L. B., Raveney, B. J. E., & Dick, A. D. (2008) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.08-2348 · Cited by 71
Cordiglieri, C., Marolda, R., Franzi, S., Cappelletti, C., Giardina, C., Motta, T., Baggi, F., Bernasconi, P., Mantegazza, R., & Cavalcante, P. (2014) · Journal of Autoimmunity · doi:10.1016/j.jaut.2013.12.013 · Cited by 68
Cordiglieri, C., Odoardi, F., Zhang, B., Nebel, M., Kawakami, N., Klinkert, W. E. F., Lodygin, D., Lühder, F., Breunig, E., Schild, D., et al. (2010) · Brain · doi:10.1093/brain/awq135 · Cited by 68
Self-citationCNS‐irrelevant T‐cells enter the brain, cause blood–brain barrier disruption but no glial pathology
Тихоновна, С. А., Wuerfel, J. T., Pohl, E. E., Vogt, J., Tysiak, E., Glumm, R., Hendrix, S., Nitsch, R., Zipp, F., & Infante‐Duarte, C. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05792.x · Cited by 66
Anti-Selectin Therapy for the Treatment of Inflammatory Diseases
Rossi, B., & Constantin, G. (2008) · Inflammation & Allergy - Drug Targets · doi:10.2174/187152808785107633 · Cited by 66
Clarkson, B. D. S., Walker, A. J., Harris, M. G., Rayasam, A., Sándor, M., & Fábry, Z. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1401320 · Cited by 68
An extended vision for dynamic high-resolution intravital immune imaging
Germain, R. N., Castellino, F., Chieppa, M., Egen, J. G., Huang, A. Y.-C., Koo, L. Y., & Qi, H. (2005) · Seminars in Immunology · doi:10.1016/j.smim.2005.09.003 · Cited by 65
Almolda, B., Costa, M., Montoya, M., González, B., & Castellano, B. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027473 · Cited by 64
Effector CD4+ T cells recognize intravascular antigen presented by patrolling monocytes
Westhorpe, C. L. V., Norman, M. U., Hall, P., Snelgrove, S. L., Finsterbusch, M., Li, A., Lo, C. Y.-W., Tan, Z., Li, S., Nilsson, S. K., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03181-4 · Cited by 66
Kawakami, N., & Flügel, A. (2010) · Seminars in Immunopathology · doi:10.1007/s00281-010-0216-x · Cited by 62
Self-citationOdoardi, F., Kawakami, N., Klinkert, W. E. F., Wekerle, H., & Flügel, A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705033104 · Cited by 61
Self-citationExperimental Autoimmune Encephalomyelitis in the Rat
Swanborg, R. H., & Stepaniak, J. A. (1996) · Current Protocols in Immunology · doi:10.1002/0471142735.im1502s19 · Cited by 60
Siewert, K., Malotka, J., Kawakami, N., Wekerle, H., Hohlfeld, R., & Dornmair, K. (2012) · Nature Medicine · doi:10.1038/nm.2720 · Cited by 60
Self-citationImaging the choreography of lymphocyte trafficking and the immune response
Cahalan, M. D., & Parker, I. (2006) · Current Opinion in Immunology · doi:10.1016/j.coi.2006.05.013 · Cited by 61
Chapter 16 Two‐Photon Microscopy and Multidimensional Analysis of Cell Dynamics
Zinselmeyer, B. H., Dempster, J., Wokosin, D. L., Cannon, J. J., Pless, R. B., Parker, I., & Miller, M. J. (2009) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(09)05416-0 · Cited by 59
Mechanisms for lesion localization in neuromyelitis optica spectrum disorders
Bradl, M., Reindl, M., & Lassmann, H. (2018) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000551 · Cited by 59
Pathophysiology and genetics of salt-sensitive hypertension
Maaliki, D. S., Itani, M. M., & Itani, H. A. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.1001434 · Cited by 61
Interactions Between Microglia and T Cells in Multiple Sclerosis Pathobiology
Strachan-Whaley, M. R., Rivest, S., & Yong, V. W. (2014) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2014.0019 · Cited by 54
Clark, R. T., Nance, J. P., Noor, S., & Wilson, E. H. (2011) · ASN NEURO · doi:10.1042/an20100027 · Cited by 54
