The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.
IL-18–induced CD83+CCR7+NK helper cells
Open accessAbstract
In addition to their cytotoxic activities, natural killer (NK) cells can have immunoregulatory functions. We describe a distinct “helper” differentiation pathway of human CD56+CD3− NK cells into CD56+/CD83+/CCR7+/CD25+ cells that display high migratory responsiveness to lymph node (LN)–associated chemokines, high ability to produce interferon-γ upon exposure to dendritic cell (DC)- or T helper (Th) cell–related signals, and pronounced abilities to promote interleukin (IL)-12p70 production in DCs and the development of Th1 responses. This helper pathway of NK cell differentiation, which is not associated with any enhancement of cytolytic activity, is induced by IL-18, but not other NK cell–activating factors. It is blocked by prostaglandin (PG)E2, a factor that induces a similar CD83+/CCR7+/CD25+ LN-homing phenotype in maturing DCs. The current data demonstrate independent regulation of the “helper” versus “effector” pathways of NK cell differentiation and novel mechanisms of immunoregulation by IL-18 and PGE2.
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Sallusto, F., & Lanzavecchia, A. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.179.4.1109 · Cited by 5,129
Interleukin-12 and the regulation of innate resistance and adaptive immunity
Trinchieri, G. (2003) · Nature Reviews Immunology · doi:10.1038/nri1001 · Cited by 3,927
Cloning of a new cytokine that induces IFN-γ production by T cells
Okamura, H., Tsutsui, H., Komatsu, T., Yutsudo, M., Hakura, A., Tanimoto, T., Torigoe, K., Okura, T., Nukada, Y., Hattori, K., et al. (1995) · Nature · doi:10.1038/378088a0 · Cited by 2,600
Human natural killer cells: a unique innate immunoregulatory role for the CD56bright subset
Cooper, M. A., Fehniger, T. A., Turner, S. C., Chen, K. S., Ghaheri, B. A., Ghayur, T., Carson, W. E., & Caligiuri, M. A. (2001) · Blood · doi:10.1182/blood.v97.10.3146 · Cited by 1,449
Induced recruitment of NK cells to lymph nodes provides IFN-γ for TH1 priming
Martín-Fontecha, A., Thomsen, L. L., Brett, S., Gerard, C., Lipp, M., Lanzavecchia, A., & Sallusto, F. (2004) · Nature Immunology · doi:10.1038/ni1138 · Cited by 1,353
Lymphokine Production by Human T Cells in Disease States
Romagnani, S. (1994) · Annual Review of Immunology · doi:10.1146/annurev.immunol.12.1.227 · Cited by 1,343
Severe Herpesvirus Infections in an Adolescent without Natural Killer Cells
Biron, C. A., Byron, K. S., & Sullivan, J. L. (1989) · New England Journal of Medicine · doi:10.1056/nejm198906293202605 · Cited by 1,269
Lymphocyte traffic control by chemokines
Moser, B., & Loetscher, P. (2001) · Nature Immunology · doi:10.1038/84219 · Cited by 1,240
The Role of Chemokine Receptors in Primary, Effector, and Memory Immune Responses
Sallusto, F., Mackay, C. R., & Lanzavecchia, A. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.593 · Cited by 1,041
Reciprocal Activating Interaction between Natural Killer Cells and Dendritic Cells
Gerosa, F., Baldani-Guerra, B., Nisii, C., Marchesini, V., Carra, G., & Trinchieri, G. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20010938 · Cited by 1,028
Cited by
The interleukin-1 family: back to the future
Garlanda, C., Dinarello, C. A., & Mantovani, A. (2013) · Immunity · doi:10.1016/j.immuni.2013.11.010 · Cited by 1,945
“IL-18 is a keymediator in the interaction between NK cells and DC or macrophages (e.g., Bellora et al., 2012; Mailliard et al., 2005).”
A rapid and robust method for single cell chromatin accessibility profiling
Chen, X., Miragaia, R. J., Natarajan, K. N., & Teichmann, S. A. (2018) · Nature Communications · doi:10.1038/s41467-018-07771-0 · Cited by 1,147
The trafficking of natural killer cells
Grégoire, C., Chasson, L., Luci, C., Tomasello, E., Geissmann, F., Vivier, E., & Walzer, T. (2007) · Immunological Reviews · doi:10.1111/j.1600-065x.2007.00563.x · Cited by 569
Romagnani, C., Juelke, K., Falco, M., Morandi, B., D’Agostino, A., Costa, R., Ratto, G., Forte, G., Carrega, P., Lui, G., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.8.4947 · Cited by 494
Developmental pathways that generate natural-killer-cell diversity in mice and humans
Huntington, N. D., Vosshenrich, C. A. J., & Di Santo, J. P. (2007) · Nature Reviews Immunology · doi:10.1038/nri2154 · Cited by 461
Metadata
- Authors
- Mailliard, R. B., Alber, S. M., Shen, H., Watkins, S. C., Kirkwood, J. M., Herberman, R. B., & Kalinski, P.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2005-10-03
- Volume
- 202
- Issue
- 7
- Pages
- 941-953
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2133790771
- Cited by
- 286
- References
- 59
- FWCI
- 4.72
- Type
- journal article
- Language
- en
- Open access
- green
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