Chow, Z., Mueller, S. N., Deane, J. A., & Hickey, M. J. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1203205 · Cited by 54
Jeon, S. G., Yoo, A., Chun, D. W., Hong, S. B., Chung, H., Kim, J.-I., & Moon, M. (2020) · Aging and Disease · doi:10.14336/ad.2019.0718 · Cited by 57
Odoardi, F., Kawakami, N., Li, Z., Cordiglieri, C., Streyl, K., Nosov, M., Klinkert, W. E. F., Ellwart, J. W., Bauer, J., Lassmann, H., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608383104 · Cited by 52
Self-citationA public T cell clonotype within a heterogeneous autoreactive repertoire is dominant in driving EAE
Menezes, J. S., van den Elzen, P., Thornes, J., Huffman, D., Droin, N. M., Maverakis, E., & Sercarz, E. E. (2007) · Journal of Clinical Investigation · doi:10.1172/jci28277 · Cited by 53
Close encounters of the first and second kind: T–DC and T–B interactions in the lymph node
Cahalan, M. D., & Parker, I. (2005) · Seminars in Immunology · doi:10.1016/j.smim.2005.09.001 · Cited by 51
Bajénoff, M., & Germain, R. N. (2007) · European Journal of Immunology · doi:10.1002/eji.200737663 · Cited by 49
Herz, J., Paterka, M., Niesner, R. A., Brandt, A. U., Siffrin, V., Leuenberger, T., Birkenstock, J., Mossakowski, A. A., Glumm, R., Zipp, F., et al. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-131 · Cited by 51
An autoimmunity odyssey: how autoreactive T cells infiltrate into the CNS
Kawakami, N., Bartholomäus, I., Pesic, M., & Mues, M. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01133.x · Cited by 49
Self-citationBreaking Ignorance: The Case of the Brain
Wekerle, H. (2006) · Springer eBooks · doi:10.1007/3-540-29714-6_2 · Cited by 49
Self-citationHeterogeneous T cell motility behaviors emerge from a coupling between speed and turning in vivo
Jerison, E. R., & Quake, S. R. (2020) · eLife · doi:10.7554/elife.53933 · Cited by 48
Metadata
- Authors
- Kawakami, N., Nägerl, U. V., Odoardi, F., Bonhoeffer, T., Wekerle, H., & Flügel, A.
- Affiliations
- Max Planck Institute of Neurobiology (DE)
- 2Department of Cellular and Systems Neurobiology, Max-Planck-Institute of Neurobiology, 82152 Martinsried, Germany
- 1Department of Neuroimmunology, Max-Planck-Institute of Neurobiology, 82152 Martinsried, Germany
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2005-06-06
- Volume
- 201
- Issue
- 11
- Pages
- 1805-1814
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- PMC
- PMC2213265
- OpenAlex
- W2153979851
- Cited by
- 248
- References
- 25
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 6 · 2023: 9 · 2022: 9 · 2021: 7 · 2020: 5 · 2019: 7 · 2018: 7 · 2017: 4 · 2016: 17 · 2015: 3 · 2014: 19 · 2013: 11 · 2012: 12
- FWCI
- 15.92
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- cc-by-nc-sa
- Locations
- The Journal of Experimental Medicine (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- Max Planck Digital Library (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (SFB455)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- experimental autoimmune encephalomyelitis, myelin basic protein, CD4+ T cells, autoantigen recognition, immunological synapse, CD11a/CD18, ovalbumin-specific T cells, MHC class II, autoantigen presentation, two-photon imaging
- MeSH terms
- Animals, Histocompatibility Antigens Class II, Autoantigens, Cell Communication, Cell Movement, Central Nervous System, Myelin Basic Protein, Encephalomyelitis, Autoimmune, Experimental, Guinea Pigs, Rats, Inbred Lew, Receptors, Antigen, T-Cell, CD4-Positive T-Lymphocytes, Lymphocyte Function-Associated Antigen-1, Antigen Presentation, Microscopy, Video, Microscopy, Fluorescence, Multiphoton, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
